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Y Hosoya

Publications and source records attributed to Y Hosoya.

At least 145 records · Page 8Linked to original sources
PubMed1987

The topographical organization of neurons in the dorsal hypothalamic area that project to the spinal cord or to the nucleus raphé pallidus in the rat.

The present study was undertaken using retrograde labeling techniques to clarify whether the neurons in the dorsal hypothalamic area (DHA) that project to the spinal cord are the same as those that project to the nucleus raphé pallidus (NRP). Following an injection of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) in the NRP many labeled small neurons (6-13 X 9-22 microns) with an oval shape were found in the ventromedial part of the DHA. At the level of the dorsomedial hypothalamic nucleus, they formed a distinct and compact cell cluster. Labeled neurons, which were large in size (9-22 X 11-36 microns) with oval and triangular shapes, were found mainly in the dorsolateral part of the DHA after injections of horseradish peroxidase (HRP) in the spinal cord. In a double-labeling experiment, Fast Blue or True Blue, and Nuclear Yellow were injected in the NRP and in the spinal cord, respectively. A large number of blue-fluorescent neurons were located mostly in the ventromedial part of the DHA, while yellow-fluorescent ones were found in the dorsolateral part of the DHA. However, no double-labeled neurons were found in the DHA. These results show that the neurons of the DHA projecting to the NRP are essentially different from those which project to the spinal cord.

Animals↗
PubMed1987

[Tegafur and 5-FU concentrations in cancerous and normal tissues in nude mice after oral administration of UFT].

Tegafur and 5-fluorouracil (5-FU) concentrations in blood, tumor, kidney and liver tissues of nude mice implanted with human urogenital carcinoma were determined after oral administration of UFT. The results were as follows: The concentration of tegafur in serum and other tissues rose quickly reading to the peak levels by 15 minutes after administration of UFT, then decreasing gradually. The concentration of 5-FU in serum, liver and kidney showed similar changes, but concentration of tumor tissues were maintained high until 2 hours after administration. These results suggest that coadministration of uracil with tegafur increase the antitumor activity of tegafur.

Animals↗
PubMed1985

Hypothalamic projections to the ventral medulla oblongata in the rat, with special reference to the nucleus raphe pallidus: a study using autoradiographic and HRP techniques.

Hypothalamic descending projections to the medullary ventral surface were studied autoradiographically in the rat. A small amount of [3H]leucine was injected unilaterally into various parts of the hypothalamus by air pressure. Abundant and characteristic terminal labelings were observed bilaterally in the nucleus raphe pallidus, the ventral surface of the pyramidal tract and the nucleus interfascicularis hypoglossi, after injections into the dorsal posterior hypothalamic area caudal to the paraventricular hypothalamic nucleus. Conspicuous, but less numerous labelings were observed in the nucleus raphe obscurus and the ipsilateral raphe magnus. After an injection of [3H]leucine into the hypothalamus and injections of horseradish peroxidase (HRP) into the spinal cord in the same animal, silver grains were densely distributed around HRP-labeled neurons in the nucleus raphe pallidus including the nucleus interfascicularis hypoglossi. The present results suggest that the dorsal posterior hypothalamic area projects directly to the spinal-projecting neurons of the nucleus raphe pallidus.

Animals↗