Biomedical subjects
Publications and source records attributed to E S Polishchuk.
Lung ventilation and central hemodynamics in the course of treatment of 43 patients with pulmonary tuberculosis were studied. Registered ventilation and hemodynamic disturbances disappeared with an effectively conducted chemotherapy.
Computerized devices were used for evaluation of the state of pulmonary ventilation and central hemodynamics in 32 patients with pulmonary tuberculosis depending on the spread of the specific process. Patients with limited changes in the lungs, showed disorders of bronchial patency and compensatory increase of organic ejection of the right ventricle. In the presence of spread changes in the lungs the above mentioned changes were supplemented by restrictive ventilation disorders with a reduction of the contractile myocardial capacity. These functional changes should be considered in the treatment of patients with pulmonary tuberculosis.
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As a result of a study of 262 patients with chronic destructive tuberculosis of the lungs the authors revealed that these patients showed personality disorders that impede adequate treatment. Psychotherapy carried out in 5.2% of patients aimed at correction of personality disorders enabled to increase treatment efficacy of chronic destructive pulmonary tuberculosis.
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A comparative analysis is given of various types of systems of selecting biologically active substances. A theoretical probability model of tests on chemical compounds for biological activity (screening) has been constructed which permits an evaluation of the efficacy of screening on the basis of fairly reasonable assumptions. It has been shown that this efficacy decreases in time with a fixed number of types of activity taken into consideration and rises sharply with an increase in the number of types of activity of chemical compounds taken into account in the tests.