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Biomedical subjects

W Wagner

Publications and source records attributed to W Wagner.

At least 271 records · Page 15Linked to original sources
PubMed1983

[Occurrence and prognosis of medulloblastoma in adult persons].

Between 1962 and 1981, 37 patients with histologically proved medulloblastomas have been treated at the hospitals of the University of Münster. 17 patients died immediately after operation or were, when admitted, in such a bad condition that any therapy was impossible. Since about 1972, the therapy of choice is the operation and post-irradiation of the neurocranium with saturating irradiation of the posterior cranial fossa as well as irradiation of the complete cerebrospinal system down to the second sacral vertebra, because the tumor tends to spinal formation of metastases. Among our patients, twelve were treated in this manner. Before this time, patients were only operated and submitted to an irradiation of the posterior cranial fossa. Eight patients were treated according to this incomplete therapy scheme, five of whom were younger than twelve and three older than fourty years. The tumor was situated in one side of the cerebellum in the three adult patients. The children had a shorter survival time than the adults, except one four years old child who survives already 228 months after the treatment and has to be considered as cured. Our medical records showed at the same time that the course of this disease is considerably worse in infants up to three years than in older patients.

Adolescent↗
PubMed1983

[Occurrence of stationary waves in angiography of peripheral vessels].

Among 229 angiographies of peripheral vascular occlusions performed in 1981 and during the first half of 1982 at the Radiologic Clinic of Münster University, stationary waves developed in one case in the vascular band before the occlusion. This phenomenon can be a pointer towards assuming that over long distances before the occlusion there is no satisfactory outflow provided for by collaterals, intact arterio-arterial or arterio-venous connections.

Aged↗
PubMed1983

[Computed tomographic diagnosis of epidural abscess, subdural empyema, meningitis and brain abscess].

Computerised tomography cannot be of great help in diagnosing meningitis. Examination of the cerebrospinal fluid remains essential. After the inflammation of the meninges has progressed to some stage of encephalitis, the formation of an abscess can be located via computed tomography. It is characterised by the ring-type abscess capsule. Computed tomography for diagnostic purposes is superior to cerebral scanning, which demonstrates enhanced activity, but does not show the formation of a membrane, so essential for differential diagnosis. Furthermore, computed tomography shows the adjacent anatomical structures and answers the questions of displacements and threatening invasion of the ventricle system. Epidural and subdural abscesses can also be located by computed tomography. Therapy can begin directly after computerised tomography, whereas in scintigraphy only a non-specific enhanced activity is present, which often does not allow differentiation between epidural and subdural location.

Brain Abscess↗
PubMed1983

[Current problems in breast cancer].

From 1951 to 1975 1087 patients (1075 women, 12 men) suffering from breast cancer were seen at the Surgical Clinic of Jena (GDR). Late results of 988 patients could now be evaluated. Adjuvant chemotherapy becomes increasingly important due to early metastatic spread after radical surgery. Long-term studies, however, have to be waited for until a final assessment of efficiency can be made.

Breast Neoplasms↗
PubMed1982

Prophylaxis of postoperative epididymitis. Vasectomy or vas ligation?

Preoperative vasectomy for the prevention of postoperative epididymitis in 103 cases is compared to preoperative vas ligation in 132 cases performed by the same surgical team. Both methods showed good results. However, vas ligation is easier to perform and seems to have less complications. The vas ligation procedure is discussed.

Aged↗
PubMed1982

A controlled comparison of two treatments for nocturnal enuresis.

This study assessed change in the frequency of primary nocturnal enuresis as produced by either behavioral conditioning with a urine alarm, pharmacotherapy with imipramine hydrochloride, or assignment to a clinical waiting list. The study also investigated the effect of treatment method and outcome on subjects' level of emotional and behavioral adjustment. An attempt was made to identify pretreatment predictors of treatment outcome and premature withdrawal from the treatment program. The results indicated a significantly more effective outcome for the conditioning approach. Comparison of pre- and post-treatment measures of adjustment provided insufficient evidence to support the hypotheses that either change in the frequency of nighttime wetting or the method of treatment received would influence the subject's level of emotional and behavioral adjustment. The enuresis tolerance scale was found to be a highly significant predictor of early termination from conditioning treatment.

Adolescent↗
PubMed1982

Evaluating mepindolol in a test model of examination anxiety in students.

The effect of a single dose of beta-blocker (5 or 10 mg mepindolol) during a written examination was investigated in two double-blind studies (N : 49 and 55 students, respectively). The question was whether the beta-blocker would in comparison to placebo diminish examination anxiety and improve the performance of highly complex tasks, while leaving the performance of less complex tasks unchanged. A reduction in examination anxiety after beta-blocker intake could not be demonstrated with a multi-level test model (which included the parameters self-rated anxiety, motor behaviour, task performance and physiology), although pulse rates were lowered significantly. An improvement in performance could not be observed, while - by the same token - the performance was not impaired by the beta-blocker. A hypothesis according to which a beta-blocker has an anxiolytic effect and improves performance, dependent on the level of habitual examination anxiety, was tested post hoc, but could not be confirmed. Ten of the subjects treated with 10 mg mepindolol, complained of different side effects, including dizziness, fatigue and headache.

