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Y Fujimoto

Publications and source records attributed to Y Fujimoto.

At least 559 records · Page 31Linked to original sources
PubMed1984

[A case of perirenal encysted hematoma secondary to renal cell adenocarcinoma].

Herein we report a case of perirenal encysted hematoma secondary to renal cell adenocarcinoma. A 57-year-old woman was hospitalized because of a palpable mass in the left flank. She had had an episode of left flank pain. X-ray studies demonstrated a tumor in the left kidney and a large cystic mass beneath the left kidney. The cyst was excised by nephrectomy. Histological examination of the large cyst revealed perirenal encysted hematoma secondary to renal cell adenocarcinoma. Six months postoperatively, she is now free from left lumbar pain, and alive with lung and liver metastasis.

Carcinoma, Renal Cell↗
PubMed1984

[A case of giant prostate cancer].

A 67-year-old patient with stage C giant prostate cancer was treated with a combination of endocrine administration and chemotherapy. After administration of diethylstilbestrol diphosphate (250 mg/D, 16 days), bilateral orchiectomy and subsequent CDDP administration (30 mg/D X 5 days, e. 3 weeks, 4 courses), the primary tumor was reduced by about 90%. Clinical response was evaluated as partial response. Serum acid phosphatase activity, prostatic acid phosphatase, prostate antigen and nuclear DNA histogram served as useful tumor markers and changed in parallel to clinical course.

Adenocarcinoma↗
PubMed1983

Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai.

Three of four natural compounds, which are caffeic acid, eupatilin and 4'-demethyleupatilin, isolated from Chinese plant, Artemisia rubripes Nakai selectively inhibited 5-lipoxygenase of cultured mastocytoma cells. Half-inhibition doses (ID50) for caffeic acid, eupatilin and 4'-demethyleupatilin were 3.7, 14 and 18 X 10(-6) M, respectively. The inhibition by caffeic acid was non-competitive types. Prostaglandin synthase activities were little inhibited by eupatilin and 4'-demethyleupatilin, but rather stimulated by caffeic acid. The formation of leukotriene C4 and D4 by mast tumor cells was almost completely suppressed by these compounds at 10(-4) M.

Animals↗
PubMed1983

The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices.

Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.

Animals↗
PubMed1983

Evaluation of serum prostate-specific antigen in urologic cancers.

Serum prostate-specific antigen (PA), a new tumor marker of prostate cancer, was evaluated with an eznyme immunoassay (EIA) in various urologic cancer patients and benign prostatic diseases in Japanese. Sera of prostate cancer patients before treatment (n = 27) revealed a range of PA concentrations from 0.12-23 ng/ml with a mean (+/- SD) of 5.78 +/- 6.85 ng/ml, while that of patients with benign prostatic hypertrophy (BPH) (n = 27) showed from less than 0.10 to 2.6 ng/ml with 0.84 +/- 0.81 ng/ml (mean +/- SD). The mean serum PA levels in nonprostatic cancers were calculated as follows: bladder cancer (n - 21), 0.77 +/- 0.55 ng/ml; renal pelvis or ureteral cancer (n = 6), 0.46 +/- 0.47 ng/ml; renal adenocarcinoma (n equal to 6), 1.07 +/- 0.77 ng/ml; other urologic cancers (n = 6), 0.55 +/- 0.52 ng/ml. Serum PA ranged from less than 0.10 to 1.1 ng/ml in patients with prostatitis (n = 5). A significant statistical difference in serum PA levels between prostate cancer and other groups was recognized. These results suggested that an elevation of serum PA value was highly specific to prostate cancer in urological malignancies. The evaluation of serum PA may be of great value in the detection of prostate cancer.

Adenocarcinoma↗
PubMed1983

RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat.

The immune response to bovine or pork insulin (BI or PI, respectively) was studied in the rat using the in vitro insulin-induced lymphocyte-proliferation assay. Results indicated that 11 inbred rat strains were divided into categories of high and low responders. Two high responders, SDJ (RT1u) and BN(RT1n) inbred rat strains, appeared to recognize different antigenic determinant(s) on the insulin molecule. The results of linkage and segregation analyses in F1, F2, backcross, and partially congenic rats showed that the Ir gene (Ir-BI), which encodes the high responsiveness in the SDJ rats, is inherited associated with RT1u, whereas the immune suppression gene (Is-BI), which encodes the low responsiveness in the WKA(RT1k) rats, is inherited together with RT1k. The Is-BI is the first major histocompatibility complex (MHC)-linked Is gene reported in the rat. The LEJ(RT1-AuBb) inbred rat strain showed a low response to BI, indicating that Ir-BI is closer to RT1-B/RT1-D region than to RT1-A.

