Deconstructing Golgi inheritance.

O W Rossanese; B S Glick

doi:10.1034/j.1600-0854.2001.20901.x

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PubMed · 11555412

Deconstructing Golgi inheritance.

O W Rossanese·B S Glick

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Abstract

Eukaryotic cells use a variety of strategies to inherit the Golgi apparatus. During vertebrate mitosis, the Golgi reorganizes dramatically in a process that seems to be driven by the reversible fragmentation of existing Golgi structures and the temporary redistribution of Golgi components to the endoplasmic reticulum. Several proteins that participate in vertebrate Golgi inheritance have been identified, but their detailed functions remain unknown. A comparison between vertebrates and other eukaryotes reveals common mechanisms of Golgi inheritance. In many cell types, Golgi stacks undergo fission early in mitosis. Some cells exhibit a further Golgi breakdown that is probably due to a mitotic inhibition of membrane traffic. In all eukaryotes examined, Golgi inheritance involves either the partitioning of pre-existing Golgi elements between the daughter cells or the emergence of new Golgi structures from the endoplasmic reticulum, or some combination of these two pathways.

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Animals Biological Transport Cell Cycle Proteins Endoplasmic Reticulum Fungi Golgi Apparatus Mitosis Models, Biological Plant Physiological Phenomena Protein Kinases Protein Serine-Threonine Kinases Proto-Oncogene Proteins Polo-Like Kinase 1 Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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O W Rossanese, B S Glick. 2001. Deconstructing Golgi inheritance.. https://doi.org/10.1034/j.1600-0854.2001.20901.x

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