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Biomedical subjects

W Szyfter

Publications and source records attributed to W Szyfter.

At least 73 records · Page 4Linked to original sources
PubMed1995

[Swallowing disorders in patients after the laryngeal cancer surgery].

Anatomical and functional changes of the oral cavity, pharynx and larynx due to malignant tumor surgery and irradiation, cause breathing, swallowing, phonation and lung protection disorders. Deglutition disorders and choking are observed in all patients who have undergone supracricoid laryngectomy. We presented 33 patients after supracricoid laryngectomy with simultaneous CHEP (6) or CHP (27) reconstructions. 18 patients had one arytenoid cartilage removed, in 1 patient both of them were removed. Removal of the stomach tube took place between 29-36th day after the surgery. 4 patients showed symptoms of the aspiration pneumonia. Difficulties in swallowing liquids persist in some cases even a few years after the surgery. Re-education and rehabilitation of swallowing is the predominant problem and the most important goal after the CHP and CHEP surgery.

Deglutition Disorders↗
PubMed1995

[Voice and spirometric function i patients after expanded fronto-lateral laryngectomy by using the Szmeja method].

The examination was carried out on 32 patients with larynx cancer, before and after fronto-lateral laryngectomy with reconstruction, using cartilage-mucous membrane transplant from the nasal septum. Before and after the surgery the following examinations were carried out: 1. phoniatric evaluation of voice, 2. acoustic analyses of voice, 3. spirometric examination. The phoniatric examination included evaluation of voice characteristics, time of phonation, anatomic mechanism of voice creation and evaluation of voice tiredness with the use of stroboscopy. Acoustic examination included the frequency evaluation of laryngeal sound and its range, jitter shimmer evaluation, harmonic structure of sound and the level of noise. The result obtained allow us to consider the voice and respiratory function as satisfactory.

Adult↗
PubMed1995

[CT examination of the temporal bones for cochlear implantation].

CT examinations of temporal bones were performed in 31 deaf patients from qualify diagnostic stage prepared for cochlear implants. Essential for surgical treatment anatomic details were estimated, especially canalis spiralis cochleae was paid to attention. In our group, 8 patients had some CT changes (abnormal findings) which corresponded to different stages of obliteration the cochlea. The majority of patients lost the hearing because of meningitis. In 6 implanted patients CT scan was compared with surgical findings. During the operation 1 patient with patent cochlea on CT scan had partially ossified basal turn.

Adolescent↗
PubMed1995

[Unilateral prolapse of the laryngeal pouch due to the deformity of the thyroid cartilage].

Our examination included 10 male patients in the age of 40-72. Microlaryngoscopic examination revealed smooth prominence of the larynx vestibule always on the left side concealing partly the vocal fold but with its mobility preserved. Our greatest attention was focused on CT since we expected possible explanation of the asymmetry of the larynx vestibule. That examination disclosed: left-side shift of the thyroid cartilage lamina to the larynx, elongation of the thyroid cartilage lamina and measurements of interlaminar angles revealed contraction of that angle to the value 60-78.

Adolescent↗
PubMed1995

[Estimation of aromatic DNA adduct levels in laryngeal tumors in relation to cancer staging].

Genotoxical agents as PAH, nitrosamines, aromatic amines located in tobacco smoke are responsible for disorders of structure and function of DNA chromosomes, proteins and also initiation of carcinogenesis. DNA adducts are recognized as measure of the biological effective dose of exposure to environmental genotoxicant. So far most studies on DNA adducts after human exposure to tobacco smoke have ben carried out on white blood cells, lungs and oral cavities tissue. The aim of this work was estimation of relationship between state of neoplastic disease (TNM system) and number of aromatic DNA adducts. The subject were 37 patients with primary larynx tumor. In every case histopathological investigation revealed squamous cell carcinoma. There were 33 total and 4 partial laryngectomies performed. From tumour and nontumour larynx tissue DNA was isolated. Analysis of DNA adducts was performed by the 32P-postlabelling method. The results were characterized by individual differentiation. The highest level of DNA adducts was found in larynx tumour cells. In case of strong smokers (30-40 cigarettes per day) the level of aromatic adducts was higher then in non- or ex-smokers. In both tissues (tumour and non-tumour) the highest level of aromatic adducts was in T3 stage, the lowes in cause of T2 stage. In tissues with T4 stage the level of DNA adducts was intermediate. One has been observed decrease tendency in level of DNA adducts which is connected with increase of TNM stage.

Adult↗
PubMed1995

[Metastases in the prelaryngeal (delphian) lymph nodes in the course of the laryngeal cancer].

