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Biomedical subjects

U Mittwoch

Publications and source records attributed to U Mittwoch.

12 recordsLinked to original sources
PubMed1979

Early testicular development in sex reversed mice.

A comparison is made of two sets of data bearing on the development of testes in XX, Sxr mice. Although Spoljar and Drews (1978) reported no significant difference in the growth rates of XX and XY testes, nevertheless their data suggest that such a difference may exist. This confirms earlier work by Mittwoch and Buehr (1973), who found the testicular volumes of XX embryos aged 15 and 16 days to be below those of XY embryos.

Animals↗
PubMed1978

Parthenogenesis.

Explore the source record for details and available documents.

Amphibians↗
PubMed1977

Sex and lateral asymmetry of the finger ridge-count.

In a sample 719 individuals, the bimanual difference in ridge-count (right minus left) differed only slightly between the two sexes, the mean difference being 0-621 (females minus males). This is not statistically significant, but further evidence suggests that this difference may be real.

Dermatoglyphics↗
PubMed1977

Effects of topically potent glucocorticoids on human diploid fibroblasts in vitro.

A wide range of concentrations of both cortisol and a topically more potent synthetic derivative, fluocinolone acetonide, was found not to inhibit the growth of cultured human skin fibroblasts; fluocinolone acetonide produced a slight increase in the growth rate. Both steroids had a transient stimulatory effect on fibroblasts, promoting an earlier entry into the period DNA synthesis (S) which was also accompanied by a substantial increase in the length of S.

Cell Division↗
PubMed1977

H-Y antigen and the growth of the dominant gonad.

The evolutionary conservation of H-Y antigen and its expression in the heterogametic sex regardless of whether this is male or female must mean that the antigen is associated with a common denominator underlying the development of mammalian testes and avian ovaries. It is suggested that one such common denominator is an enhanced growth rate of the dominant heterogametic gonad at a critical stage of its development.

Animals↗
PubMed1976

Differential growth of human foetal gonads with respect to sex and body side.

Measurements have been carried out on the gonads of 54 human foetuses, 29 males and 25 females. Crown-rump lengths ranged between 140 and 212 mm. The criteria used were fresh weight, total protein contents and total DNA contents. It was found that for any given crown-rump length class, the mean values of testes exceeded those of ovaries for all three criteria. It was also found that the mean values of right gonads exceeded those of left gonads. Since in true hermaphrodites, testes are preferentially situated on the right and ovaries on the left side, it is concluded that there is a causal relationship between increased growth rate and testicular differentiation. It is suggested that in normal development this function is performed by the Y chromosome.

Body Height↗
PubMed1975

Changes in the mitotic cycle induced by alpha-solanine.

Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.

Autoradiography↗