Nitric oxide-producing polyurethanes.

Ho-Wook Jun; Lakeshia J Taite; Jennifer L West

doi:10.1021/bm049419y

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PubMed · 15762649

Nitric oxide-producing polyurethanes.

Ho-Wook Jun·Lakeshia J Taite·Jennifer L West

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Abstract

Thrombus formation and eventual intimal hyperplasia are the leading causes of small-diameter synthetic vascular graft failure. To combat these issues, we have incorporated a diazeniumdiolate-modified nitric oxide (NO)-producing peptide into a polyurethane to improve the thromboresistance of this biocompatible polymer. NO production by polyurethane films occurred for approximately 2 months under physiological conditions, and mechanical properties of the material were suitable for vascular graft applications. Platelet adhesion to NO-releasing polyurethane was dramatically decreased compared to control polyurethane. Furthermore, endothelial cell growth was stimulated in the presence of the NO-releasing polyurethane, while smooth muscle cell growth was greatly inhibited. The ability of this bioactive material to inhibit platelet adhesion and smooth muscle cell proliferation while encouraging endothelialization suggests that this NO-generating polyurethane may be suitable as a candidate material for small-diameter vascular grafts.

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Animals Aorta Azo Compounds Cattle Cell Proliferation Coated Materials, Biocompatible Endothelium, Vascular Graft Occlusion, Vascular Muscle, Smooth, Vascular Nitric Oxide Nitric Oxide Donors Platelet Adhesiveness Polyurethanes Rats Rats, Sprague-Dawley Thrombosis Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Ho-Wook Jun, Lakeshia J Taite, Jennifer L West. Nitric oxide-producing polyurethanes.. https://doi.org/10.1021/bm049419y

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