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Biomedical subjects

Z Papp

Publications and source records attributed to Z Papp.

At least 235 records · Page 13Linked to original sources
PubMed1989

Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy. A case report.

A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.

Adult↗
PubMed1989

Routine prenatal screening policy of fetal malformations by both maternal serum alpha-fetoprotein and ultrasound in eastern Hungary.

Since January 1979, at our Genetic Counselling Unit in Debrecen all pregnancies at high risk for any reason have been screened sequentially by serum alpha-fetoprotein estimation (at the 16th week) and by ultrasound examination (18th week). This screening policy covered 1200-1500 consultations per year. From July 1983, the same prenatal screening policy has been extended to cover the whole pregnant population of two large counties in Eastern Hungary. In a six-year period over 300 fetal malformations were diagnosed. Details of the screening policy and the main groups of malformations diagnosed prenatally are demonstrated.

Congenital Abnormalities↗
PubMed1989

[Effect of Chinoin-103 on Na+, K+-activated adenosine triphosphatase of the rat heart].

Effect of a new beta-blocking agent, a cardioselective aryl oxybutanolamine derivative, the Chinoin-103 on basal and total ATP-aze activities has been studied in total homogenizatum of rat heart. The effect has been compared to previous results of propranolol and to effect of practolol, respectively. It has been established that DL-Chinoin-103-similarly to DL-propranolol but in a little higher concentration--has significantly impeted both basal and total ATP-aze activities. Since in the nase of practolol similar effect was not obsreved and furthermore the effect could not be suspended by isoproterenol, the authors suppose that impediment of sarcolemmal ATP-aze activities cannot primarily be attributed to beta-blocking effect of compounds. Study of effect of racemic Chinoin-103 on enzymatic kinetic parameters of basal and total ATP-aze acticities has shown that primarily the reaction rate had decreased, affinity to substratum had not changed in the case of total ATP-aze and it has moderately decreased in the case of basal ATP-aze. The results of this publication has drawn attention to the fact that some beta-receptor blocking compounds may have other specific membrane effects besides antagonism on beta-receptors.

Adenosine Triphosphatases↗
PubMed1989

Effect of selenium, vitamin E and riboflavin supplementation of the feed on the humoral and cell-mediated immune responses of growing pigs.

The feed of weaned piglets of Hungarian Large White X Duroc and Dutch Landrace X Duroc genotype was supplemented with 0.5 mg selenium, 50, 100 or 150 mg vitamin E, and 2.5 or 5 mg riboflavin per kg. Feed supplementation enhanced the cytotoxic reaction and elevated the antibody titres produced against purified horse gamma globulin antigen. However, as compared to the control the differences were not significant. Feed supplementation exerted a beneficial, though varying, influence on the indices of cell-mediated immunity. The proportion of rosette-forming cells and blastogenic transformation induced by specific (horse globulin) and nonspecific (phytohaemagglutinin, PHA) mitogens underwent the most expressed and most significant increase in pigs fed 5 mg selenium, 100 mg vitamin E and 5 mg riboflavin per kg of feed. On the other hand, feed supplementation failed to enhance the responsiveness to intradermal PHA (type IV allergic reaction).

Animal Feed↗
PubMed1989

Characterization of rapidly adhering amniotic fluid cells by combined immunofluorescence and phagocytosis assays.

Culture of human amniotic-fluid cells from cases of fetal neural tube defects produces a population of rapidly adhering cells that were initially thought to be macrophages and later interpreted to be of neural origin. In this study double and triple labeling systems for the simultaneous detection of glial and macrophage differentiation marker antigens have been used to demonstrate that rapidly adhering cells cannot be considered a homogeneous population but instead represent two distinct cell types. One of these cell populations is of glial origin and shows specific staining for glial fibrillary acidic protein, while the other population is monocyte-derived macrophages which express marker antigens recognized by Leu M3, KiM7, and Dako antimacrophage monoclonal antibodies.

Amniotic Fluid↗
PubMed1989

Prenatal diagnosis and management of chondrodysplasias.

Thorough ultrasound examination of fetal limbs and fetal movements allows us to recognize several types of osteochondrodysplasia, both in high risk pregnancies (with a family history of chondrodysplasia) and up on routine screening. Correct diagnosis of growth retardation requires nomograms for bone length, and we have developed our own standards for the humerus, ulna, femur and tibia. Since some types of osteochondrodysplasia are compatible with life and others not, it is important to make the correct diagnosis using several differential diagnostic criteria. Only in this way can we decide the further management of a pregnancy. At our Prenatal Diagnosis Centre 8 cases of osteochondrodysplasia have been diagnosed. We discuss the differential diagnosis and the pregnancy management for some of these cases.

