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Biomedical subjects

Z Dienstbier

Publications and source records attributed to Z Dienstbier.

At least 145 records · Page 8Linked to original sources
PubMed1976

Distribution and behavior of isoselenouronium salts in the body. VI. Comparative study of distribution and radioprotectivity of selenium derivatives.

The protective effect of AESe, 2-ASe, and Se-MEG during irradiation with a dose rate of 500 R/min was followed. The protective effect of 2-ASe is substantially lower during the dose rate of 20 R/min and even during an increased dose. AESe and Se-MEG are noneffective. The time of duration of the protective effect of 2-ASe corresponds to the period of its high concentration in the organism after the administration, i.e. ca. 45 min.

Animals↗
PubMed1976

Excretion of Dische positive compounds in rats after irradiation and after administration of some cytostatic drugs.

In order to verify some pathophysiological aspects in radio- and chemotherapy of tumors the excretion of Dische positive compounds in rats was followed. During fractionated whole-body irradiation of animals it was found that up to the exposure with 50 R/day the organism is able to repair the disturbances provoked by irradiation for a certain time and that within the course of irradiation a permanently higher excretion of Dische positive compounds occurs. On the contrary, following the exposure of 100 R/day after a short increase continual decrease occurs lasting until the death of the animal. The excretion of Dische positive compounds in rats was followed also after the application of Cyclophosphamide, cis-dichlorodiammineplatinum (II) and Vinblastine. All these three cytostatic drugs produce an increased excretion of Dische positive compounds on the first day after the application. In the case of Cyclophosphamide, it was demonstrated that the excreted amount of Dische positive compounds was dose dependent.

Animals↗
PubMed1975

Urine excretion of nucleosides in Hodgkin's disease treated by combined chemotherapy.

The authors have followed the excretion of pyrimidine doexyribonucleosides in the urine of patients with generalized stages of Hodgkin's disease. They proved an increased excretion of deoxyuridine and thymidine in these patients compared to healthy persons. In the course of 14-days of combined chemotherapy a statistically significant increase in the excretion of DNA catabolites followed was found.

Cyclophosphamide↗
PubMed1975

An assay of biological dosimetry from the changed number of lymphocytes and hypersegmented neutrophiles evaluated by means of statistical decision method.

The paper presented deals with the statistical utilization of changes in lymphocyte and hypersegmented neutrophiles counts in peripheral blood after irradiation for the biological detection of ionizing radiation. Both followed-up parameters are in a good correlation during simultaneous evaluation of their changes, and they fail during evaluation in various time intervals after irradiation. The changes of two hematological parameters after irradiation, lymphopenia and hypersegmentation of cellular nuclei of granulocytes were therefore utilized. The changes under examination were elaborated in the computer and avaluated by method of regression classification and by discriminatory analysis. This analytical way enables a new conception during the evaluation of individual hematological post-irradiation changes. This study is being continued in several lines. On the one hand, further statistical methods of making the results more precise will be used, on the other hand, other laboratory animals will be tested as well. Last but not least, the best statistical method will be used in an attempt to detect biologically the changes after the therapeutical irradiation in man.

Animals↗
PubMed1975

Distribution and behaviour of isoselenium salts in organism. III. Radioprotective effect of selenium derivatives.

Radioprotective properties of Se-2-aminoethylioselenouronium bromide hydrobromide, 2-aminoselenoazoline and of selenium analogue of mercaptoethylguanidine were followed. Radio-protective effectiveness comparable with classical thiol radioprotectiva was manifested by 2-aminoselenoazoline. In the other two compounds there was on the contrary found a synergism of toxicity and radiation.

Animals↗