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PubMed · 11624525

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Abstract

The authors are investigated the life and all activity of the man of note since the time of Bulgarian National Renaissance. He graduate Medical Faculty in Bucurest and establish contacts with g.s. Rakovsky, Vasil Levsky and others Bulgarian revolutionary. After his back in Bulgaria he was physician in the town Stara Zagora and Sliven. N. Planinsky, bishop Seraphim, D-r Geogry Mirovich and other create the first society of the Red Cross. With co-operation of P.R. Slaveikov, publish the first Bulgarian newspaper in Sliven "Bulgarian flag". His public activity was illuminate as like as people "representative and functionary of the United".

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M Todorova, I Triphonov. [Not Available].. https://pubmed.ncbi.nlm.nih.gov/11624525/

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IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.

It has been hypothesized that insulin-like growth factors (IGFs) and components of the growth-hormone (GH)-IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH-IGF system--the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein-3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia.

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