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Biomedical subjects

Y Kagami

Publications and source records attributed to Y Kagami.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Osteonecrosis following radiotherapy in carcinoma of the uterus and pediatric tumors].

Osteonecrosis following radiation therapy in 611 Patients with uterine cancer and 41 patients with pediatric tumor were studied. The 5- and 10-year cumulative bone injury rate after radiation therapy in uterine cancer was 4% and 15.6%, respectedly. Patients who are older than 60 years of age showed high occurrence of radiation bone injury. Otherwise, severe aletrations in shape and complete arrest of growth in irradiated growing bone were observed of even with small doses of 1600 cGy in the lower age level (0-3 age of years) at the time of treatment.

Adolescent↗
PubMed1986

Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I.

We describe five patients with adult T-cell leukemia/lymphoma (ATL) with neither integration of human T-cell leukemia virus type I (HTLV-I) into their leukemia cells nor anti-HTLV-I antibody in their sera. These findings indicate that HTLV-I may not have been involved in leukemogenesis in these patients. The clinicohematological, cytopathological, and immunological features of HTLV-I-negative ATL were exactly the same as those of HTLV-I-associated ATL. Leukemia cells with pleomorphic nuclei, generalized lymphadenopathy, hepatosplenomegaly, skin lesions, hypercalcemia, and elevated lactate dehydrogenase levels, all of which are characteristic features of typical ATL, were also seen in these patients with HTLV-I-negative ATL. Leukemia cells expressed T3, T4, and pan-T-cell antigens in three cases, and T3 and pan-T-cell antigens in two. All five patients had lived in ATL-nonendemic areas. The finding of HTLV-I-negative ATL suggests that factor(s) other than HTLV-I infection may be involved in ATL leukemogenesis.

Adult↗
PubMed1986

[Cisplatin, methotrexate and peplomycin in the treatment of esophageal carcinoma].

Sixteen patients with advanced or recurrent squamous cell carcinoma of the esophagus were treated with cisplatin 80 mg/m2 i.v. on day 1, methotrexate 40 mg/m2 i.v. on day 2 and peplomycin 15 mg/day 24 hours continuous subcutaneous infusion from day 2 to day 5. Each course was repeated every 3 weeks. The overall response rate was 56% (9/16) with no complete response. Of 10 patients with no prior therapy, 7 (70%) showed partial response. Toxic effects were acceptable with no fatalities, but severe nausea and vomiting (56%), transient nephrotoxicity (44%), anemia (44%), thrombocytopenia (31%) and leukocytopenia (19%) occurred. No clinical evidence of pulmonary toxicity was seen. The dose-limiting toxic effect of this regimen was myelosuppression.

Adult↗
PubMed1986

[Results of brachytherapy of tongue cancer].

One hundred thirty-two patients with primary cases of squamous cell carcinoma of the tongue treated at National Sapporo Hospital from 1972 to 1982 were reviewed. Most primary sites were treated with interstitial needle implant with or without external beam irradiation. The local control rate by needle implant for the primary tongue lesions was 85.5%. That for the single plane implant was especially notable at 92.5%. The cumulative five-year survival rate was 92.8% in stage, I, 74% in stage II, 53.2% in stage III, 12.5% in stage IV and 64% overall.

Adult↗
PubMed1986

[Results of several combination modalities for maxillary cancer].

Two hundred forty-six patients with the histologically proved squamous cell carcinoma of the maxillary sinus were treated at the Department of Radiology, National Sapporo Hospital, with various combined modes of surgery, irradiation and chemotherapy. Four combination modalities were used from 1966 to 1983. One hundred sixty-three (66.3%) patients were men and 83 (33.7%) were women. Five-year survival was 41.0% in T2 (16 cases), 22.3% in T3 (176 cases) and 15% in T4 (53 cases). In 72 cases treated since 1978 with tumor reduction as completely as possible, five-year survival was 43.5%. We recommand tumor reduction as complete as is possible and 40-50 Gy irradiation.

Adult↗
PubMed1985

[Combined chemotherapy for head and neck cancer using cisplatin, methotrexate and continuous subcutaneous infusion of peplomycin].

