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PubMed · 6128452

Wearable artificial endocrine pancrease with needle-type glucose sensor.

M Shichiri·R Kawamori·Y Yamasaki·N Hakui·H Abe
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Abstract

Miniaturisation of the bedside artificial endocrine pancreas in necessary to provide a means of restoring physiological glycaemic excursions in diabetic patients in the long term. One of the remaining problems in producing such a sophisticated device is the difficulty in developing a sufficiently small glucose-monitoring system. A needle-type glucose sensor has been developed which is suitable for use in a closed-loop glycaemic control system. The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs: the device produced perfect control of blood glucose for up to 7 days.

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AnimalsBlood GlucoseDogsElectrodesGlucagonGlucoseHypoglycemiaInsulin Infusion SystemsMicrocomputersNeedlesJournal ArticleResearch Support, Non-U.S. Gov't

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M Shichiri, R Kawamori, Y Yamasaki, N Hakui, H Abe. 1982-11-20. Wearable artificial endocrine pancrease with needle-type glucose sensor.. https://doi.org/10.1016/s0140-6736(82)92788-x

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