Structural basis of multimer-mediated mayhem.

Kajal V Sitwala; Jay L Hess

doi:10.1016/j.ccr.2006.03.022

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Structural basis of multimer-mediated mayhem.

Kajal V Sitwala·Jay L Hess

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Abstract

Oligomerization of AML1-ETO contributes to leukemogenesis through obscure mechanisms. In this issue of Cancer Cell, Bushweller and colleagues show the crystal structure of the ETO NHR2 domain to be a tetramer. Tetramer formation is important for maturation arrest and self-renewal, and gene expression is altered in the absence of self-association. Loss of oligomer formation disrupts interactions between AML1-ETO and members of the ETO corepressor family, but not other corepressor molecules posited to be important for leukemogenesis. The findings clarify the role of oligomer formation in AML1-ETO function and suggest a possible therapeutic strategy of targeting ETO-corepressor interactions.

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Kajal V Sitwala, Jay L Hess. 2006. Structural basis of multimer-mediated mayhem.. https://doi.org/10.1016/j.ccr.2006.03.022

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