PubMed · 14231223
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T KAERN. 1964. [ECLAMPSIA].. https://pubmed.ncbi.nlm.nih.gov/14231223/
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BACKGROUNDIncreasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (iSDSE) have been detected worldwide.AIMWe aimed to investigate iSDSE infection incidence rates in Denmark during 2014-2024, and characterise the genomic population structure of a subset of iSDSE isolates and their antimicrobial resistance (AMR).METHODSUsing national register data, we estimated overall and sex-/age-stratified iSDSE incidences during 2014-2024, by retrospectively identifying cases of invasive infections with group C and G streptococci or S. dysgalactiae (including specified as subspecies equisimilis). From the voluntary national beta-haemolytic streptococci laboratory surveillance system, whole-genome-sequenced isolates from August 2020-September 2022 were used to investigate the iSDSE genomic population structure. Susceptibility to penicillin, erythromycin and clindamycin was determined and AMR genes identified.RESULTSDuring 2014-2024, iSDSE incidence rates increased significantly (linear trend analysis p < 0.001) with mean annual incidence ranging between 10.3 and 16.4 per 100,000, peaking in 2023. Incidence was higher in males, increasing with older age. Nearly 75% of the 1,223 iSDSE isolates belonged to four of 14 genetic clusters. Sequence types (STs) ST20 and ST17 were most prevalent, while emm-type stG62647, a variant associated internationally with higher virulence, dominated. All isolates were phenotypically susceptible to penicillin but approximately 10% were respectively erythromycin and clindamycin resistant. High erythromycin resistance prevalence (57%; 39/68), coinciding with gene ermA, occurred in one genetic cluster.CONCLUSIONThe findings illustrate the need for national registry-based surveillance to detect epidemiological changes and potential outbreaks. Further, continuous genomic surveillance can monitor the occurrence and expansion of genetic clades and AMR genes.
Arne Torkildsen (1899-1968) developed Torkildsen's operation, the first successful shunt operation treating increased intraventricular pressure in the brain. He defended his doctoral thesis "Ventriculo-cisternostomy" in the University of Copenhagen in 1950, a thesis that had been rejected by the University of Oslo in his home country Norway. He was not found qualified for the post of associate professor in neurosurgery in spite of being recommended by two international adjudicating committees on four occasions. Torkildsen was accused of having misled the university by omitting one third of the operated patients from his thesis. No-one actually called him a cheat, but tales of cheating and infighting between colleagues aspiring to the same academic posts leave a confusing picture. This paper sums up the story and the possible motives different actors might have had for trying to promote or stop Torkildsen's academic career.
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