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PubMed · 8804136

Typical and atypical neuroleptic drugs decrease platelet 3H-dopamine uptake in the rat.

S Sundram·B Dean·D L Copolov
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Abstract

Reports of opposing changes in platelet 3H-dopamine uptake in neuroleptic-free versus neuroleptic-treated schizophrenic subjects have suggested an effect of neuroleptic treatment on this measure. We examined platelet 3H-dopamine uptake in rats treated with haloperidol or clozapine to determine if such treatment did affect platelet 3H-dopamine uptake. Neuroleptic drug treatment reduced platelet 3H-dopamine uptake in a dose- and time-dependent manner. After up to 4 weeks of treatment, these effects were reversed by the discontinuation of neuroleptic drug treatment. These data suggest that the effect of neuroleptic treatment in studies of platelet 3H-dopamine uptake could account for the variable findings in schizophrenia.

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AnimalsAntipsychotic AgentsBlood PlateletsClozapineDopamineDose-Response Relationship, DrugDrug Administration ScheduleHaloperidolMaleRatsRats, Sprague-DawleyComparative StudyJournal Article

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S Sundram, B Dean, D L Copolov. 1996-06-01. Typical and atypical neuroleptic drugs decrease platelet 3H-dopamine uptake in the rat.. https://doi.org/10.1016/0165-1781(96)02855-7

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