Animals↗
PubMed1983

Human medullary carcinoma of the thyroid in tissue culture.

Medullary thyroid carcinomas (MCT) were obtained from patients with Sipple's syndrome or non-hereditary MCT. Cultures of enzymatically dissociated cells showed that MCT cells were mostly free-floating cells of epithelial characters. These MCT cells preserved the ability to secrete calcitonin for a long period of in vitro maintenance. However, the MCT cells under the usual culture conditions were filled with numerous cytoplasmic granules and appeared to be extremely fragile. When MCT cells were cultured in a low-calcium medium, such granules were not observed. In addition, MCT cells in the low-calcium medium increased the amount of calcitonin in response to added calcium and tetragastrin. Therefore, the culture of MCT cells in the low-calcium medium appeared to be useful for studies about the biochemical and physiological characters of human MCT cells in vitro.

Calcitonin↗
PubMed1983

Ultrastructural study of Ni3S2-induced tumors in rats.

An ultrastructural study was conducted on a total of 24 tumors selected from 70 tumors induced by intramuscular injection of Ni3S2 in Fischer and Hooded rats. Well differentiated rhabdomyosarcomas were predominantly composed of strap-like cells containing numerous myofilaments occasionally forming S-line-like structures, whereas poorly differentiated rhabdomyosarcomas were made up mainly of round or oval cells with abundant cytoplasm. Embryonal rhabdomyosarcomas contained cells resembling the mast cells in myxomatous areas as well as spindle-shaped myoblast-like cells. Mesenchymal tumors exhibited morphological characteristics of the lymphoid cells. The tumor cells from leiomyosarcoma-like tumors showed myoblast-like appearance. Tumors diagnosed as fibrosarcoma-like tumors at the light microscopic level demonstrated the ultrastructural characteristics of fibrosarcomas. The possibility of a multicentric origin of the tumor cells in Ni3S2-induced tumors has been discussed.

Animals↗
PubMed1983

Immunochemical evidence for multiple beta units of the class II molecule in the rat.

The RT1-B/D region-associated antigens which were serologically defined in the previous study (Ohhashi et al., 1981), were partially purified from membranes of a rat B cell leukaemia, KNL-14. Sequential immunoprecipitation test, with the partially purified 125I-B/Dak preparation using four different rat alloantisera, including a monoclonal antibody, disclosed three distinctive populations of beta units of the class II molecules. Highly purified beta units of three discriminable class II molecules were shown to have different structural properties in terms of molecular weights and of electrophoretic profiles on the isoelectric focusing. The beta units shifted to a position of higher molecular weight on SDS-PAGE under reducing condition, thus suggesting to carry intradisulfide bonds. Furthermore, the highly purified beta units cross-reacted with murine anti-Ia sera. The rebinding test revealed that at least two discriminable species of beta units cross-react with anti-I-Ak monoclonal antibody, whereas beta units purified by binding with the 1E4 monoclonal antibody cross-reacted with anti-I-Ab and/or anti-I-Ad antiserum. On the basis of structural and antigenic properties, we have postulated that the rat class II region can be divided into at least three subregions, each containing a locus which encodes a distinctive beta unit of the class II molecule.

Animals↗
PubMed1983

Studies on the Indonesian Antiaris toxicaria sap.

The present research is on a milky sap obtained from the Antiaris toxicaria tree (Moraceae) which is called Upas or Ipoh in Indonesia. The crude sap was administered to anesthetized rats, and changes in electrocardiogram (ECG) and systemic blood pressure was observed. Biologically and pharmacologically active components were extracted from the crude sap by means of water-acetone solution. Based on the strength of chemical qualitative detection tests of the sap extract (SE), cardiac glycosides are supposed to be the main components. The SE inhibited the Na+-, K+-ATPase (EC 3.6.1.3) which was partially purified from guinea pig heart muscle. When the SE and, concurrently, authentic ouabain were applied to isolated frog heart muscles, the fall of twitch tension was observed after the increased tension on mechanograms. These facts suggest that the main components of the milky sap are cardiac glycosides, and glycosides affect Na+, K+-ATPase activity of muscle membrane and heart muscle contraction.

Animals↗