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Biomedical subjects

Y Aoki

Publications and source records attributed to Y Aoki.

At least 703 records · Page 39Linked to original sources
PubMed1985

Excretion process of copper from copper pre-loaded rat liver parenchymal cells.

Excretion of copper from copper pre-loaded rat liver parenchymal cells was investigated. The copper pre-loaded cells were isolated from the liver of copper-administered rats and were maintained for 4 days in modified Williams medium E; sodium pyruvate was increased while calcium was reduced in concentration, and 10% fetal bovine serum and insulin were added. For the first 30 hr after plating, loss of copper was slow, with a half-life of more than 100 hr: subsequently the rate of loss was faster, with a half-life of 51 +/- 9 hr. Copper pre-loaded in the cells was mostly bound to metallothionein and the amount of copper-metallothionein decreased with time of culture. Furthermore, the relative ratio of the two iso-metallothioneins changed with length of culture.

Animals↗
PubMed1985

Tumorigenicity study of butyl and isobutyl p-hydroxybenzoates administered orally to mice.

Butyl p-hydroxybenzoate (n-BHB) and isobutyl p-hydroxybenzoate (i-BHB) were administered orally to ICR/Jcl mice at concentrations of 0.6 (maximum tolerated dose), 0.3 or 0.15% in the diet for up to 102 wk. Tumours were observed at various sites including the haematopoietic system, the lung and the soft tissue. However, at none of the sites did the tumour incidence or the time to death with tumours differ significantly from that in the untreated control group.

Administration, Oral↗
PubMed1985

Depression of serum cholinesterase activity by cadmium.

Two serum enzymes which originate from the liver under different circumstances were examined as potential biological indicators in serum for cadmium toxicity. The first of those is an enzyme that leaks from damaged liver cells. The second is an enzyme that is secreted by the normal functioning liver. Cadmium chloride was injected s.c. into male and female rats of the Wistar strain (8, 15 and 22 weeks old), at doses of 1.0, 1.5 and 2.0 mg Cd/kg body weight (in total 18 groups). Cholinesterase (CHE; EC 3.1.1.8) activity in serum was found to decrease with time after the administration of a single injection of cadmium chloride and, in all experimental groups, was significantly lower than the control values on day 2 after the injection. Glutamic pyruvic transaminase (GPT; EC 2.6.1.2) activity in serum, however, increased only in the oldest group of males receiving the high dose levels of cadmium. A time-course experiment in which male and female rats 15 weeks of age were administered 1.5 mg Cd/kg body weight showed that the serum CHE activity started to decrease on day 1 after the injection, attained the lowest level on days 2 and 3, and then recovered almost to control levels on day 5. On the other hand, the GPT activity remained at or less than control values throughout the experimental period. The results indicate that CHE activity in serum is a sensitive biological indicator for cadmium toxicity.

Alanine Transaminase↗
PubMed1985

A mixed germ cell-sex cord-stromal tumor of the ovary with retiform tubular structure: a case report.

An unusual mixed tumor of the ovary in a 7-month-old girl with a normal 46,XX karyotype, is presented. The tumor was composed mainly of small epithelial cells of sex cord type, but also contained multiple foci in which the presence of large cells resembling germ cells warranted the diagnosis of mixed germ cell-sex cord-stromal tumor. An additional histologic feature was the presence in the fibrous stroma of the tumor of tubules of probable sex cord derivation arranged in a retiform pattern. These histologic features suggested that the tumor was a variant of the mixed germ cell-sex cord-stromal tumor of the ovary.

Female↗
PubMed1985

[Radiotherapy of metastatic bone tumor with a synthetic calcitonin derivative (Elcatonin) with irradiation].

Twenty cases of metastatic bone tumors were treated with Elcatonin together with irradiation, achieving pain relief in 47.3% of cases, improved bone scintigrams in 16.7% of cases and radiographic improvement of invaded bone in 7.7% of cases. It has reported that calcitonin is effective for pain relief in 50% of cases but for the radiographic improvement of bone lesions in only 0-10%. The life quality of patients with bone metastases is controversial since treatment techniques for advanced oncological patients has progressed remarkably. The pain relief obtained with calcitonin contributes significantly to improving the quality of life for such patients when administered in combination with conventional treatment modes.

Adult↗