Decoding dopamine signaling.

James A Bibb

doi:10.1016/j.cell.2005.07.011

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Decoding dopamine signaling.

James A Bibb

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Abstract

Dopamine is a key neurotransmitter that is important for many physiological functions including motor control, mood, and the reward pathway. In this issue of Cell, the laboratories of Marc Caron and Li-Huei Tsai identify two very different molecules--beta-arrestin 2 and Par-4, respectively--that unexpectedly are involved in dopamine signaling via the D2 receptor. These two new signaling pathways mediate the actions of dopamine on behavior and facilitate crosstalk between different signaling pathways that are activated by binding of dopamine to the D2 receptor.

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Animals Apoptosis Regulatory Proteins Arrestins Dopamine Intracellular Signaling Peptides and Proteins Mice Mutation Receptors, Dopamine D2 Signal Transduction beta-Arrestin 2 beta-Arrestins Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Comment

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James A Bibb. 2005-07-29. Decoding dopamine signaling.. https://doi.org/10.1016/j.cell.2005.07.011

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