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Biomedical subjects

Y Copelovici

Publications and source records attributed to Y Copelovici.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Studies of human cytomegalovirus complement-fixing antigen.

Various techniques are described for the preparation of complement-fixing(CF) antigen from the cell-associated phase of two strains of human cytomegalovirus. Preliminary results regarding the preparation of CF antigen from extracellular virus are also presented. The qualities and shortcomings of each of the biological preparations obtained by the different procedures are outlined.

Antigens, Viral↗
PubMedDate not supplied

Trends in the rapid diagnosis of viral infections.

The authors discuss different aspects of the rapid diagnosis of viral infections: its necessity, its characteristics, the recent advances having allowed the development of modern techniques. Further, the main categories of procedures used in rapid viral diagnosis are reviewed: 1) electron microscopy, 2) immunofluorescence and immunoperoxidase techniques; 3) solid-phase systems with labelled reactants; 4) agglutination with supporting particles; 5) counterimmunoelectrophoresis; 6) rapid/early serological diagnosis. Data are discussed as regards the possibility of the large-scale application of rapid viral diagnosis procedures in Romania.

Agglutination Tests↗
PubMedDate not supplied

Evaluation of the prematurity risk on the ground of severity scores reflecting the action of different factors, maternal virus infection included.

A mathematical methodology is suggested which allows the a priori calculation of the risk of premature delivery, by a formula relying on the scores attributed to different specific risk factors (maternal virus infections included). The scores are estimated either directly, or starting from the scores of nonspecific factors. The statistical significance of the different scores, correlations and formulas is analyzed.

Adult↗
PubMedDate not supplied

Study of antibodies against viruses, chlamydiae, rickettsiae and Mycoplasma pneumoniae in children with respiratory diseases.

Seroconversion to different viral, chlamydial, rickettsial and mycoplasma antigens was followed up in 134 children aged 0-6 years, hospitalized with different respiratory diseases. Parainfluenza viruses type 1, 2 and 3 and adenoviruses appeared to be involved in the etiology of most of the cases; respiratory syncytial virus was often found to play a role in pneumonia/bronchopneumonia and in "influenza-like illness", while chlamydiae and M. pneumoniae could be incriminated in cases of "influenza-like illness", as well as in the other categories of respiratory disease. Mixed infections with the agents studied could be detected.

Antibodies, Bacterial↗
PubMedDate not supplied

Statistical studies on the epidemiology of human congenital malformations. Implications of maternal virus infections.

Prospective and retrospective statistical studies were performed in 1,000 cases of congenital malformations. The incidences and severity of the different types of malformations were correlated with the risk and protection factors having acted on the pregnant woman. The correlation coefficients were higher in the case of specific risk factors, among which special attention was paid to maternal virus infections. The possibility is discussed of developing a programme for the individual protection of high-risk cases, implying the compensation of the exposure to risk factors by the application of adequate protection factors, according to the calculated scores.

Congenital Abnormalities↗
PubMedDate not supplied

Stochastic model of the evolution of viral hepatitis morbidity.

Starting from the elementary epidemiological processes, the authors develop an evolution equation of the function generating the probability distribution of the number of viral hepatitis (VH) patients and susceptible subjects. Evolution equations for moments of order 1 and 2 - resulting from the equation of the generating function-are also discussed on the ground of certain simplifying hypotheses. The formulae are applied to the analysis of VH morbidity evolution in several children communities. The data on the evolution of the different moments and of the probability distributions are used from the specification of epidemiological transmissibility and susceptibility parameters.

Epidemiologic Methods↗
PubMedDate not supplied

Investigations concerning the action of serveral chemical and biological agents on HBsAg.

Native and purified HBsAg preparations were subjected in vitro to the action of cetylpyridinium bromide (Bromocet), hibitan-chlorhexidine (Hibiscrub), chloramine B and propolis extract, at different concentrations and for various time intervals. The effect of these agents on the serological reactivity of HBsAg was tested by electroimmunodiffusion (EID) and radioimmunoassay (RIA). Chloramine B and the propolis extract had a significant inhibitory effect-ascertained by both EID and RIA - on purified HBsAg, but not on the native preparation. The inhibition exerted by Bromocet and Hibiscrub indicated by EID results was not confirmed by RIA.

Cetylpyridinium↗
PubMedDate not supplied

Prevalence of antiviral antibodies in workers handling wastewater and sludge.

Serological investigations were performed between 1977-1978 with 972 serum samples from 243 subjects having either direct (group A) or sporadic (group B) occupational contact with wastewater or sludge. the control group (C) was represented by 100 persons having no contact with such material. The sera were tested against influenza, parainfluenza, adeno-, herpes, coronavirus, rickettsial and chlamydial antigens, as well as for the presence of HBsAg and anti-HBs. Statistically significant differences between group A and groups B and C were found as regards the prevalence of antibodies to adenovirus and parainfluenza virus type 1 antigens.

Antibodies, Viral↗
PubMedDate not supplied

The evidence of circulation of some viruses in a great town of Romania during the first half of 1992.

Complex serological survey performed in the town B. during the first half of 1992 emphasized an active circulation of some respiratory viruses, especially of parainfluenza type 3 and 1, influenza subtypes A(H3N2) and A(H1N1), adeno and syncytial respiratory as well as of Mycoplasma pneumoniae. Less important was the frequence of antibodies against Chlamydia psittaci, East equine, West Nile and tick-borne encephalitis as well as parainfluenza type 2 and influenza type B viruses.

Adolescent↗