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Biomedical subjects

Y Kubo

Publications and source records attributed to Y Kubo.

At least 379 records · Page 21Linked to original sources
PubMed1985

[Superior facet syndrome--findings on metrizamide CT myelography].

Sciatica caused by root entrapment in the lateral recess was named superior facet syndrome by Epstein in 1972. Few reports on this subject based on large numbers of cases have been documented to date. Of the patients with sciatica, 32 patients were diagnosed to have root entrapment at the lateral recess L5 or/and S1 lumbar spine. Out of 32 patients, 20 patients were operated on and the lateral entrapment was recognized in all of surgical cases. Neuroradiological findings, especially of metrizamide CT (met. CT), were documented in detail. Thirty two patients were classified in three types according to radiological findings. They were congenital or developmental, degenerative, and combined type, respectively, Fourteen cases belonged to the congenital type, 13 to the degenerative and 5 to the combined type. Each group had the mean ages of 23.4, 53.8, and 36.8 years old, respectively. Of 32 cases the entrapment occurred in 47 L5 roots and 11 S1 roots. There was no remarkable laterality. In operation the unroofing of the lateral recess were done and the sciatica subsided postoperatively in all of surgical cases. Met. CT revealed extreme medial protrusion of the superior articular joint in 18 of 24 cases (75%) and none filling of the root in the lateral recess in 21 of 24 cases (87.5%). In the degenerative type, met. CT showed some degenerative changes that were hypertrophy or deformity of the articular joints and spur formation of the vertebral body.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Teratogenicity of thiabendazole in ICR mice.

Thiabendazole (TBZ) was tested for teratogenicity using Jcl:ICR mice. TBZ suspended in olive oil was given orally to pregnant mice at different stages of organogenesis. All foetuses were removed from the uterus on day 18 of gestation, and were examined for external and skeletal anomalies. In mice given 700, 1300 or 2400 mg TBZ/kg body weight/day on days 7-15 of gestation, dose-dependent external and skeletal anomalies, especially cleft palate and fusion of vertebrae, were observed. In mice given a single dose of TBZ (2400 mg/kg) on any one of days 6-13, an increased number of malformations was observed. Various types of malformation occurred, especially in the mice treated on day 9. Reduction deformity of limbs was found in mice given TBZ on days 9-12, a change that has not previously been observed to occur spontaneously in normal ICR mice in our laboratory. In order to determine a dose-response relationship, groups of mice were given one of 17 doses of TBZ (30-2400 mg/kg) on day 9 of gestation. The number of litters having foetuses with reduction deformity of limbs and of those having foetuses with skeletal fusion increased in proportion to the dose of TBZ. The regression lines of Y (probit response) on X (log dose) for reduction deformity of limbs and for skeletal fusion were Y = 2.47X - 3.65 and Y = 1.54X + 0.48, respectively. The effective doses (ED1) for the two malformations were 362.0 and 26.4 mg/kg, respectively.

Animals↗
PubMed1984

[Clinical evaluation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) in hepatocellular carcinoma].

1-Hexylcarbamoyl-5-fluorouracil (HCFU) was administered orally to 63 patients with hepatocellular carcinoma (HCC) at a daily dose of 200 to 600 mg. Twenty three of those patients who received HCFU over 4 weeks without any other therapies were studied for its antitumor effect. Eighteen patients were evaluated for tumor size. The results showed a response rate of 16.7% (3/18) based on the criteria of Koyama et al. Patients with minute hepatoma had an especially good response; the response rate being 40% (2/5), or 60% (3/5) including minor response. Tests showed no aggravation of liver function. HCFU was considered to be useful in the treatment of HCC. However, unexpected adverse neurological effects were encountered in 6 patients. They began with slurred speech, bradypragia and gait disturbance, and finally progressed to unconsciousness in 4 out of 6 patients, in which the clinical picture resembled hepatic encephalopathy. Though reversible, these symptoms necessitate immediate withdrawal of HCFU therapy.

Administration, Oral↗
PubMed1984

[Diagnostic value of CT in atlanto-axial dislocation and the choice of treatment].

