Craniofacial bone tissue engineering.

Derrick C Wan; Randall P Nacamuli; Michael T Longaker

doi:10.1016/j.cden.2005.11.003

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Craniofacial bone tissue engineering.

Derrick C Wan·Randall P Nacamuli·Michael T Longaker

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Abstract

Repair and reconstruction of the craniofacial skeleton represents a significant biomedical burden, with thousands of procedures per-formed annually secondary to injuries and congenital malformations. Given the multitude of current approaches, the need for more effective strategies to repair these bone deficits is apparent. This article explores two major modalities for craniofacial bone tissue engineering: distraction osteogenesis and cellular based therapies. Current understanding of the guiding principles for each of these modalities is elaborated on along with the knowledge gained from clinical and investigative studies. By laying this foundation, future directions for craniofacial distraction and cell-based bone engineering have emerged with great promise for the advancement of clinical practice.

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Biomechanical Phenomena Bone Substitutes Bone Transplantation Cell Culture Techniques Cell Transplantation Facial Bones Humans Osseointegration Osteogenesis, Distraction Plastic Surgery Procedures Skull Tissue Engineering Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Derrick C Wan, Randall P Nacamuli, Michael T Longaker. 2006. Craniofacial bone tissue engineering.. https://doi.org/10.1016/j.cden.2005.11.003

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