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PubMed · 15662372

Evolutionary genomics: detecting selection needs comparative data.

Rasmus Nielsen·Melissa J Hubisz
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Abstract

Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

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AnimalsBiological EvolutionCodonGenomeGenomicsModels, GeneticMutagenesisMutation, MissensePlasmodium falciparumReproducibility of ResultsSelection, GeneticCommentComparative StudyJournal Article

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Rasmus Nielsen, Melissa J Hubisz. 2005-01-20. Evolutionary genomics: detecting selection needs comparative data.. https://doi.org/10.1038/nature03222

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