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At least 19 recordsLinked to original sources
PubMed1991

Recruitment of pathology trainees. Recent trends from the 1989 Association of Pathology Chairmen's Survey of first-year pathology residents.

The evolving pathology manpower shortage requires that we examine recruitment issues closely. We present data from the 1989 Association of Pathology Chairmen residents' questionnaire and analyze the most important recruitment patterns. Of 685 first-year pathology residents in 1989, 451 (66%) responded to the survey. When compared with other specialties, 1989 pathology residents are older (mean age, 30.1 years), more frequently women (38%), more often foreign medical graduates (23%), and more commonly have MD/PhD degrees (7.8%). Among pathology residents, the fifth year of required training is the most important negative factor in choosing pathology. Over 50% of 1989 first-year pathology residents changed their mind about another specialty to enter pathology; 37% chose pathology only after graduating from medical school. In 1988 and 1989, 63% of first-year pathology residents responding to the Association of Pathology Chairmen residents' questionnaire indicated that role models were an important factor in their specialty choice. The most typical role model was a male pathologist, approximately 47 to 48 years old. Role model influence tended to be greater for those residents who decided to enter pathology earlier in medical school. Nevertheless, over 50% of those residents who decided to enter pathology after medical school claimed that role model influence was important in their choice. Role models remain a valuable resource for improved recruitment into pathology.

Adult↗
PubMed1995

Organized quantitative pathology. Short review of the activities of the Committee for Diagnostic Quantitative Pathology from 1981 to the foundation of the International Society of Diagnostic Quantitative Pathology in 1994.

The Committee for Diagnostic Quantitative Pathology (CDQP), known originally as the Committee for Diagnostic Morphometry, ceased to exist under the original title and was converted to the International Society for Diagnostic Quantitative Pathology (ISDQP) in Amsterdam, September 14, 1994. The history of this society started in 1981 in a conference < > held at Koli, Finland. Since the original meeting the group of quantitative pathologists organized yearly gatherings: Symposia on Diagnostic Quantitative Pathology (earlier known as Symposia on Morphometry in Morphological Diagnosis) every other year, and meetings in association with the European Society of Pathology Congresses in the intervening years. In 1981, the symposium had 23 participants, in 1994, the International Society for Diagnostic Quantitative Pathology had over 300 members from six continents. During the short period of its existence the society has witnessed a steadily growing trend in educational courses on quantitative pathology. The general policy of the Committee, now Society, has willingly supported all activities which can be expected to lead to valuable results in quantitative microscopy and associated fields either through development of education, methodology or practical applications. By arranging a course of Diagnostic Quantitative Pathology the society participates in the activities of the European School of Pathology in Torino. The next symposia of the Society will be arranged in Heidelberg, October 1995 and in Sendai, Japan, October/November 1996.

Europe↗
PubMedDate not supplied

Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia.

The present study concerns an autopsied case of dementia with Lewy bodies (DLB) showing advanced Lewy pathology but minimal Alzheimer pathology. The patient was a 50-year-old Japanese male without inheritance. His initial symptoms at the age of 43 suggested the diagnosis ofjuvenile idiopathic Parkinson's disease (PD), but were followed by memory disturbance 1 year later. He showed parkinsonism, dementia, personality change, fluctuating cognition and visual hallucinations 3 years later. Neuroradiological examination revealed moderate brain atrophy, predominantly in the frontal and temporal lobes. Neuropathological examination demonstrated a widespread occurrence of Lewy bodies (LB) with LB-related neurites not only in the brainstem but also in the cerebrum. The present case showed Lewy pathology which corresponded to stage IV by our staging and was parallel to neuronal loss. There was marked neuronal loss with many LB-related neurites in the CA2 of the hippocampus. Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent. Consequently, the present case was pathologically diagnosed as having DLB of the neocortical type, pure form. In the present study, we suggest that Lewy pathology in the cerebral cortex could be responsible for progressive dementia.

Alzheimer Disease↗
PubMed1979

[Considerations on a pathology of the diaphragm. 1st Report: the pathology of the diaphragm as a part of a pathology of respiration (author's transl)].

