Probability screening model.

N V Dmitrieva; S V Nizhnii; L A Piruzyan; E S Polishchuk

PubMed · 549679

Probability screening model.

N V Dmitrieva·S V Nizhnii·L A Piruzyan·E S Polishchuk

Abstract

A comparative analysis is given of various types of systems of selecting biologically active substances. A theoretical probability model of tests on chemical compounds for biological activity (screening) has been constructed which permits an evaluation of the efficacy of screening on the basis of fairly reasonable assumptions. It has been shown that this efficacy decreases in time with a fixed number of types of activity taken into consideration and rises sharply with an increase in the number of types of activity of chemical compounds taken into account in the tests.

Explore related subjects

Drug Evaluation, Preclinical Mathematics Models, Theoretical Probability Comparative Study Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

N V Dmitrieva, S V Nizhnii, L A Piruzyan, E S Polishchuk. Probability screening model.. https://pubmed.ncbi.nlm.nih.gov/549679/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Lack of activity of zidovudine against Ureaplasma urealyticum and Mycoplasma hominis.

Explore the source record for details and available documents.

Drug Evaluation, Preclinical↗

PubMed1992

Useful functions of microbial metabolites.

The mood-enhancing effects of fungi and their medicinal properties have been recognized for centuries. Ergot was initially used by midwives to speed childbirth in the Middle Ages. More recently their pharmacological action on dopamine receptors has been exploited to treat post-partum bleeding, migraine, Parkinson's disease and senile dementia. Further indications of the potential value of microbial metabolites are exemplified by the discovery and development of cyclosporin, to treat organ rejection, and mevinolin, a cholesterol-lowering drug. Such discoveries are not unexpected because we have known for some time that fungi regulate morphogenesis, differentiation and sexuality via hormonal molecules, ranging from peptides through to steroidal molecules similar in structure to human sex hormones. A combination of the power of molecular biology to design screens based on isolated disease mechanisms with the chemical inventiveness of microorganisms is providing numerous new pharmacophores for drug development.

Drug Evaluation, Preclinical↗

PubMed1992

Flexibilized gelatin film-based artificial skin model: I. Preparation and properties of the films.

A method was developed to prepare a simple, flexibilized gelatin film-based artificial skin model. The films are tough, adhere to open wounds spontaneously, are permeable to body fluids, and can release incorporated bioactive compounds over 4-5 days.

Drug Evaluation, Preclinical↗