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Biomedical subjects

Y Tanizaki

Publications and source records attributed to Y Tanizaki.

At least 109 records · Page 6Linked to original sources
PubMed1985

Decrease in reactivity of basophils by immunotherapy with housedust extract.

Changes of basophil reactivity to housedust extract and anti-IgE during immunotherapy was examined in thirteen patients with bronchial asthma sensitive to housedust. (i) A significant decrease in the morphological reactivity of basophils to housedust extract was observed 6 months after the beginning of immunotherapy with the antigen, and a significant decrease after 12 and 18 months' therapy, accompanied with the decrease of histamine release from the cells. The percent reactive basophils to the antigen decreased from 59.2 +/- 2.9% before the therapy to 40.0 +/- 1.8% after 18 months' immunotherapy. (ii) A decrease in the morphological reactivity of basophils to anti-IgE was also shown during immunotherapy. The basophil reactivity to anti-IgE decreased significantly at the late stage (18 months) of immunotherapy. (iii) A significant reduction of specific IgE antibody to housedust was observed 12 and 18 months after the beginning of immunotherapy. It was suggested from these results that immunotherapy causes some changes on the surface of basophils and decreased reactivity of the cells, and that a decrease of reactive basophils to anti-IgE in the process of immunotherapy might be due to a decrease in number of IgE receptors essentially or functionally.

Adolescent↗
PubMed1985

New CT-guided stereotactic apparatus and clinical experience with intracerebral hematomas.

The conventional Sugita stereotactic frame has been improved to perform CT-guided stereotactic surgery both in the CT and operating rooms. The development of our instrument and the software of the scanners' computer are presented. Newly designed equipment produced almost no artifacts on the CT image. Using the improved stereotactic frame, we have operated upon 44 intracerebral hematomas in the CT room. More than 80% of the cases had satisfactory results. Two complications were encountered, and 1 patient died from pneumonia. Our initial experience of the pre- and postoperative cerebral blood flow measurement with 133Xe inhalation method and single photon emission CT is described.

Cerebral Hemorrhage↗
PubMed1985

The calcium antagonist, nicardipine, inhibits antigen-stimulated and anti-IgE-induced histamine release from basophilic leucocytes of atopic asthmatics.

The inhibitory effect of nicardipine, a calcium antagonist, on the antigen- and anti-IgE-induced histamine release from basophilic leucocytes of patients with bronchial asthma was examined. The agent significantly inhibited both antigen-stimulated and anti-IgE-induced histamine release from basophils (the maximum percent inhibition was 57.8 +/- 7.2% and 56.0 +/- 8.8%, respectively). Pre-incubation of basophils with nicardipine for periods of up to 120 min did not alter the inhibitory effect. These results suggest that nicardipine modifies the histamine release from basophils which closely participate in an attack of bronchial asthma.

Antibodies, Anti-Idiotypic↗
PubMed1985

Comparison of basophil histamine release induced by the cross-linking of IgE receptors.

Basophil histamine release induced by allergens (house dust and Candida albicans) and anti-IgE was examined in 31 patients with bronchial asthma in relation to patient age, age at onset of the disease and serum IgE levels. Basophils from patients under 40 years of age generally released a significantly large amount of histamine by stimulation with house dust and anti-IgE. On the other hand, histamine release from patients over 41 years of age was generally not marked when the cells were incubated with house dust and anti-IgE, although, in some cases, the release induced by C. albicans was fairly marked. Basophils from patients under 30 years of age at onset were reactive to house dust and anti-IgE, while the cells from patients over 41 years of age at onset tended to be reactive only to C. albicans. Basophils from patients with low serum IgE levels were less reactive than the cells from patients with high levels of IgE to house dust and anti-IgE. C. albicans-induced release of histamine did not correlate with serum IgE levels.

Adult↗
PubMed1985

Candida-induced histamine release from basophils: relationship to house dust- and anti-IgE-induced secretion.

Candida albicans-induced histamine release from basophils was studied in 54 patients with bronchial asthma in comparison with the release caused by house dust and anti-IgE. The release of histamine induced by C. albicans and that induced by house dust were closely related to the serum levels of specific IgE antibodies as expressed by RAST scores. A correlation of C. albicans-induced histamine release with the release caused by anti-IgE was not generally observed. On the other hand, a close correlation was found between house dust- and anti-IgE-induced histamine release. It was suggested from these results that the differences between C. albicans- and house dust-induced histamine release might be due to the different antigenicity of the two allergens.

Adolescent↗
PubMed1985

Retraction system for transsphenoidal surgery. Technical note.

A retraction system has been developed for transsphenoidal surgery to use together with a conventional self-retaining speculum. The system comprises an attachment to the speculum, a self-retaining retractor, and a slim tapered brain spatula and pronged hook. The spatula or hook is secured with the self-retaining retractor and the attachment. The retractor can also be fixed to the Sugita multipurpose head frame. The system may be used to retract the bulging diaphragma sellae and tumor tissues, and to stop bleeding from the dural venous sinus or tumor bed, so the surgeon can continue the procedure with both hands.

