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Biomedical subjects

Z Dienstbier

Publications and source records attributed to Z Dienstbier.

At least 109 records · Page 6Linked to original sources
PubMed1979

Significance of biochemical markers in Morbus Hodgkin.

Statistically significant changes of the values of biochemical tests can be utilized in complex clinical and laboratory diagnosis and in appreciating the status of the disease in Hodgkin's lymphomas. Considering the increasing number of biochemical tests and their common nonspecificity, urgent necessity appears to verify their importance in malignant diseases. The authors analyzed 2626 biochemical examinations in 39 patients with M. Hodgkin. The results were evaluated in untreated patients, in patients in remission with and without BCG vaccination, in relapse, in the course of successful and unsuccessful therapy and the contribution of individual laboratory tests for the diagnosis and the course of the disease was verified. Suitable for the diagnosis are those tests which do not deviate from physiological limits in the sense either of the increase (alpha 2-, beta-, gamma-globulins and transaminases) or the decrease (albumins and albumin-globulin quotient). Statistically insignificant were the changes of the values of total protein, alpha1-globulins, N-urea, thymol turbidity reaction, cholesterol, phosphatases and lactate dehydrogenase. The results presented can be an aid for the clinician in the choice of individual biochemical markers.

Adolescent↗
PubMed1978

Scintigraphic methods in the diagnosis of M. Hodgkin.

The authors examined 40 patients with Hodgkin's lymphoma suspected from the localization of the process in mediastinum. They used X-ray investigation, radioisotope lung perfusion, radiogold-colloid lymphography and 67Ga-citrate scintigraphy. They found that, when the disease was diagnosed, X-ray examinations including tomography and lung perfusion gave reliable information in only half the cases whereas the other two nuclear medical methods showed positive results in 88% and 82%, respectively. In the diagnosis of relapse, the yield of these former methods was substantially higher, between 82--90%.

False Negative Reactions↗
PubMed1978

Immunoglobin levels in patients with Hodgkin's disease.

The authors examined a course of immunoglobulin values (IgA, IgG, IgM) in 40 patients with the Hodgkin's disease and repeatedly in 11 healthy persons. In the patients they followed the levels of the immunoglobulins during the disease, up to 5 years. In untreated patients there were statistically significant increased IgA levels and insignificant increase of IgG. In the course of remission the immunoglobulin values were normalized. The radiotherapy did not affect significantly the value of immunoglobulins, the combined chemotherapy (COPP) led to a drop of this level. The levels of immunoglobulins are recovered after chemotherapy in the case of successful treatment. In terms of the prognosis the authors consider as unfavorable high increase in the immunoglobulin levels in untreated patients and their rapid drop during the chemotherapy. They observed an average preterminal drop of the IgA by 27%, IgG by 23% and IgM by 44% with respect to controls.

Adult↗