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Biomedical subjects

Y Murakami

Publications and source records attributed to Y Murakami.

At least 991 records · Page 55Linked to original sources
PubMed1981

Laryngeal carcinoid tumor: light and electron microscopic studies.

A case of laryngeal carcinoid in a Japanese 76-year-old man is reported. This neoplasm is extremely rare in the larynx and the case is the fourth so far reported in the world medical literature. Light and electron microscopic studies revealed argyrophilia and the presence of neurosecretory granules that had not been demonstrated in the previous cases. A review of the medical literature showed that all laryngeal carcinoids were pathologically malignant. The relationship of carcinoid tumor to oat cell carcinoma of the larynx is discussed, and the suggestion is made that a similar relationship exists between them as between carcinoid tumors and oat cell carcinomas of the lung.

Aged↗
PubMed1981

Role of pancreatic hormones in dietary induction of ornithine decarboxylase of rat liver.

1. Although the mean ornithine decarboxylase (ODC) activity induced by feeding in alloxan-diabetic rats was 60% of that in normal rats, it was markedly suppressed in pancreatectomized rats depending on the degree of pancreatectomy. 2. There was a correlation between plasma glucagon concentration and hepatic ODC activity under various dietary conditions. 3. When glucagon or insulin was given to pancreatectomized rats, dietary induction of ODC was restored to a level found in normal rats. The effects of glucagon and insulin were not additive, suggesting that these hormones act with a similar mechanism. Feeding 75% casein diet resulted in a considerable induction of ODC even in pancreatectomized rats. The enzyme was only slightly induced, however, when pancreatic hormones were given to starved rats. 4. Findings from amino acid analysis indicated that the influx of some amino acids into liver was stimulated by administration of glucagon. 5. These results suggest that increased influx of amino acids into liver is a critical factor for dietary induction of ODC and that both glucagon and insulin play a role in stimulating amino acid influx.

Adrenalectomy↗
PubMed1981

Rat liver ornithine decarboxylase purification and some immunochemical studies.

Ornithine decarboxylase [EC. 4.1.1.17] was purified 3.5 X 10(5)-fold with an overall yield of 8% from livers of rats treated with thioacetamide and DL-alpha-hydrazino-delta-aminovaleric acid. The enzyme preparation was homogeneous as judged by three criteria, namely polyacrylamide gel electrophoresis with or without sodium dodecyl sulphate and Ouchterlony double immunodiffusion analysis. The final specific activity was 1.1 X 10(6) nmol/h mg protein, which closely coincided with the value predicted by Pritchard et al. (16). The enzyme was composed of two identical subunits and the molecular weight was estimated to be 105,000 by polyacrylamide gel electrophoreses at several different gel concentrations. It was shown by an immunochemical method that diet-induced change in hepatic ornithine decarboxylase activity was due mostly, if not totally, to the change in the amount of enzyme protein.

Animals↗
PubMed1980

H-reflex of the upper extremities in cervical myelopathy.

A study was made of the H-reflex in the upper extremities to express objectively the degree of spastic paralysis in cases of cervical myelopathy. This reflex cannot normally be elicited in healthy persons. The H-reflex was elicited in 63 out of 80 patients with advanced symptoms of cervical myelopathy and was most frequently recorded from the median nerve. The H/M amplitude ratio is used to express the degree of spastic paralysis, the higher the ratio the more severe the dysfunction. The longer the clinical history the greater the tendency for the H-type of reflex to change to the HF-type and the higher the H/M amplitude ratio. The decrease rate of the pre- and post-operative H-reflex was high amongst soft disc cases whilst that in spondylosis and ossification of the posterior longitudinal ligament was low compared to the improvement in symptoms. It is concluded that the H-reflex in the upper extremities is a good method of expressing the degree of spastic paralysis in cervical myelopathy.

Aged↗