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Biomedical subjects

Y Ide

Publications and source records attributed to Y Ide.

At least 109 records · Page 6Linked to original sources
PubMed1990

Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.

Plasma renin activity, plasma concentrations of angiotensin II (AngII), stable metabolites (6-keto-prostaglandin F1 alpha: 6-keto-PGF1 alpha) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1 alpha were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1 alpha/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1 alpha and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1 alpha/TXB2.

Adult↗
PubMed1990

Study of the internal structure of the infantile zygomatic bone.

External measurements of the zygomatic bone have been reported, but there are no reports on the internal structure. We studied the internal structure of the zygomatic bone and determined the changes in cortical bone width, cortical bone ratio to total cross-sectional area, and trabecular bone width through six periods of tooth growth and development. Zygomatic bone were fixed in resin and sliced, then the cross-sectional specimens were photographed with soft X-rays. The images were analyzed with an image processor. The specimens included the surrounding cortical bone and its internal spongy substance. The cortical bone width, cortical bone ratio, and trabecular bone width increased significantly from the period of deciduous dentition to the first early period of mixed dentition, but leveled off after that. This indicates that in addition to the growth and development of the zygomatic bone itself, its structure is also affected by the forces generated in the maxilla by mastication.

Bone Density↗
PubMed1990

[Brainstem infarcts presented medial longitudinal fasciculus (MLF) syndrome and cerebellar ataxia--report of three cases].

Vascular disorders of the brainstem manifest characteristic neurologic symptoms according to their localization. The medial longitudinal fasciculus (MLF) lies in the paramedian portion of the upper brainstem tegmentum, and the lesion in this fasciculus shows specific abnormality of the eye movement pattern which is known as the MLF syndrome. Although the MLF syndrome was reported frequently to be accompanied by varieties of other neurologic deficits according to the lesion extending into the adjacent structures in the brainstem, the combination of MLF syndrome and cerebellar ataxia has attracted less attention of neurologists. Recently we experienced three cases of cerebellar ataxia arisen simultaneously with MLF syndrome. Magnetic resonance imaging (MRI) tomography or X-ray computed tomography visualized lacunar lesion(s) in the upper brainstem tegmentum in all of three cases. It was obvious that the lesion included the MLF and caused the MLF syndrome in these cases. It was speculated that ventro-caudal extension of the lesion involved the decussation of the superior cerebellar peduncle, and was responsible for the association of cerebellar ataxia with MLF syndrome. According to the recent discussion about the feeding arteries in the brainstem, we decided that the damage of the paramedian branches diverging from the basilar tip resulted in the lacunar lesion(s). The development of diagnostic procedures especially MRI enables the diagnosis of the vascular disorders in the brainstem with considerable accuracy.

Aged↗
PubMed1989

Effects of ALE-36 on gastric secretion, and gastric and duodenal ulcers induced in rats.

We examined the antisecretory and anti-ulcer effects of ALE-36 in rats. ALE-36 (3-30 mg/kg) dose-dependently inhibited gastric acid secretion in pylorus-ligated rats. However, the agent apparently increased the volume of gastric juice, and the Na+ and Cl- ion outputs. These changes were almost completely prevented by pretreatment with indomethacin, suggesting that endogenous prostaglandins in the gastric mucosa mediated the changes. Pretreatment with ALE-36 (3-30 mg/kg) inhibited the development of stress-, aspirin-, and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcers. Repeated administration of ALE-36 significantly accelerated the healing of gastric ulcers induced by thermocautery.

Animals↗
PubMed1989

[Spastic paraplegia in Sjögren's syndrome associated with mixed connective tissue disease (MCTD)--a case report].

A case of spastic paraplegia in Sjögren's syndrome associated with mixed connective tissue disease is reported. In this 49-year-old woman spastic gait and arthralgia developed at the age of 23 years and progressed chronically. On neurologic examination, supranuclear paresis of facial nerve was observed. Deep tendon reflexes were hyperactive in the jaw, upper and lower extremities. Serological tests showed that anti-nuclear, anti-RNP, and anti-SS-A antibodies were positive. Spinal fluid analysis showed that rate of de novo central nervous system (CNS) IgG synthesis was increased, and C3/C4 ratio was elevated. CT scans of the brain showed calcifications at bilateral basal ganglia, dentate nucleus and cerebellar vermis. An electroencephalogram revealed diffuse slowing, and 123I-IMP brain scans revealed decreased cerebral blood flow. MRI of brainstem and cervical cord were normal. These findings suggested that corticospinal tracts upper the brainstem were severely affected, and that there were multifocal latent lesions in the CNS. Mechanisms of the CNS involvement were supposed to be both autoimmune abnormality in the CNS, and vascular impairment.

