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Biomedical subjects

Z Papp

Publications and source records attributed to Z Papp.

At least 253 records · Page 14Linked to original sources
PubMed1987

Prenatal diagnosis policy without routine amniocentesis in pregnancies with a positive family history for neural tube defects.

The recurrence risk for neural tube defects in pregnancies of women with a family history of neural tube defects greatly exceeds the general population risk. In these high risk pregnancies, we used a prenatal diagnostic method differing from that usually employed, relying mainly on the results of maternal serum alpha-fetoprotein (MSAFP) and ultrasound examination, without routine amniocentesis. During the 6 years reviewed in this study, this method was applied in 539 pregnancies. Of a total of 20 neural tube defects, 19 were detected using this combination of MSAFP, ultrasound, and selective amniocentesis, and the authors estimate that about 8-10 spontaneous abortions were avoided because only 28 amniocenteses were carried out instead of 539. The risk of recurrence was found to be lower than that experienced earlier.

Amniocentesis↗
PubMed1987

Immunocytochemical characterization of amniotic fluid macrophages in cases of fetal neural tube defects.

Amniotic fluid cells from 31 pregnancies with fetuses having open neural tube defects (NTDs) and from 43 pregnancies with fetuses free of NTDs were studied with the use of the immunoperoxidase method for alpha-fetoprotein (AFP) and glial fibrillary acidic protein (GFAP). The authors also used cytochemical stains for endogenous peroxidase and nonspecific esterase activity. In cases of NTDs, macrophages were present in the amniotic fluid, and in the authors' system they showed intense immunoreactivity for both AFP and GFAP and showed very strong activity for peroxidase and nonspecific esterase, whereas the epithelial cells and red blood cells showed no activity. In six cases of anencephaly, sections from the margin of the cranial end of defective spinal cords at the aperture of the open lesion were also studied for AFP and GFAP. In these cases, AFP- and GFAP-positive cells were found, indicating the possible neural (glial) origin of a part of amniotic fluid macrophages. Although the determination of AFP levels in maternal blood and amniotic fluid is widely used in the prenatal diagnosis of NTDs, demonstration of AFP in amniotic fluid cells by means of immunocytochemistry has not been described.

Amniotic Fluid↗
PubMed1987

Prenatal diagnosis of X linked hydrocephalus without aqueductal stenosis.

The outcome of four successive pregnancies in a woman heterozygous for X linked hydrocephalus is described. The last two were scanned by ultrasound. In one, a good prognosis was given; the fetus was male but there was no evidence of dilated cerebral ventricles. In the other, hydrocephalus was diagnosed. The absence of aqueductal stenosis in this case supports the hypothesis that in this X linked condition communicating hydrocephalus is the primary defect and aqueductal stenosis is secondary.

Adult↗
PubMed1987

Amniotic bands associated with early rupture of amnion due to an intrauterine device.

Amniotic bands in consequence of early rupture of amnion-membrane was found in a spontaneously aborted gestational sac. This case seems to confirm the theory that amniotic bands develop due to amnion rupture principally caused by exogenous less frequently by endogenous factors. In the reported case the exogenous factor was an intrauterine device, the resulting inflammation presumably responsible for rupture of amnion.

Abortion, Spontaneous↗