PubMed · 353283
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U Mittwoch. 1978. Parthenogenesis.. https://doi.org/10.1136/jmg.15.3.165
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The elimination of (14C)-DMN after i.p. injection into Xenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver from Xenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism by Xenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic in Xenopus.
The actions on amphibian embryos of UV-irradiation, exposure to Li+ or exposure to ouabain show interesting parallels with their effects on spontaneous release at the presynaptic terminals of the neuromuscular junction. It is suggested that these treatments serve to raise intracellular Ca2+ ([Ca2+]i) in these examples, and that UV-promoted abnormalities in embryogenesis are a consequence of changes in [Ca2+]i at critical stages in development.
Scanning electron microscopy of the caudal end of the roof of the fourth cerebral ventricle in four amphibian species shows that numerous pores occur between the ependymal cells. These pores have diameters ranging from 5--100 micron; they permit bluk flow of cerebrospinal fluid out of the ventricular system into the subarachnoid space.