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PubMed · 4039650

Xorphanol.

J F Howes·J E Villarreal·L S Harris·E M Essigmann·A Cowan
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Abstract

Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.

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AnimalsChemical PhenomenaChemistryHumansMaleMiceMice, Inbred StrainsMorphinansMorphinePainRatsRats, Inbred StrainsSubstance-Related DisordersTime FactorsUrinationJournal Article

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J F Howes, J E Villarreal, L S Harris, E M Essigmann, A Cowan. 1985. Xorphanol.. https://doi.org/10.1016/0376-8716(85)90068-7

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