Central Nervous System Diseases↗
PubMed1989

[A case of cerebellar hemispheric venous malformation presenting crossed cerebello-cerebral diaschisis].

A 49-year-old man was admitted to our hospital complaining of clumsiness in his left arm and leg that had 2 months' history with subacute onset. On examination he showed left sided ataxia but no other neurological deficits. A linear lesion was demonstrated in the left cerebellar hemisphere by X-ray computed tomography and magnetic resonance imaging without apparent hemorrhage and mass effect. Digital subtraction angiography revealed a venous malformation in the left cerebellar hemisphere but carotid arteries were normal. Relative distribution of cerebral blood flow was measured using single-photon-emission-computed tomography with rotating gamma camera and 123I-IMP. Reduced uptake was observed in the right frontal lobe (-15- -30%). However, the asymmetry disappeared 8 months later. The decreased blood flow in the contralateral cerebral cortex may be due to destruction of cerebello-thalamo-cortical pathways.

Angiography, Digital Subtraction↗
PubMed1989

Quantitative and morphological studies of the bones by mathematical morphology--theory and practice of mathematical morphology.

To quantitatively analyze internal bone structures, trabecular bones were quantitatively studied through the application of mathematical morphology. Mathematical morphology considers the shape of the analyze objects and utilizes image processing theory in an approach that is extremely effective on for studying the complex shapes of trabecular bones. This paper describes quantitative studies made of trabecular bone density and width, trabecular specific length per unit area, and trabecular bone orientation.

Bone Density↗
PubMed1989

Quantitative and morphological studies on the trabecular bones in the condyloid processes of the Japanese mandibles. Comparisons between dentulous and edentulous specimens.

Using dentulous and edentulous specimens, mathematical morphology was applied to quantities bone morphology measurements, of the trabecular bones in the condyloid processes, which form the temporomandibular joint and are the center of mandibular motion. There is a tendency for trabecular bone density and width in edentulous specimens to be comparatively lower than for dentulous specimens and a similar decrease in continuity of the trabecular bones. Values for specific length are highest in dentulous specimens, indicating a greater degree of interlocking. A degree of regularity is observed in trabecular bone orientation; in edentulous specimens trabecular bones other than major ones are fewer and thinner.

Adolescent↗
PubMed1989

Quantitative and morphological studies of the trabecular bones in the condyloid processes of the Japanese mandibles; changes due to aging.

The structure of bone changes with advancing age. In order to observe changes in the trabecular bone structure of the mandibular condyloid process and their relationship to age, the mandibular condyloid process and third lumbar vertebra were extracted from cadavers from several age groups, and changes in trabecular bone structure due to age were compared. Comparison of the trabecular bones of the lumbar vertebra and condyloid processes from single cadavers by age revealed a clear reduction in trabecular bone density and width in the lumbar vertebra accompanying advancing age. In the condyloid process in contrast no major changes were observed; it appears that the effects of aging are slight.

Aged↗
PubMed1989

[The sedative effects of a low dose of butorphanol combined with diazepam during spinal-epidural anesthesia (H-type anesthesia)].

The sedative effects of the low dose of butorphanol combined with diazepam during spinal-epidural (H-type) anesthesia were studied in 20 urological or gynecological patients of ASA class I or II. Patients were premedicated with 0.5mg of atropine sulfate and 50mg of hydroxyzine hydrochloride 1 hour before the operation. Spinal anesthesia was performed with 2.4 ml of 0.3% dibucaine or 2.5 ml of 3% lidocaine and if necessary 1-2% mepivacaine was administered via the catheter for maintenance of the epidural anesthesia. Butorphanol 0.5 mg and diazepam 5 mg were administered intravenously after the establishment of spinal anesthesia. We observed the condition of sedative effects, the changes in blood pressure, heart rate and respiratory rate, before the administration of butorphanol, 2 and 5 minutes after the administration of the drug and then every 5 minutes until the recovery was noticed. We found that the sedative effects of butorphanol combined with diazepam were clinically sufficient. Patients were sleeping for 40 minutes and then drowsy for 30 minutes with sufficient sedation. There was no complication except slight respiratory suppression. Our results suggest that the butorphanol combined with diazepam is a useful method for the sedation during spinal-epidural anesthesia.

