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PubMed · 1428068

Ascorbic acid status in uremics.

R G Singh·A K Gupta·S S Dubey·Usha·M R Sharma
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Abstract

Plasma levels of ascorbic acid (AA) and dehydroascorbic acid (DHA) were estimated in 27 patients of end stage renal failure (ESRF) on standard conservative therapy (group A) and 9 patients of ESRF on maintenance haemodialysis (MHD; group B). Fourteen healthy subjects matched for age and sex served as control (group C). The dietary intake of vitamin C was significantly decreased in group A than in group B compared to control. Similarly, plasma AA was significantly lowered to 0.801 +/- 0.283 mg per cent in group A compared to 1.421 +/- 0.47 mg per cent in control. While it was just lowered to 1.058 +/- 0.272 mg per cent in group B. Although plasma level of DHA was raised to 0.243 +/- 0.486 mg per cent and 0.166 +/- 0.54 mg per cent in groups A and B respectively, the increase was not statistically significant. In our present study, the DHA/AA ratio was found to be inversely proportional to the plasma AA. Further, this ratio has been claimed to be a better indicator of overall reducing atmosphere (i.e., profile of vitamin C) of the body.

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Ascorbic AcidAscorbic Acid DeficiencyDehydroascorbic AcidEatingFemaleHumansKidney Failure, ChronicMaleMiddle AgedRenal DialysisUremiaComparative StudyJournal Article

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R G Singh, A K Gupta, S S Dubey, Usha, M R Sharma. 1992. Ascorbic acid status in uremics.. https://pubmed.ncbi.nlm.nih.gov/1428068/

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