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Biomedical subjects

Z Dienstbier

Publications and source records attributed to Z Dienstbier.

At least 127 records · Page 7Linked to original sources
PubMed1977

Uracil metabolism in golden hamster after irradiation.

The catabolism of uracil and the total balance of excreted radioactivity were studied in golden hamsters after a peroral application of 14C-uracil. Twenty-four hours after administration most of the radioactivity taken up appeared in expired carbon dioxide. The percent proportion of radioactivity in carbon dioxide was independent of the amount of uracil administered. On the other hand, the percentage of radioactivity excreted in urine depended on the amount of uracil taken up, high doses of the compound causing up to eight-fold increase in urine-excreted radioactivity. Most of the exogenously-administered uracil was catabolized within the first 5 hours. Irradiation had no substantial effect on the dynamics of uracil catabolism. Analysis of urine revealed that most urine-excreted radioactivity is in the form of uracil. On peroral application of high doses of uracil to irradiated hamsters, their urine was found to contain barbituric acid which originated from uracil.

Animals↗
PubMed1977

Changes of the activity of certain lysosomal enzymes in the blood serum of whole-body irradiated rats.

The activities of acid phosphatase, beta-glucuronidase, beta-galactosidase, acid ribonuclease, and acid deoxyribonuclease were studied in the blood serum of rats after total, either single or franctionated, exposure. After the single, total exposure to 800 R of X-rays, remarkable increases in the activities of acid phosphatase and acid deoxyribonuclease were observed in the blood serum immediately after the irradiation. At later stages were observed statistically significant decreases of beta-glucuronidase and beta-galactosidase in the rat blood serum after the total, single exposure. The serum acid ribonuclease activity remained essentially unaltered over the whole time interval of interest. In the blood serum of the rats exposed to total, fractionated irradiation, statistically significant decreases in the acid phosphatase and beta-glucuronidase activities were observed 1 and 8 days after completing the irradiation. In the case of beta-galactosidase, this decrease lasted even up to the 15th day after the end of irradiation. The activities of serum acid deoxyribonuclease and acid ribonuclease exhibited no statistically significant changes.

Acid Phosphatase↗
PubMed1977

Changes of the antiheparin activity of the blood plasma and lymph in dogs after total irradiation.

An increase was demonstrated of the antiheparin activity in the blood of rats after their total exposure to 200, 500 and 800 R and dogs exposed to 400 R. In the rats the increase of the antiheparin activity was directly dependent of the exposure used. The antiheparin activity increased up to 180 min after the exposure. In the irradiated dogs, there was also a strong increase in the antiheparin activity with a certain decrease 24 hrs after irradiation. A secondary increase was observed on the 7th, 10th and 13th days of the experiment. In the lymph of the irradiated dogs, the increase of the antiheparin activity was steeper than that in the blood itself. The results achieved could serve as a starting point for further investigations to answer the question of possible using these changes for diagnostic estimation of the biological degree of the radiation damage under different conditions.

Animals↗
PubMed1977

Changes in the activity of certain lysosomal enzymes in the blood serum of rats subjected to whole body x-ray irradiation.

In summing up, we find that only serum acid phosphatase activity rose immediately, and beta-galactosidase activity 6 hours, after whole body irradiation, in each case after an exposure dose of 800 R. At the other intervals, the three enzyme activities studied either remained unchanged or were statistically significantly lowered. The most pronounced decrease was found in serum beta-galactosidase and serum beta-glucuronidase activity on the 3rd, 5th and 7th day after exposure.

Acid Phosphatase↗
PubMed1976

Isotope lymphography of the retrosternal region.

The authors have examined 150 patients with Hodgkin's lymphomas and cancer of the breast and lung. They consider indirect lymphography as a screening method necessary to be completed with available clinical examinations. In normal scintigram it is possible eliminate the pathological process. Even when some part of lymphatic region is not scanned it is possible to say that the suspicion of a pathological process is highly probable. It is necessary to consider the anatomical variability of lymphatic vessels. Therefore, the scintigram must be evaluated together with other clinical findings. The examination of axillar and cervical area of lymphatic system and the determination of eventual collateral circulation is recommended simultaneously with retrosternal lymphography.

Breast Neoplasms↗
PubMed1976

Distribution and behavior of isoselenouronium salts in the body. V. Acute toxicity and metabolic fate of selenium derivatives.

The acute toxicity of AESe, 2-ASe, and Se-MEG was estimated in mice after i.v., i.p. and s.c. application. In all forms of application, 2-ASe was found to have the lowest toxicity. The study of excretion showed that administered compounds are excreted practically completely within seven days, mostly by urine. The excretion by faeces is very low and by exhalation is under the threshold of demonstrability. The metabolism of 2-ASe is slow, most of it is excreted without any change; AESe is transformed into a mixture of 2-ASe and Se-MEG. Se-MEG is excreted by urine totally metabolized as trimethylselenium ion.

Acute Disease↗