[Observation, by means of immunofluorescence, of the appearance and evolution of vaccinal antigen in cell cultures].
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Biomedical subjects
Publications and source records attributed to Y Copelovici.
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The internal connections between the variables defined by the data obtained from viral hepatitis (VH) report records completed ih a Romanian county durihg 1973 are analysed. The mathematical model for linear factorial analysis allowed a simultaneous processing of all variables and the distinction of representative factors. The conclusions of the study suggest new possible approaches by the introduction of supplementary questions in the VH report records.
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By a qualitative analysis of the solutions of the mathematical model equations (describing the morbidity and susceptibility evolution in a viral epidemics), approximate formulae for the extreme values of the variables and for the duration of the main phases of a multiannual cycle are deduced. These formulae were validated by numerical simulation of the solutions, leading to the exact values of the mentioned essential characteristics of the diseases propagation.
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A study was worked out on the etiopathogenic relations and a more exact evaluation of the incidence of some agents: viruses, chlamydiae, mycoplasmas and rickettsiae, in the respiratory diseases of 0- to 12-month-old children. Serological analysis and immunofluorescence examination of pharyngeal cells were done. Results showed that parainfluenzae and respiratory syncytial viruses, chlamydiae, rickettsiae and mycoplasmas had an important part in the outbreak and maintaining of severe respiratory diseases in the 0- to 12-month-old children population.
A group of 55 patients with insulin-dependent diabetes mellitus, aged from 8 to 40 years, was followed and compared to a group of controls, in view of detecting a possible relation between the presence of inframicrobial agents and diabetes pathogenesis. The investigations revealed, in patients, significantly higher positivity rate of antibodies against mumps (27% versus 16.3% in controls), parainfluenza type 1 (45.4% versus 29.1%) and Epstein-Barr (54.5% versus 10.9%) viruses, and Mycoplasma pneumoniae (43.6 versus 18.2%).
This work presents the results of a study on some viral, chlamydial, rickettsial and mycoplasmal agents incidence and their role on several gynecological ailments: vulvovaginitis, cervicitis, cervicovaginitis. The presence of some viral, chlamydial, rickettsial and mycoplasmal antigens in the vaginal secretion was investigated by immunofluorescence technique, isolation on selective media for Mycoplasma, and MGG staining in a group of 60 women with gynecopathies (group A) and in a control group (also 60 clinically healthy women) (group B). This study pointed out to higher incidence of chlamydial and mycoplasma antigens as well as of parainfluenza virus types I and III, adenovirus and herpes virus type II in group A. The serological screening revealed significant differences between the specific antibodies to antigens found in vaginal secretions to prove the presence of an immunological response on the same category of subjects.
Investigations were conducted on groups of subjects hospitalized in surgery services with a clinical diagnosis of acute or chronic appendicitis, to detect the presence of inframicrobial antibodies and antigens, as well as that of the C reactive protein in these patients as compared with a control group. The results of serological tests and of the examination of pieces of appendix are also presented. The obtained data are used as arguments for the theory of an inframicrobial infection part in some acute and chronic forms of appendicitis.
The report presents a statistical synthesis (a microcomputer Junior was used) concerning the incidence of various acute infections of the upper respiratory tract (AIURT), the stages of their evolution, the distribution of cases among the population groups, the seasonal incidence and the values of epidemiologic parameters. We used clinical and epidemiologic data on AIURT of viral etiology (especially influenza). The structure of a data base on the epidemiology of AIURT of viral etiology is also presented.
Essential peculiarities of the kinetics of the morbidity evolution of most frequent virus diseases were explained using a determinant mathematical model. The main epidemiological parameters for the whole territory of the S.R. of Romania and of Sibiu County were evaluated for the 1967-1986 period.
Investigations conducted on subjects with epidemic parotitis serologically confirmed (hemagglutination inhibition) allowed the detection of amounts of C reactive protein (Crp) higher than the normal level in 34% of the serum samples collected during the first twelve days of illness. After that, the Crp gradually decreased. The results showed that Crp is present in more than 40% of the subjects with uncomplicated mumps and in 55 to 75% of the cases with such complications as meningitis or orchitis. In most of the subjects, the Crp was found only in the first sample, but not in the second. Nevertheless, high amounts were found later, simultaneously with anti-mumps antibodies.
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