Adrenergic beta-Antagonists↗
PubMed1982

[CT diagnosis of the carotid cavernous fistula and differential diagnosis (author's transl)].

One of the many urgent cases requiring immediate attention is the possibility of continuous bleeding into the sphenoidal sinus via a carotid cavernous fistula (CCF). Computed tomography offers a necessary and quick diagnostic method for such soft-tissue structures. Difficulty in CT diagnosis is enhanced by the limitations inherent in certain diagnoses. The article shows that safe diagnosis can be achieved in acute postoperative CCF with great shunt volumes. When diagnosing spontaneous cases we must consider the clinical data to differentiate CCF from other causes.

Arteriovenous Fistula↗
PubMed1982

[Therapy and prognosis of medulloblastoma].

Between 1962 and 1981, 37 patients with histologically proved medulloblastomas were treated at the Radiologic Hospital and the Children's Hospital of the University of Münster. Because of the inadequate treatment over this long period, the collective was divided into three groups. The first group comprised 18 patients, 15 of whom died after having been operated, so that they could not be submitted to a sufficient radiotherapy. Two patients were unconscious when admitted; they died without therapy. One patient was submitted to a primary palliative irradiation with 10 Gy. The second group comprised seven patients who received only a postoperative irradiation of the skull. One of these patients is alive since 228 months without any recurrence. The other six patients had an average survival time of 9,2 months. The third group comprises twelve patients who were submitted to an irradiation of the skull and an additional irradiation of the whole cerebrospinal axis. Nine of these twelve patients were also treated by chemotherapy according to the SIOP scheme. Their average survival time is 28,4 months. Five patients are still alive and have no recurrences or metastases. The best survival chances actually seem to be provided by a radiotherapy of the whole cerebrospinal axis combined with chemotherapy.

Adult↗
PubMed1981

[Importance of peritoneal lavage in the diagnosis of blunt abdominal trauma (author's transl)].

Peritoneal lavage was carried out in 830 patients with blunt abdominal trauma. Positive as well as negative results proved to be very reliable (98% and 99.5% accuracy). With weakly positive findings, however, significant internal injuries were present in only half of the cases. If compared to circulatory parameters, laboratory investigations and clinical evaluation of the abdomen at the time of hospitalization, peritoneal lavage proved to be the superior aid in making a decision to operate. It therefore should be used routinely--even in smaller hospitals--especially before transferal of a patient to a distant special surgical center.

Abdominal Injuries↗
PubMed1981

Cytokinetic behavior of Ehrlich ascites tumor after in vivo treatment with cis-diamminedichloroplatinum(II) and metallocene dichlorides.

The influence of an in vivo treatment with optimally tumor-inhibiting doses of cis-diamminedichloroplatinum(II) (DDP), titanocene dichloride (TDC), and vanadocene dichloride (VDC) on the DNA distribution pattern, determined by pulse-cytophotometry, and on the mitotic activity of EAT cells is investigated. Whereas DDP causes an immediate and long-lasting decrease of mitoses but no disturbances of the EAT cell kinetics, a marked G2 block with a maximum at 10-12 h a. t. and an irreversible and extensive mitotic depression is evoked by TDC. In the case of DDP and TDC, the tumor cells are removed several days a. t. by cells belonging to the defensive system of the host animals. In contrast, VDC induces partially synchronized waves after a transient suppression of mitoses and reversible cell accumulation in the late S and in the G2 phases. Additionally, 5-16% of the cells become polyploid after VDC treatment.

Animals↗
PubMed1981

In vitro cell growth inhibition by metallocene dichlorides.

The in vitro growth-inhibiting potencies of titanocene dichloride (TDC), zirconocene dichloride (ZDC), hafnocene dichloride (HDC), vanadocene dichloride (VDC), and molybdocene dichloride (MDC) against Ehrlich ascites tumor (EAT) cells cultured in viro as permanently growing suspension cultures were determined. The most striking growth-suppression activity was detected for VDC. A VDC concentration as low as 5. 10(-6) mol/l effects a highly significant diminution of cell proliferation. TDC and MDC inhibit cellular growth only concentration of 5 . 10(-4) or 10(-3) mol/l, respectively, whereas ZDC and HDC, which are ineffective against EAT cells in vivo, require higher concentration levels. The growth inhibition is caused by a cytotoxic action of the metallocene dichlorides, as is demonstrated in the case of VDC and TDC by differentiation of live and dead EAT cells by means of the dye lissamine green.

Animals↗