Adult↗
PubMed1988

[Postoperative pulmonary embolism in neurosurgical practice: report of two cases].

Pulmonary embolism following postoperative deep venous thrombosis is a very serious complication with a high mortality rate. Though this disorder has been thought to be rare in Japanese, its occurrence seems to be increasing recently because of changes in eating habits, increase of average age and the frequent practice of venous catheterization. Two cases of the pulmonary embolism following deep venous thrombosis after surgery are reported, and possible causes of the deep venous thrombosis are discussed. Case 1: A 48 year-old obese female was operated on for a posterior fossa dural arteriovenous malformation. On the 4th postoperative day, she developed a pain and swelling in the left leg and low back pain. On the 18th postoperative day, she fell into a state of shock following the sudden onset of a severe back pain and respiratory distress. After diagnosis of the pulmonary embolism, she was immediately treated with urokinase, warfarin and aspirin. Her obesity was considered to be one of the risk factors of the postoperative deep venous thrombosis. Case 2: A 62 year-old female with a ruptured cerebral aneurysm could not get out of bed because of postoperative mental disturbance. A central venous pressure catheter was inserted into the right femoral vein for two weeks postoperatively. One month after surgery, she complained of swelling and a dull pain in the right leg without cardiorespiratory symptoms. Lung perfusion scintigraphy showed asymptomatic pulmonary embolism. She was treated immediately. Both long bed rest and femoral venous catheterization were considered as risk factors possibly leading to deep venous thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain↗
PubMed1987

[A case of iatrogenic traumatic intracranial aneurysm].

A case of traumatic aneurysm due to an arterial injury during removal of a tuberculum sellae meningioma is reported. A 43-year-old man had undergone craniotomy for removal of the tumor. It was very hard with many feeders from bilateral anterior cerebral arteries (ACA), so the resection between the left ACA and the tumor was difficult. A small artery was accidentally pulled out from the left ACA and bleeding occurred from the small artery in the artery. The ACA was trapped temporarily with two clips and was coated using Oxycell and Biobond. The bleeding was stopped by this procedure and the blood reflowed. This tumor was removed totally, but postoperative CT scan showed an enhancing small lesion in the anterior part of the left basal ganglia 10 days after operation. The angiograms performed next day revealed a fusiform aneurysm of the left proximal ACA near the anterior communicating artery. The skull was reopened to treat the aneurysm. The aneurysm arising from just a bleeding point in the previous operation was oval in shape without neck, so it was trapped by two small aneurysm clips and resected. The patient's condition was uneventful after the second operation. Pathological diagnosis of the aneurysm was confirmed a false aneurysm. Iatrogenic traumatic aneurysms caused by neurosurgical procedure has been reported in 29 cases. Eighteen cases showed bleeding from injured artery during surgery and a half of them showed rupture from the aneurysm within one month after operation. Such doubtful cases of traumatic aneurysm should be diagnosed by angiography and operated as early as possible.

Adult↗
PubMed1985

Rudimentary polydactyly: report of five cases.

Rudimentary polydactyly was found in five patients. Surgical exploration of the papules revealed findings that have not been previously published. A cord-like structure arises from the bottom of the papule, with its proximal portion joining the neurovascular bundle of the digit. Histologic examination of the cord showed strong similarity to the neurovascular bundle of a finger. From these findings, we assume that rudimentary polydactyly may represent the amputation stump of pedunculated fingers.

Child↗
PubMed1984

[Report of a family with cancer family syndrome].

A report of multiple primary early duodenal cancer and ileocecal cancer with cancer family syndrome is presented. Analysis of 65 individuals of this family showed 7 large bowel cancers, 1 lung cancer and cancer of the uterine cervix. The characteristics of this family including increased occurrence of adenocarcinoma, especially large bowel cancer, 3 multiple primary malignant neoplasms, early age of onset of cancer and suspicion of autosomal dominant inheritance, satisfy the criteria for the cancer family syndrome. We recommend screening the individuals in this family for early signs of cancer.

Adenocarcinoma↗