Search PubMed⌕ Search

Biomedical subjects

T J David

Publications and source records attributed to T J David.

At least 109 records · Page 6Linked to original sources
PubMed1989

Short stature in children with atopic eczema.

Short stature, defined as a standing height below the third centile when corrected for mid-parental height, was found in 22% of children with atopic eczema troublesome enough to cause regular attendance at hospital. The cause of this short stature is unknown in most cases, but contributory factors comprise topical steroid therapy, co-existing asthma, inhaled or oral steroid therapy, malnutrition due to unsupervised dietary restriction, loss of sleep, and vitamin D deficiency. If the short stature is simply associated with severe disease and not attributable to steroid therapy, and if the disease remits before puberty, then catch-up growth can be expected. If the short stature is caused by steroid therapy, or if severe disease persists into adult life, then permanent growth stunting may occur.

Adrenal Cortex Hormones↗
PubMed1988

Chronic enteric virus infection in two T-cell immunodeficient children.

Enteric virus infections were studied in two children with congenital T-cell immunodeficiency. One patient (LC) with cartilage hair hypoplasia developed persistent diarrhea and malabsorption following acute gastroenteritis. Electron microscope (EM) examination of feces revealed excretion of rotavirus for more than 450 days with concurrent astrovirus infection for at least 225 days, associated with the persistent diarrhea. Prolonged infection with poliovirus type 2 following vaccination had previously been noted in this patient. The second patient (DT), with the CHARGE association and DiGeorge syndrome, had two episodes of loose stools. EM of fecal extracts demonstrated rotavirus excretion for at least 66 days following the initial episode. Virus-specific immune responses were assayed in these two patients. LC showed a poor serum neutralizing antibody response to polio vaccination, no detectable antibody response (by immune EM and ELISA) to rotavirus, and no detectable antibody response to astrovirus (by immune EM). Rotavirus specific cell mediated immunity was also not detectable. DT showed no detectable serum antibody response to rotavirus (by ELISA). Rotavirus isolates from both patients were found to be group A viruses and were further analyzed by polyacrylamide gel electrophoresis. Atypical genome profiles, with multiple additional bands between segments 3-7 of the normal rotavirus profile, were obtained throughout the course of each illness, including the earliest specimens available (day 41, LC; day 7, DT). These results indicate that chronic virus infection of the gut can occur in patients with T-cell immunodeficiency. Such chronic infection may be associated with persistent diarrhea and can cause considerable problems of management.

Antibodies, Viral↗
PubMed1988

One-year prospective cross-sectional study to assess the importance of group F adenovirus infections in children under 2 years admitted to hospital.

A 1-year prospective cross-sectional study of 363 children under 2 years of age admitted to hospital was undertaken to assess the importance of group F adenovirus infections. Faeces obtained within 48 hours of admission from 97 patients with and 266 patients without diarrhoea were screened by electron microscopy. Viruses were identified by morphological criteria, and all adenoviruses seen were retested by immune electron microscopy to identify group F serotypes. Group F adenoviruses (4 infections) were second in frequency to rotaviruses (16 infections), and both viruses were significantly associated with diarrhoea (P = 0.005 and 0.00001 respectively, chi-squared test). All four group F infections occurred in children with diarrhoeal disease aged between 1 and 6 months and were numerically as important as rotavirus (three infections) in this group. Rotavirus infections occurred significantly more frequently in the 7-24-month age group with diarrhoea (11 v.0 infections, P = 0.001, chi-squared test). Nosocomial infection occurred with group F adenovirus as well as rotavirus. The finding that group F adenoviruses occur as frequently as rotaviruses in diarrhoeal disease that results in hospital admission in children between 1 and 6 months of age could have important implications for preventative strategies.

Adenoviridae Infections↗
PubMed1988

Atopic eczema and preterm birth.

In a group of 443 children with atopic eczema there was a significant lack of subjects born before 37 weeks' gestation. It is possible that preterm birth reduces the chances of the subsequent development of severe atopic disease.

Dermatitis, Atopic↗
PubMed1988

Food additives.

Explore the source record for details and available documents.

Child↗
PubMed1987

Reactions to dietary tartrazine.

Double blind challenges with tartrazine and benzoic acid were performed in hospital in 24 children whose parents gave a definite history of a purely behavioural immediate adverse reaction to one of these substances. The patients, whose ages ranged from 1.6 to 12.4 years, were on a diet that avoided these items, and in all there was a clear history that any lapse of the diet caused an obvious adverse behavioural reaction within two hours. In no patient was any change in behaviour noted either by the parents or the nursing staff after the administration of placebo or active substances. Twenty two patients returned to a normal diet without problems, but the parents of two children insisted on continuing the diet. While popular belief has it that additives may have harmful behavioural effects, objective verification is required to prevent overdiagnosis.

Azo Compounds↗
PubMed1987

Serological evidence of herpes simplex virus infection in atopic eczema.

Twenty three of 113 patients (20%) with atopic eczema had neutralising antibodies to herpes simplex virus compared with 34 of 113 matched controls (30%), an insignificant difference. This suggests that children with atopic eczema are no more likely to acquire herpes simplex infection than normal children.

Adolescent↗
PubMed1987

Steroid scare.

Explore the source record for details and available documents.

Administration, Inhalation↗
PubMed1987

Growth impairment in children with atopic eczema.

Growth was studied in 89 children with atopic eczema aged 1-16 years. Nine (10%) had a standing height below the 3rd centile. Both boys and girls had significantly reduced sitting height but normal subischial leg length, and both sexes had significantly delayed skeletal maturity scores. Impaired growth was particularly associated with widespread eczema, but also with the presence of asthma and the potency of topical corticosteroid. Six of the 15 patients with a corrected height centile below the 10th centile had been receiving potent (British National Formulary category I or II) topical corticosteroids. This study suggests that impaired linear growth is a feature of atopic eczema. While the causes of the growth impairment are unclear, there is a need for caution in the use of potent topical corticosteroids in children.

Adolescent↗
PubMed1986

Bacterial infection and atopic eczema.

One hundred and ninety children with atopic eczema were studied prospectively for two and a half years. The mean period of observation was 13 months. Seventy six children (40%) had between them 164 episodes of exacerbation of eczema due to bacterial infection, and in 52 (32%) infection recurred within three months of a previous infection. Twenty five episodes (15%) led to admission to hospital. Staphylococcus aureus was recovered in 97% of episodes, in combination with beta haemolytic streptococci in 62%. Physical signs suggesting infection were pustules, crusting, and a weeping discharge, but these signs alone are not diagnostic, and an exacerbation was only attributed to infection if there was a response to anti-infective treatment. Exacerbation of atopic eczema due to bacterial infection is common, the physical signs of infection are not always clear, and there is a case for a trial of oral antibiotics in any child with troublesome atopic eczema.

Adolescent↗