Adenoma↗
PubMed1985

[An autopsy case of primary malignant melanoma of the ovary].

This report presents the first patient in Japan with primary malignant melanoma of the ovary. The patient was a 62-year-old woman with the complaint of progressive left hemiparesis due to metastatic brain tumor. She died in the course of two months. At autopsy, there was a large tumor containing brownish fluid at the right ovary. The inner lining of the tumor was covered with a black friable mass with hairs. Histologically, the tumor was composed of polygonal, melanotic or amelanotic cells. Metastases were found in the cerebrum, uterine cervix, etc. In conclusion, the tumor was thought to be malignant melanoma arising in a dermoid cyst. This is an extremely rare condition, reported in only 12 cases throughout the world. The histological findings and histogenesis are presented and discussed.

Brain Neoplasms↗
PubMed1984

Allergen- and anti-IgE-induced histamine release from whole blood.

The release of histamine by allergen and anti-IgE from whole blood was observed in 34 asthmatic subjects with a positive skin test to house dust. The time course of histamine release showed that the release by allergen and anti-IgE peaked after 15 min incubation. There was no significant difference in the time course of the release from whole blood between allergen and anti-IgE. Anti-IgE-induced histamine release correlated to a certain extent with the serum IgE level. Histamine release by house dust, on the other hand, correlated with the radioallergosorbent test score. A striking difference was present in the dose-response slope between allergen and anti-IgE. The maximum percent release correlated with the dose-response slope by allergen, but not by anti-IgE. The amount of histamine release induced by anti-IgE paralleled the amount of the release by house dust in the cases sensitive to the allergen; less sensitive basophils to anti-IgE were less sensitive to house dust.

Adolescent↗
PubMed1984

In vitro antigen-induced increase in motility and degranulation of basophilic granulocytes from atopic asthmatics, studied by microscopic motion pictures.

Increase in motility and degranulation of basophilic granulocytes by stimulation with antigen were studied by phase-contrast microscopic motion pictures. There was no difference in random movement between sensitized (atopic asthmatics) and nonsensitized basophilic granulocytes (healthy subjects). The incidence of basophilic granulocytes with oriented movement before antigen stimulation was significantly lower in atopic asthmatics compared to that in healthy subjects, but was significantly increased at 3-6 min and reached the peak at 12-15 min after addition of antigen. Degranulation of sensitized basophilic granulocytes began to occur at 3-6 min with the maximum at 12-15 min after antigen stimulation.

Asthma↗
PubMed1984

Effect of a serum factor on IgE-mediated histamine release from whole blood.

IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. The maximum histamine release from whole blood induced by anti-IgE correlated with total serum IgE levels. There was a close correlation between allergen-induced release from whole blood and the serum levels of specific IgE antibodies. In the maximum histamine release from whole blood induced by both anti-IgE and allergen, the interaction with a serum factor was not clearly recognized. Effect of a serum factor was shown in the dose-response curves of anti-IgE-induced histamine release, but not in those of allergen-induced histamine release. The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. The results showed that IgE molecules contained in the serum participate in anti-IgE-induced histamine release from whole blood.

Adolescent↗
PubMed1984

Blood eosinophilia in bronchial asthma and its relationship to IgE-mediated reactions.

The correlation between blood eosinophilia and anti-IgE-mediated histamine release was investigated in 22 bronchial asthma patients with peripheral eosinophilia (over 8%). In the cases (Group A-1 and Group A-2) in which house dust was the specific antigen, significant histamine release from basophils was induced by anti-IgE and house dust. The result indicates a relationship between eosinophilia and the IgE-mediated mechanism of disease onset. In the cases (Group A-3) with RAST scores of 0+ and 1+ to house dust, the anti-IgE-induced histamine release varied from low to high percentages, and the participation of the IgE-mediated pathway was indicated in some cases. In the cases (Group B) with negative skin reactions, few patients had a family history of allergic disease. Their ages at onset were higher, and they demonstrated lower total IgE levels. These cases showed an extremely low percent of histamine release from basophils, which indicated the absence of a correlation between eosinophilia and IgE-mediated mechanisms.

Adolescent↗
PubMed1984

Classification of asthma based on clinical symptoms: asthma type in relation to patient age and age at onset of disease.

Seventy-one cases of bronchial asthma were classified into three types: bronchospasm, bronchospasm-hypersecretion and bronchiolar obstruction types. The characteristics of each type were studied in relation to patient age and age at onset of the disease. In the 71 subjects studied, the most frequent type was the bronchospasm type followed by the bronchospasm-hypersecretion type and bronchiolar obstruction type. Intractable asthma was most frequently observed in the bronchiolar obstruction type and least in the bronchospasm type. Most of the patients under 50 years of age showed the bronchospasm type. The bronchospasm-hypersecretion type was characteristically accompanied by blood eosinophilia when the patient age was under 50 years. In the bronchospasm-hypersecretion type, the incidence of intractable asthma was high in patients under 50 years of age, but not remarkable in those over 50. A large proportion of the patients over 50 years of age were of the bronchiolar obstruction type. There was no difference in the incidence of intractable asthma between the two groups classified by age at onset.

Adolescent↗