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PubMed · 2800645

[Studies with temocillin].

S Crusius
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Abstract

This is a report about microbiological investigations with a new Penicillin-derivate. Temocillin is the first beta-lactamase stable Penicillin with an excellent bactericidal effect against almost all clinically important gram-negative aerobic germs. The antibacterial activity of Temocillin was determined against 355 multiresistent Enterobacteriaceae-strains. We ascertained minimal bacteriostatic and the minimal bactericidal concentration with help of macrodilution-test. The ratio of resistant strains amounted to 0.8%. In vitro investigations with the combination Temocillin and Gentamicin (checker-board-technique) showed 91% indifference and 9% addition, respectively, in 35 Enterobacteriaceae-strains, investigated. Resistances against Temocillin and Ampicillin were cultured through subinhibitory concentrations to predict parallel resistances possible.

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BacteriuriaDose-Response Relationship, DrugEnterobacteriaceaeEnterobacteriaceae InfectionsHumansMicrobial Sensitivity TestsPenicillinsPyelonephritisEnglish AbstractJournal Article

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S Crusius. 1989. [Studies with temocillin].. https://pubmed.ncbi.nlm.nih.gov/2800645/

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