Twenty-one patients with advanced or recurrent squamous cell carcinoma of the head and neck were treated with cisplatin, methotrexate and continuous subcutaneous infusion of peplomycin. The overall response rate was 62% (13/21) with 19% (4/21) complete response. The median duration of partial response was 2 months, while that of complete response was 3 months. Toxic effects were acceptable with no fatalities, but nephrotoxicity (33%), leukocytopenia (24%), thrombocytopenia (29%) and severe nausea and vomiting (76%) occurred. Pulmonary toxicity due to continuous subcutaneous infusion of peplomycin (15 mg/day, 4 days) was not seen.

Adult↗
PubMed1984

[Afterloading interstitial brachytherapy by Ir-192 seed assembly for malignant brain tumor].

We developed and applied interstitial after-loading endocrine therapy as a cancer treatment modality. Between Sept. 1982 and May 1983, 5 patients with malignant brain tumors were treated using the removable after-loading Iridium-192 seed assembly implant technique. 4 of the 5 patients experienced recurrent gliomas after the operation alone or in combination with external post-operative radiotherapy. In 3 patients, local control was achieved and has been maintained for more than 11 months. Our preliminary brachytherapy procedures for the treatment of malignant brain tumors are described.

Adenocarcinoma↗
PubMed1984

[Result of radiotherapy for esophageal cancer--radical radiotherapy combined with intracavitary radium irradiation].

Between 1974 and 1980, 61 primary esophageal squamous cell carcinoma were treated by external irradiation combined with additional intracavitary radium therapy. The esophageal primary control rate was 36% (22/61) and the 5-year survival rate was 24.7%. We believe that external radiation therapy followed by additional intracavitary radium irradiation produces good results.

Adult↗
PubMed1984

[Radiotherapy treatment of esophageal carcinoma--analysis of 5-year survival].

Between 1966-1977, 250 patients with esophageal carcinoma were treated by radiotherapy alone. The 5-year survival rate was 10.4% (12 of 115) in the curative cases. 52 of 5-year survivors, including 40 cases from the literature, were analyzed according to age, sex and the extent, location and type of tumor. 37 patients (71.1%) were between 50 and 69 years of age. There were more female than male survivors. Patients whose esophagograms showed spiral-type tumor had a worse prognosis than other tumor types. 16 of the 52 (30.8%) patients had received intracavitary treatment. We posit that an additional boost dose by intracavitary techniques improves the local control of the primary lesion. Radiation-induced myelitis and carditis were noted in some patients.

Aged↗
PubMed1984

[Multiple primary cancer and radiation-induced cancer of the uterine].

This report is concerned with multiple primary cancers developing in invasive uterine cancer. Second primary tumors were recorded 27 women with a total of 30 non-uterine cancer (exception of radiation-induced cancer). 17 patients of radiation-induced neoplasm were observed (Rectal cancer 4, soft part sarcoma 4, cancer of urinary bladder 3, bone tumor 3, uterine cancer 2 and cancer of Vulva 1). One case is 4 lesions (corpus, sigma, thymoma and stomach), 2 cases are 3 lesions (uterine cervix, stomach and maxillary sinus: uterine cervix, thyroidal gland and radiation-induced soft part sarcoma). Only 5 of these 17 patients were known irradiated dose (50 Gy approximately 55 Gy), however others unknown. The mean latent periods of 17 cases of radiation induced neoplasms are 19.4 years. 16 patients of late second cancers of the cervix appearing from 11 to 36 years (average 19.5 years) after initial radiotherapy were recorded.

Adult↗
PubMed1984

[Study on radiation-induced malignant neoplasms].

Nineteen patients with newly developed malignant neoplasms following radiotherapy are presented. The primary lesions of 6 patients were tuberculous cervical lymphadenitis, the primary lesions of the other 13 patients were malignant neoplasms. The radiation-induced malignant neoplasms of 15 patients were epithelial, only 4 patients were non-epithelial. The prognosis was not good. However, we think that radiation-induced malignant neoplasms are not highly radioresistant and that the benefits of radiotherapy for malignant neoplasms outweigh the risk of radiation-induced malignant neoplasms.

Adenocarcinoma↗
PubMed1983

[Late local recurrence of cervical cancer after initial treatment].

Late local recurrence of cervical cancer more than 10 years after successful initial treatment is very rare. We now present 17 patients with late local recurrence. Only one patient had undergone primary surgery alone; the other 16 patients had received various types of radiotherapy. All 17 patients received radiotherapy as the second treatment. Local control was achieved in 9 patients, 4 of these survived for more than 5 years after the second treatment. Longterm follow-up for more than 10 years is important for the early detection of late local recurrence.

Adult↗