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Biomedical subjects

Y Fujimoto

Publications and source records attributed to Y Fujimoto.

At least 577 records · Page 32Linked to original sources
PubMed1983

[Treatment of prostatic cancer by intramuscular administration and intratumor injection of peplomycin].

Peplomycin, a new derivative of Bleomycin, was evaluated clinically for treatment of prostate cancer patients. Peplomycin was injected intramuscularly, 5 or 10 mg every other day, to 8 patients with prostate cancer. Total dose ranged from 30 to 200 mg. According to Karnofsky's criteria, only one case was I-B, other cases were in group 0. Pulmonary fibrosis, one of the major side effects of this drug, was experienced in 2 cases. This anticancer agent was injected directly into the prostate, 20 mg once a week for 5 weeks, to 2 patients who were refractory to estrogen treatment and had lower urinary obstruction for relief of local symptoms. One case was I-A, and the other was I-B. No severe side effect was observed. Serum concentration of Peplomycin after administration was measured by a bioassay. Serum levels of Peplomycin after a local injection of 20 mg and after one intravenous shot of 10 mg were almost equal.

Aged↗
PubMed1983

Experimental transplacental transmission of canine herpesvirus in pregnant bitches during the second trimester of gestation.

The effects of canine herpesvirus (CHV) on fetuses were studied after IV inoculation of pregnant bitches in the 2nd trimester of gestation. Cesarean sections were performed on 2 bitches that were inoculated with CHV on the estimated 30th day of gestation. Bitch M-1 had 2 mummified fetuses and bitch M-2 had 4 mummified and 2 dead fetuses and 3 live-born pups. Infection by CHV was confirmed histopathologically by the presence of focal areas of necrosis associated with intranuclear inclusion bodies in heart muscle sections of 1 dead fetus; CHV was not recovered from other organs. Abortion occurred between the 2nd and 3rd week after inoculation of another pregnant bitch inoculated with CHV on the estimated 30th day of gestation. Two bitches inoculated with CHV on the estimated 40th day of gestation gave birth prematurely to 10 pups. The detection of characteristic herpesviral lesions in various organs and the reisolation of CHV from the liver, spleen, kidneys, and lungs of premature pups indicated CHV infection. Transplacental infection of fetal pups by CHV resulted in their death and subsequent mummification. It appears that abortion and premature birth also may occur in pregnant bitches infected during the 2nd trimester of gestation.

Abortion, Veterinary↗
PubMed1983

[T-cell bearing IgG-Fc receptor in patients with bladder cancer].

The T-cell bearing Fc receptor (IgG-FcR+ T cell) has been considered as a suppressor or a part of the killer cell, as determined by its function. The population of IgG-FcR+ T cells was determined by Moretta 's method in patients with urinary bladder cancer, urological benign diseases and in normal subjects. The population of IgG-FcR+ T cells in the peripheral lymphocytes of 16 patients with urinary bladder cancer was 20.5 +/- 10.1%, that of 7 patients with urological benign diseases was 9.5 +/- 3.2%, and that of 8 normal subjects was 9.0 +/- 2.1. The population of IgG-FcR+ T cells in the peripheral lymphocytes patients with high stage bladder cancer was significantly higher than that of patients with low stage cancer. In low stage bladder cancer cases, the population of IgG-FcR+ T cells was decreased to the normal range at three weeks after removal of the tumor. But in high stage bladder cancer cases, it was not changed at 3 weeks.

Adult↗
PubMed1983

[The study of infiltrating lymphocytes in the tissues of bladder carcinoma].

Using 121 patients with bladder cancer operated on at our institutes, the relationship between lymphocyte infiltration and grading, staging or patients' prognosis was studied for evaluating regional immunocompetence in bladder cancer. There was no correlation between number of infiltrating lymphocytes and tumor grading or staging. However, the patients with high grade or advanced stage showed high recurrence rate and mortality. The same tendency was observed in patients whose tumor had few infiltrating lymphocytes. A lymphocyte subset was detected in both peripheral blood and tumor extracts in 15 cases of bladder cancer. Compared with the normal controls, T cell percent was lower and T gamma cell ratio was higher in peripheral blood of bladder cancer patients. T cell percent was almost equal in peripheral blood and in cancer tissue, but the T gamma cell ratio in the cancer patients was much higher than that in blood. In the tumor tissues, high T cell and lower T gamma cell percentages were observed at basal areas than those at superficial portions. These results suggest that infiltrating lymphocytes may take part in the host response to the tumor in bladder cancer. Classification of these lymphocytes based upon function will be necessary for further study.

Adenocarcinoma↗
PubMed1983

[A case of a scrotal hemo-lymphangioma].

A nineteen-year-old man with a painless tumor in the right scrotal area was seen at our Department. The scrotal mass had been noticed from his childhood. The tumor was 8.2 X 5.2 X 5.0 cm weighed 47.3 g. Histological examination revealed hemo-lymphangioma.

Adult↗