The first part of this paper deals with the idea of a "pathology of the diaphragm" and its special relations to the respiration on phylogenetical and ontogenetical base. A pathology of diaphragm does not exist until now. The diaphragm represents an important respiration organ in orthological and pathological conditions. The function of this organ is described and derivated from its specific anatomical structure and topographical site. In this conception the pathology of the diaphragm is a part of the complex pathology of the respiration. A systematic presentation of diaphragm diseases will follow in a second part of this paper.

Animals↗
PubMed2002

Radical prostatectomy for pathological Gleason 8 or greater prostate cancer: influence of concomitant pathological variables.

PURPOSE: We evaluated the long-term outcome of radical prostatectomy for pathological Gleason score 8 or greater prostate cancer and characterized the prognostic significance of other pathological variables. MATERIALS AND METHODS: A total of 6,419 patients underwent radical prostatectomy between 1987 and 1996. There were 407 patients classified as having pathological Gleason 8 or greater, including 8 in 48%, 9 in 49% and 10 in 3%. Adjuvant treatment was used in 45% of patients and adjuvant hormonal therapy was administered to 155 (38%). Progression-free, including local or systemic, and/or prostate specific antigen (PSA) 0.4 ng./ml. or greater, and cancer specific survival were determined by the Kaplan-Meier method. The effect of pathological grade and stage, preoperative PSA, DNA ploidy, margin status, tumor dimension, seminal vesicle invasion, and adjuvant treatment was assessed with the univariate and multivariate analyses. RESULTS: Pathological stage distribution was pT2 in 26% of patients, pT3 48% and pTxN+ 27%. Overall and progression-free survival at 10 years was 67% and 36%, respectively, compared to cancer specific survival 85%. Adjuvant treatment, pathological stage, preoperative PSA and pathological grade were significant (less than 0.05) univariate predictors of progression-free survival. Pathological stage, margin status and ploidy were univariately associated with cancer specific survival. Progression-free survival at 10 years of those patients who did and did not receive adjuvant treatment was 52% and 23%, respectively. In the multivariate analysis pathological grade (p=0.02), preoperative PSA (p <0.0001), adjuvant therapy (p <0.0001) and pathological stage (p=0.036) were significant independent predictors of progression-free survival. CONCLUSIONS: High grade prostate cancer can be controlled with radical prostatectomy in some patients with disease confined pathologically, and 10-year cause specific survival is 96%. Predictors of outcome in patients with Gleason 8 disease or greater are similar to established predictors derived by using all grades. Although adjuvant hormonal therapy appears to improve disease progression rates after radical prostatectomy on the basis of this nonrandomized study, it may not affect prostate cancer death rates within 10 years in patients with high grade cancer.

Aged↗
PubMed2000

Pathology data in the central databases of multicenter randomized trials need to be based on pathology reports and controlled by trained quality managers.

PURPOSE: Randomized multicenter trials form the basis of health care development. Regarding cancer research, pathology data are crucial. To maintain the quality of these trials, the auditing of subsequent processes is necessary. The aim of the present study was to examine the completeness and accuracy of data obtained from a special-purpose standardized pathology form compared with the data available through traditional hospital pathology reports. PATIENTS AND METHODS: A retrospective comparison of pathology data case record forms with hospital pathology reports was performed using the data from 300 patients with primary rectal cancer. All of these patients had been included in a large multicenter trial in the Netherlands. Three independent audits were carried out. Special attention was given to the accuracy of parameters, which are important for prognosis and treatment decisions. Furthermore, various factors that possibly influence the occurrence of errors were investigated. RESULTS: Quality control of the pathology data revealed a high accuracy of 86.5% of all data items. However, only one third of the forms were complete and correct. Missing values were most prominent in the number of lymph nodes examined, whereas most errors were made in relation to the circumferential margin. Trained review pathologists made fewer major errors. Discrepancies were detected in all control rounds. CONCLUSION: Successive rounds of quality control are required for accuracy and completeness of pathology data in multicenter trials. In addition to the special-purpose pathology forms, original pathology reports have to be collected, and the data should also be controlled by a trained pathology quality manager.

Databases, Factual↗