Rethinking the microprocessor.

Hervé Seitz; Phillip D Zamore

doi:10.1016/j.cell.2006.05.018

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PubMed · 16751089

Rethinking the microprocessor.

Hervé Seitz·Phillip D Zamore

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Abstract

MicroRNAs (miRNAs) are tiny regulators of gene expression that are processed from longer primary transcripts. In this issue, Han et al. (2006) report some of the structural features of the primary transcript that ensure that the Drosha-DGCR8 enzyme complex liberates precisely the correct precursor sequence, enabling production of a fully functional miRNA.

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Animals Evolution, Molecular Humans MicroRNAs Models, Molecular Nucleotides Proteins RNA Precursors RNA Processing, Post-Transcriptional RNA-Binding Proteins Ribonuclease III Comment Journal Article Review

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Hervé Seitz, Phillip D Zamore. 2006-06-02. Rethinking the microprocessor.. https://doi.org/10.1016/j.cell.2006.05.018

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