[Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?].

D Peillon; J Dubost; C Roche; J Bienvenu; P Breton; P Y Carry; M Freidel; V Banssillon

doi:10.1016/0750-7658(96)85037-4

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[Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?].

D Peillon·J Dubost·C Roche·J Bienvenu·P Breton·P Y Carry·M Freidel·V Banssillon

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Abstract

OBJECTIVE: To assess the efficiency of corticosteroids and preoperative acute normovolaemic haemodilution (PANHD) in reducing postoperative inflammation after maxillofacial surgery. STUDY DESIGN: Randomized clinical trial. PATIENTS: Thirty-two patients scheduled to undergo maxillary osteotomy for facial dysmorphia were randomized into four groups of eight (PANHD or not; corticosteroids or not). METHODS: PANHD decreased haematocrit to 30%. In the corticosteroid groups, methylprednisolone 1.5 mg.kg-1 was given intravenously at the beginning of surgery (after PANHD in haemodiluted group), and after surgery, 1.5 mg.kg-1 iv daily for three days. Postoperative inflammation was assessed with an X-Ray technique (radiotelemetry) providing data on tissue thickness (extent of facial oedema), and by measurement of plasma concentrations of four acute phase proteins during the first postoperative week. RESULTS: No change in facial oedema and in acute phase proteins occurred with PANHD. Corticosteroids decreased postoperative oedema and acute phase proteins. CONCLUSION: Corticosteroids decrease postoperative inflammation after maxillofacial surgery but not PANHD.

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Acute-Phase Proteins Adult Anti-Inflammatory Agents Facial Bones Female Hemodilution Humans Inflammation Male Methylprednisolone Middle Aged Osteotomy Postoperative Complications Skull Clinical Trial Comparative Study English Abstract Journal Article Randomized Controlled Trial

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D Peillon, J Dubost, C Roche, J Bienvenu, P Breton, P Y Carry, M Freidel, V Banssillon. 1996. [Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?].. https://doi.org/10.1016/0750-7658(96)85037-4

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