Adult↗
PubMed1988

Heterogeneity and recurrence risk for congenital hydrocephalus (ventriculomegaly): a prospective study.

We report on 261 prospectively ascertained pregnancies studied to determine the recurrence risk of congenital hydrocephalus. Our results suggest that couples who have had one previous child with hydrocephalus have a recurrence risk of 4%. Such couples should be offered prenatal diagnosis in the second trimester of all subsequent pregnancies. It is suggested that, apart from the X-linked recessive cases, ventriculomegaly is mostly multifactorially determined.

Genetic Counseling↗
PubMed1988

Neutral-red uptake and expression of monocytic antigens in amniotic-fluid mononuclear phagocytes: evaluation of a novel approach for prenatal diagnosis of neural-tube defects.

In cases of fetal neural-tube defects macrophages are present in the amniotic fluid. We found that these viable phagocytic cells take up neutral-red and are easily identified as "red cells" by microscopic examination. This method is suitable for the rapid identification and counting of amniotic-fluid macrophages in suspension. We have studied 298 amniotic fluid samples. In the 226 normal cases studied, 0 to 1,200 macrophages per milliliter amniotic fluid have been found. In contrast, we found 1,250 to 99,000 macrophages per milliliter amniotic fluid in our 70 open neural tube defect (ONTD) cases. Statistical evaluation was performed to estimate the normal and pathologic ranges. Specificity and sensitivity of the neutral-red test and predictive value of positive and negative results have been calculated and presented in comparison with alpha-fetoprotein (AFP) determinations and ultrasonic methods. In 5 cases of anencephaly and 7 normal cases amniotic fluid cells were studied by immunocytochemistry: mononuclear cells present in the abnormal cases showed intense immunoreactivity for the Mo1 and Mo2 surface antigens of the phagocytic cell lineage.

Amniotic Fluid↗
PubMed1988

Relationship between placentation and maternal serum alpha-fetoprotein in twin pregnancies.

Maternal serum alpha-fetoprotein (MSAFP) concentration is raised in twin pregnancies during the second trimester. The approximate doubling of seAFP level in uncomplicated twin pregnancies seems logical, considering the doubled fetal source of AFP, even though the seAFP level is not always increased in twin pregnancies. What factors can influence this phenomenon? With this in mind, we have examined the seAFP concentration in 90 successive twin pregnancies with known outcome. The relationship between seAFP level and the type of placentation is demonstrated.

Birth Weight↗
PubMed1988

Pathological consequences of the vanishing twin.

Fetus papyraceus is a mummified, compressed fetus occurring in association with a viable twin. The death of the fetus usually occurs early in the second trimester. A co-twin dying earlier may be absorbed completely, whilst later fetal death usually results in macerated, but not compressed fetuses. This course of events can be well demonstrated by ultrasonography. The death of one fetuses may be associated with minor malformations of the surviving one. After termination of twin pregnancies the detailed check-up of the newborn and histopathological examination of the placenta is essential.

Female↗
PubMed1988

Prenatal diagnosis by ultrasound of midface defects associated with holoprosencephaly.

Authors present cases of cyclopia, cebocephaly associated with holoprosencephaly, diagnosed prenatally by ultrasound. A detailed description of ultrasound findings is given. When intracranial anatomy appears abnormal, the orbits must be visualized, the interorbital diameter must be measured and facial malformations should be looked for.

Abnormalities, Multiple↗
PubMed1988

Immunobiological methods in the prenatal diagnosis and evaluation of foetal neural tube defects.

In cases of foetal neural tube defects (NTDs) macrophages are present in the amniotic fluid. These mononuclear cells were analysed with immunobiological methods: functional markers as Fc and C3b receptor-mediated phagocytosis and chemoluminescence have been studied. It was found that most of these pathognomic cells ingest haemolysin sensitized sheep red blood cells (sSRBCs) and zymosan (Mannozym) particles opsonized with fresh human serum. Amniotic fluid cell suspensions from pregnancies with and without foetal NTDs were stimulated by opsonized Mannozym; consistently higher chemoluminescence activities were found when open lesion was present. The evaluation of multiple functional markers is likely to provide a better basis for understanding the characteristics of amniotic fluid macrophages and may contribute to the prenatal diagnosis of NTDs.

Amniocentesis↗