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PubMed · 16618656

Do topical nasal decongestants affect polyps?

Leif Johansson·Dan Oberg·Ingemar Melén·Mats Bende
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Abstract

CONCLUSIONS: The hypothesis that decongestants reduce the size of nasal polyps could not be verified. Decongestion is therefore recommended prior to nasal endoscopy, especially in polyp diagnosis, as it does not artificially change the size of the polyps. OBJECTIVE: The role of nasal decongestants in nasal stuffiness is well established and their action is well known. Decongestants are also used prior to nasal endoscopy to achieve a better view of the nasal cavity in order to diagnose polyps. The question is whether this decongestion invalidates the estimation of polyp size in clinical and scientific practice. The aim of this study was to evaluate possible effects of topical decongestants on polyp extension in patients with nasal polyposis. MATERIAL AND METHODS: The effect of the decongestants nafazoline and epinephrine on nasal polyp size was assessed by means of a double-blind, placebo-controlled randomized study. A sensitive endoscopic scoring system, lateral imaging, was used to assess the size and extension of the nasal polyps. RESULTS: No significant effect of decongestion on polyp size could be found for either treatment.

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Administration, IntranasalAdultAgedAnalysis of VarianceDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleEndoscopyEpinephrineFemaleFollow-Up StudiesHumansMaleMiddle AgedNaphazolineNasal DecongestantsNasal PolypsProbabilityRisk AssessmentTreatment OutcomeComparative StudyJournal ArticleRandomized Controlled Trial

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Leif Johansson, Dan Oberg, Ingemar Melén, Mats Bende. 2006. Do topical nasal decongestants affect polyps?. https://doi.org/10.1080/00016480500388877

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