[Decrease of mutagenic action of cyclophosphamide by buckwheat melanin preparation].

V A Baraboĭ; A D Durnev; A V Oreshchenko; T N Alekseeva; V N Ogarkov; L V Samusenok; V A Pestunovich

PubMed · 16100912

[Decrease of mutagenic action of cyclophosphamide by buckwheat melanin preparation].

V A Baraboĭ·A D Durnev·A V Oreshchenko·T N Alekseeva·V N Ogarkov·L V Samusenok·V A Pestunovich

Abstract

Melanins are polyphenolic pigments of plants, animals and microbes with antioxidant and antiradiation activity. Water-soluble melanin from buckwheat is experienced as antimutagenic means (0.01-10 mg/kg per os) for cyclophosphamide (20 mg/kg i.p.) in the 3 series of experiments. The frequency of chromosome aberrations in the cells of mice bone marrow after mutagene is reduced 2-6 times once under influence of melanin.

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Animals Antimutagenic Agents Bone Marrow Cells Chromosome Aberrations Cyclophosphamide Fagopyrum Male Melanins Mice Mice, Inbred C57BL Mutagens English Abstract Journal Article

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V A Baraboĭ, A D Durnev, A V Oreshchenko, T N Alekseeva, V N Ogarkov, L V Samusenok, V A Pestunovich. [Decrease of mutagenic action of cyclophosphamide by buckwheat melanin preparation].. https://pubmed.ncbi.nlm.nih.gov/16100912/

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