Search PubMed⌕ Search

Biomedical subjects

T J David

Publications and source records attributed to T J David.

At least 91 records · Page 5Linked to original sources

Atopic and seborrheic dermatitis: practical management.

Atopic dermatitis is common and causes sleep loss, a disfiguring appearance, an unpleasant odour, teasing, short stature and restriction of career choice in severe cases. There are no drugs which control the scratching; distraction, keeping the nails short and smooth, and the use of mittens at night are all helpful. The sedative action of the older H1 antihistamines makes them useful if scratching prevents a child from falling asleep. Emollients are useful for the associated skin dryness. The least potent topical steroids should be used sparingly to avoid the main hazards of skin atrophy, systemic absorption and growth stunting. Bacterial skin infection with Staphylococcus aureus and sometimes beta-haemolytic streptococci is common and is best treated with oral antibiotics. Herpes simplex virus skin infection is also common; the initial infection occasionally causes a lethal (if untreated) illness. Allergy to house dust mites, pet animals, pollen and food can worsen dermatitis in some cases. There is no test however, which can be used to predict those patients who will respond to avoidance measures, so that management tends to be based on empirical trials of antigen avoidance. Seborrheic dermatitis is a common disorder that usually occurs in the first months of infancy. Findings consist of greasy yellow scales on the scalp (most simply treated with an emollient) and well-demarcated erythematous patches in the diaper area that spread to other areas such as the axillae and neck (usually requiring topical steroids). Some cases go on to develop atopic dermatitis, but many others, although florid, resolve spontaneously.

Administration, Cutaneous↗

Childhood food intolerance.

Food intolerance can arise as a result of a variety of mechanisms, and is common in childhood. The diagnosis is confirmed by response to food avoidance and challenge, and treatment is by specific food avoidance, with dietetic supervision to ensure nutritional adequacy of the diet.

Animals↗

Recent developments in the treatment of childhood atopic eczema.

Even with the most careful application of conventional treatment, atopic eczema can be a disabling handicap in severely affected children. In refractory cases the conventional therapeutic options--potent topical steroids or the use of systemic steroids--are potentially hazardous and associated with relapse after therapy has been discontinued. The main drawbacks to recent experimental approaches, such as oral cyclosporin, photochemotherapy or interferon-gamma, are relapse after cessation of therapy and potentially serious side-effects. Avoidance of certain foods, pets and house dust mites is an option, the major drawbacks being the lack of tests to identify triggers or predict response, and the possible nutritional or psychological hazards of elimination diets. Difficulties with these approaches emphasis the need for close attention to the details of conventional treatment.

Administration, Topical↗

Disseminated porokeratosis in an infant with craniosynostosis.

An infant with craniosynostosis and other congenital defects developed a progressive skin rash from the age of 1 month. Histological examination revealed dyskeratosis and a cornoid lamella suggestive of porokeratosis. This patient is remarkable for the early onset and severity of the skin disease.

Abnormalities, Multiple↗

Cartilaginous pseudocyst of the external auricle in children with atopic eczema.

Four children with severe atopic eczema developed painless endochondral pseudocysts of the external auricle. The lesions were bilateral in two cases. In one case the lesion spontaneously resolved; of the remaining five lesions, one contained haematoma and the other four contained serous fluid. The aetiology of these lesions and their association with atopic eczema are unclear, but repeated minor trauma from rubbing may play a part.

Child, Preschool↗

Serum levels of trace metals in children with atopic eczema.

The hypothesis that atopic eczema is associated with a non-specific decrease in the serum concentration of trace metals was examined by measurement of the levels of zinc, copper and iron in 134 children with atopic eczema and 112 controls. The results failed to confirm the hypothesis. There was no significant difference between patients and controls for the concentrations of serum zinc, iron, iron-binding capacity and albumin. Patients with eczema had a significantly higher copper concentration (median 21.0 mumol/l) than controls (median 17.0 mumol/l), and a significantly lower concentration of ferritin (median 11.9 ng/ml for patients and 16.5 ng/ml for controls). There was a highly significant correlation between the surface area of skin affected by eczema and the concentrations of albumin and orosomucoid.

Child↗

Cystic fibrosis.

Explore the source record for details and available documents.

Child↗

Intolerance to oral and intravenous calcium supplements in atopic eczema.

Children treated with dietary restriction for food intolerance may require calcium supplementation, particularly if cows' milk and milk substitutes are not tolerated. We report two children with atopic eczema who reacted adversely to a number of calcium supplement formulations.

Administration, Oral↗

Calcium intake and cows' milk free diets.

In children with atopic eczema on elimination diets, the calcium intake was below the estimated requirement in 15 out of 20 who avoided cows' milk and received no milk substitute, and in three out of 26 who avoided cows' milk but were provided with a soya or casein hydrolysate formula.

Adolescent↗