Taking two TRAILS.

Richard M Ransohoff; Bruce D Trapp

doi:10.1016/j.neuron.2005.04.028

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Taking two TRAILS.

Richard M Ransohoff·Bruce D Trapp

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Abstract

The TNF-related apoptosis-inducing ligand (TRAIL) has well-described anti-inflammatory effects in models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). In this issue of Neuron, Aktas, Smorodchenko, and colleagues present evidence that TRAIL exerts anti-inflammatory effects, but also induces neuronal apoptosis, in EAE. This report poses the therapeutic challenge of facilitating TRAIL expression in the periphery while inhibiting TRAIL in the CNS.

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Animals Apoptosis Regulatory Proteins Encephalomyelitis, Autoimmune, Experimental Humans Membrane Glycoproteins Neurons TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha Comment Journal Article Review

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Richard M Ransohoff, Bruce D Trapp. 2005-05-05. Taking two TRAILS.. https://doi.org/10.1016/j.neuron.2005.04.028

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