During the last three years we have experienced 20 cases of atlanto-axial dislocation (AAD) of various types. The series consists of 10 cases of traumatic anterior pure AAD, 2 traumatic anterior AAD with dens fracture, 2 os odontoideum, 1 rheumatic AAD, 1 Jefferson's fracture, and 3 "rotatory dislocation" (1 pure traumatic rotatory dislocation and 2 rotation deformity after Wackenheim). All patients were studied by plain X-ray, tomography, myelography with water soluble contrast media and computed tomography (CT) scanning. All of the operated patients and a part of the non-operated patients were also examined by CT myelography (met. CT) 3 hours after myelography. A special attention was paid to the shape of the spinal cord and the thecal sac at the level of dislocation, in several positions of the head such as hyperextension, neutral position, flexion, lateral bending and right or left rotation. A met. CT could clearly demonstrate that the thecal sac and the spinal cord were compressed by the dens and/or posterior arch of the atlas in traumatic pure anterior AAD. In all cases of ADD with dens fracture or os odontoideum, however, the spinal cord was compressed not by the dens but by the posterior margin of body of the axis. The fractured dens always moved with anterior arch of the atlas. This finding was most clearly documented by met. CT in flexion. In some cases of AAD accompanying rheumatic changes or narrowing of the spinal canal, a posterior decompression with postero-lateral fusion is indicated. A transoral anterior fusion in hyperextended position of C1 and C2 together with the fractured dens, followed by a Halo vest fixation, is the treatment of choice in traumatic AAD with dens fracture and os odontoideum. A posterior C1 and C2 fixation using Urlich's metal plate is also recommended for anterior pure AAD. CT scanning, especially met, CT, is by far the better than the conventional radiologic examinations to determine the indication, approach and mode of operation in AAD.

Adolescent↗
PubMed1984

[Repeated transient paraparesis due to solitary spinal epidural arterio-venous malformation. A case report].

A case of spinal epidural AVM with unusual clinical course was presented. A 28-year-old male had repeated episodes of paraparesis and complete recovery in several hours. Metrizamide myelography revealed the dorsal epidural mass at the level of L2 and L3. Accidental epidurogram during the procedure indicated extradural angioma. Surgical intervention proved solitary spinal epidural AVM. Ninety-nine cases in literature were reviewed. Among them, 14 cases of spinal epidural hematoma were due to ruptured angioma which were verified histologically. Others were unknown causes. Age distribution was discussed. It was suggested that the younger patients in the group of unknown causes might have angiomas. It was emphasized that it should not be overlooked even the insignificant transient symptoms and should schedule the extensive radiological examination in such cases.

Adult↗
PubMed1984

[Spinal intradural arachnoid cyst. Report of five cases and a review of the literature].

Five cases of intradural arachnoid cysts were reported. Two rare cases were in cervical region, other three cases in thoracic region. Clinical and radiological findings were discussed in 67 cases including ours. All our cases with chronic clinical course except one showing spastic para- or tetraparese, sensory disturbance and gait disturbances were not much different to other reported cases in neurological findings. Plain radiography, tomography and intravenous enhanced CT were not effective. In all of the cases spinal CT was performed following metrizamide myelography. Only one cyst failed to detect during metrizamide myelography, but a metrizamide CT revealed the intradural arachnoid cyst even in this case. Vonofakos says that metrizamide myelogram failed to found the arachnoid cysts, however, we could confirm them by performing metrizamide CT about 3 hours after conventional myelography. Moreover reconstruction technique was very effective in ascertaining the shape and the extention of the tumors. Especially it is recommended to do delayed metrizamide CT with ReView technique in order to show the detailed relation between the cyst and the spinal cord. In conclusion, we emphasize the accurate neurological examination, the importance of total myelography and the improvement of fluoroscopic technique in myelography and CT scanning.

Adult↗
PubMed1984

[Surgical treatment of atlanto-axial dislocation. An introduction of two new methods].

In the past fourty-two months we have operatively treated twenty cases of several types of atlanto-axial dislocation (AAD) including an atlanto-axial deformity. A transoral retropharyngeal approach to the anterior arch of the atlas and the body of the axis was performed in two cases of AAD with dens fracture, 2 traumatic pure anterior AAD with relatively narrow spinal canal and 1 os odontoideum. The operative method we have devised is a modification of the transoral micro-surgical odontoid resection. In hyperextended position the fractured dens or os odontoideum comes to the position nearest to the anterior arch of the atlas and a distance between the atlas and the axis almost disappears. In this position a Halo device is installed and the anterior arch of the atlas, the dens and the body of the axis are fixed by an autograft all together. The articular joints between the atlas and the axis are also fixed by small grafts. The "three points fixation" of the atlanto-axial vertebrae may be a better and safer operative technique for selected AADs. Another method for AAD is a posterior atlanto-axial fixation using a metal plate (Urlich Medical Instruments Co., West Germany). This technique is a modification of fixation with wire and methyl methacrylate. A strong point of this new method is that the laminae of the atlas, axis and C3 vertebra in some cases, are fixed not with wire but a plate. The wire is used only to fix the plate on the laminae, so that the wire is not snapped on elastic fatigue.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