Search PubMed⌕ Search
Home/Archive/PubMed

PubMed · 1416631

X-linked pathologic myopia.

F M Gregg·E B Feinberg
View original source ↗Export metadata ↓

Abstract

We examined a patient with decreased visual acuity and macular changes attributable to pathologic myopia. Thirteen additional family members were examined, and historic information was obtained on their relatives. A pedigree spanning six generations was constructed that demonstrated an X-linked mode of inheritance. This finding has important genetic and therapeutic implications for similarly affected patients.

Explore related subjects

ChorioretinitisFundus OculiGenetic LinkageHumansMaleMiddle AgedMyopiaPedigreeVisual AcuityX ChromosomeCase ReportsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F M Gregg, E B Feinberg. 1992. X-linked pathologic myopia.. https://pubmed.ncbi.nlm.nih.gov/1416631/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1992

Birdshot retinochoroidopathy in monozygotic twins.

Birdshot retinochoroidopathy is a rare ocular disorder which was named and delineated as a separate clinical entity by Ryan & Maumenee in 1980. We diagnosed birdshot retinochoroidopathy in a monozygotic pair of twins, who were affected with a time interval of 12 years, respectively. These are the first with birdshot retinochoroidopathy to be reported from the Nordic countries and the first report on this disorder in monozygotic twins. Due to night-blindness, visual field defects and a severely affected electroretinogram one of our cases initially was diagnosed as a choroidoretinal dystrophy. Birdshot retinochoroidopathy should be kept in mind as a differential diagnosis in retinitis pigmentosa-like disorders with widespread choroidal involvement. Our cases substantiated the evidence of a strong correlation with the presence of HLA-A29 antigen.

Chorioretinitis↗
PubMed1992

Viral infections of the choroid and retina.

DNA (herpes viruses) and RNA (rubella, rubeola) group viruses are recognized causes of viral retinitis. Severe damage is often the result, not only because the viruses have a cytologic effect but also because the antigens may cause immune complex deposition that results in vasculitis. Most of the viral retinitides are associated with systemic disease; immune-compromised individuals are more susceptible than healthy individuals. A distinct clinical entity, acute retinal necrosis, affects the eye only in healthy individuals and is associated with the herpes family of viruses.

Chorioretinitis↗
PubMed1991

[Determining the level of malondialdehyde in patients with different types of tuberculous uveitis].

A clinical follow-up of 52 tuberculous uveitis patients showed that the choice of an appropriate plan of pathogenetic treatment and prognosis of the disease outcome requires differentiation of types of a tuberculous process in the eye. A new method has been suggested for determining the type of the tuberculous uveitis course by studying changes in the blood content of malonic dialdehyde (increase, decrease or absence of changes).

Chorioretinitis↗