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Biomedical subjects

Y Carcassonne

Publications and source records attributed to Y Carcassonne.

At least 145 records · Page 8Linked to original sources
PubMed1979

[The association of a myeloma and Paget's disease (author's transl)].

The coexistence of a myeloma and Paget's disease in the same patient is only rarely reported in the published literature. The frequency of such an association was studied when reviewing 3 cases observed by the authors: an IgG myeloma discovered following a spasmodic paraplegia in a patient with Paget's disease; a patient who was found to have a myeloma, a polynuclear neutrophil leukemia, and Paget's disease; and an IgG myeloma in a patient with probable localized Paget's disease. The incidence of the association myeloma-Paget's disease is much lower than that of sarcomatous degeneration. It should be determined precisely, however, as our future conception of the reciprocal relationship between the two diseases is greatly dependent on this information. Furthermore, the very few cases reported, and their lack of homogenicity, are the reasons why most authors feel that the association of myeloma and Paget's disease as pure coincidence. Many new cases, however, have been recently reported. The problem of the significance of the association of Paget's disease and macroglobulinemia or other monoclonal gammapathies has still to be solved.

Aged↗
PubMed1978

[The contribution of whole body scanning in the exploration of haematological diseases. Preliminary study of 100 patients (author's transl)].

One hundred patients suffering from haematological diseases were explored by whole body scanning. The diagnosis was a lymphoma in the majority of cases (77). Analytical study of the images obtained was made on the basis of the various sections made systematically in the protocol of the study. Scanning proved to be of particular value in the thorax in the study of pleural and juxta-pleural lesions. In the abdomen, study of the liver, spleen and retro-peritoneal space benefited from the use of this means of investigation. Supra-mesocolic sections were felt to be of the greatest value, making it possible to demonstrate lymphadenopathies not revealed by lymphography. Scanning, perfectly harmless, provides a valuable contribution in determining the extent of lymphoma spread and facilitates the therapeutic surveillance of haematological disorders.

Adolescent↗
PubMed1978

Histamine release reaction of basophils in chronic granulocytic leukaemia. Induction by heterologous anti-immunoglobulin E, concanavaline A, and phytohaemagglutinin; effect of heavy water.

Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretory process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that of immunological activation. Heavy water is not a histamine releasing inducer but it increases histamine release of the cells. We studied the histamine release reaction of leukaemic basophils in 10 patients and found a physiological response such as that previously reported with normal human basophils.

Antibodies, Anti-Idiotypic↗
PubMed1978

[Solitary secreting plasmocytoma in a femoral localization in a young man (author's transl)].

A pathological fracture in 20-year-old man led to the discovery of a right femoral plasmocytoma. Immunoelectrophoresis revealed the existence of a monoclonal Kappa IgG. After tumour reduction by radiotherapy and chemotherapy, surgical excision was possible with the insertion of a reconstructive prosthesus. Functional recovery was complete. The dysglobulinaemia completely disappeared and, with a two year follow-up, no dissemination of the plasmocytoma has been found.

Adult↗
PubMed1978

[Endocranial complications in hemopathies. Merits of computerized axial tomography (CAT) (author's transl)].

On the basis of 88 patients examined with CAT, the writers consider the merits of this method of investigation in a study of endocranial complications in blood diseases. Interest in CAT is related in great part to its innoccuousness (making it possible to extend its application to often seriously ill patients) and the precision of the images which are obtained. This precision makes it possible to visualize lesions which at times can not be detected with other methods. A great part of present knowledge on endocranial complications in blood diseases is based on autopsy findings. With CAT, there is definitely the possibility of performing anatomical studies during the patient's lifetime, thus providing a better understanding of the characteristics and frequency of these complications. This is already made clear by this preliminary study, particularly in the area of acute leukemia and Hodgkin's disease.

Adolescent↗
PubMed1977

A surface antigen associated with Hodgkin's disease: brief communication.

We used an indirect immunofluorescence technique to detect a surface antigen that may be associated with Hodgkin's disease (HD). A heteroantiserum raised in a rabbit given an injection of cells obtained from an HD lymph node (Stage I, classification of Lukes and Butler) allowed us to detect an antigen on the surfaces of HD-derived cells in 25 of 27 instances. Benign and malignant non-HD-type lesions (both lymph node and spleen) did not have this antigen. The nature of this antigen and the type of cells bearing it are unknown.

Antigens, Neoplasm↗
PubMed1977

The use of hybrid cells in immunotherapy.

HARRIS et. al. isolated somatic hybrid cells (A9/SEWA) between polyoma-induced tumor and mouse fibroblast cell lines. Although these hybrid cells were no longer tumorigenic, we found that their immunogenicity was conserved. It therefore seemed to us that these antigenic, non transplantable, living cells would be an ideal tool for immunotherapy experiments. In our first experiments we assessed the immunoprotection afforded by A9/SEWA cells in both the SEWA tumor/A.SW mouse and C3HPy/C3H mouse systems. However, the efficiency of immunization with hybrid cells is dependent on the stability of the cells, especially in respect to the expression of the TATA. So we also tried to evaluate the immunogenicity as a function of the number of subcultures undergone by the hybrid line. In both systems, the immunogenicity was very good in the early subcultures but, in the C3HPy tumor/C3H mouse system, a loss of immunogenicity was observed as the number of subcultures increased. Thus any clinical application or immunization by hybrid cells would necessitate the verification of the presence of the tumor-associated antigens at each subculture. We are at present experimenting with various in vitro techniques for detection of the expression of these antigens.

Animals↗
PubMed1977

[Report of a case of subcutaneous abscess due to Eikenella corrodens in a splenectomized patient (author's transl)].

A case of subcutaneous abscess of the chest-wall due to Eikenella corrodens is reported in a patient recently splenectomized. This bacillus was grown in pure culture. Processing specimens and identification methods of this little Gram-negative bacillus are described. Eikenella corrodens is a commensal frequently encountered in mucous membrane surfaces. It is likely that this microorganism may be an "opportunist" pathogen.

Abscess↗