The metastases in the pre-laryngeal (Delphian) lymph nodes in the course of laryngeal cancer are uncommon. Between 1984 and 1994, 1573 patients with the diagnosis of laryngeal carcinoma were operated at the Department of Otolaryngology of Academy of Medicine in Poznań (Poland). Total laryngectomies were performed in 1069 cases and partial laryngectomies in 504 cases. Pre-laryngeal lymph nodes were identified in 109 patients. Histologically, metastases were found in 8 cases (7.48%). The prognosis of the patients with metastases in these lymph nodes is poor; only 2 patients are alive and free of neoplastic disease.

Humans↗
PubMed1995

[Hearing impairment in children with Down's syndrome].

The purpose of this study was the examination of 60 children with Down's syndrome with particular attention paid to the organ of hearing. The investigation included anamnesis concerning the risk factors of hearing loss, psychomotoric development, otolaryngological examination, pure tone, impedance and speech audiometry. The main conclusion is: hearing impairment is more frequent in children with Down's syndrome (82.8%) than in normal population (0.5-2%). The type of hearing impairment is mainly conductive and mild degree.

Acoustic Impedance Tests↗
PubMed1994

Aromatic DNA adducts in larynx biopsies and leukocytes.

Larynx cancer is strongly associated with tobacco smoking. The objective of this work was an analysis of aromatic DNA adducts in tumour and non-tumour larynx cells by means of the 32P-postlabelling method. Peripheral blood leukocytes were used as a reference tissue. The presence of aromatic DNA adducts was demonstrated in all the studied tissues obtained after surgery of larynx tumours. The highest level of DNA adducts was found in larynx tumour cells, followed by non-tumour larynx cells, which exceeded that found in leukocytes almost 2.5 times. Large interindividual differences were detected between subjects. The adduct level in tumour/non-tumour correlated only moderately. However a high correlation was found between the level of DNA adducts in larynx (tumour and non-tumour) cells and that in leukocytes.

Adult↗
PubMed1994

p53 mutations in larynx cancer.

The objective of this work was an analysis of mutations in the p53 gene detected from fresh tumor samples of larynx cancer patients using single-strand conformation polymorphism (SSCP) and direct DNA sequencing of exons 5-8. From 40 patient samples, 15 showed an extra band in SSCP. In 13 samples mutations were detected in exons 5-8. They constituted six transitions and seven transversions, four of them being T to A transversions. Mutations in codons 205 and 248 occurred in two and in codon 246 in three samples. Larynx cancer is strongly associated with tobacco smoking and alcohol consumption. The typical p53 mutations in lung cancer, G to T transversions and G to A and C to T transitions, associated with smoking, accounted for 46% of the mutations detected. Fifty-four per cent of the mutations were detected in a reported hotspot region covering codons 238-248.

Adult↗
PubMed1994

[The first experience in diagnosis and rehabiliation in patients with cochlear implant "Nuclear Mini System 22"].

The first qualification for cochlear implant "Nucleus" was performed on the basis of audiological tests. Next stage was conversation with a patient and his family about motivation of longterm rehabilitation. Then the two very important investigations were carried out--the computer tomography which showed inner ear structure, and electric promotory test. In rehabilitation process original "Nucleus" partially modified and Polish linguistic articulation lists were used.

Adult↗
PubMed1994

[Parotid gland oncocytoma].

The case of 60 years old man with oncocytoma in parotid gland is reported. According to the available literature there is less than 200 cases reported.

Adenoma, Oxyphilic↗
PubMed1994

[The Poznan program of the treatment of deafness by multichannel cochlear implants].

The authors presented 5 deaf patients with postlingual deafness and application of cochlear implant "Nucleus Mini System 22". In details operative technics and postoperative proceeding were described as well as rehabilitation results in 3-6 months after operation. The authors consider, that in adults with postlingual deafness, application of cochlear implants were giving very good effects.

Adult↗
PubMed1994

[Personal experiences with extended frontolateral laryngectomy and simultaneous reconstruction using a cartilage/mucous membrane transplant from the nasal septum].

From 1979 to 1992, 219 extended frontolateral laryngectomies were performed in Poznań with simultaneous reconstruction of the larynx using a mucochondral nasal septum flap. During following examinations local recurrences were observed in 7 cases and metastases to regional lymph nodes were found in 3 cases. Complete healing of the flap was seen in 172 patients. In these cases the laryngeal lumen was found to be wide and the transplanted mucosa was normal. In 14 patients there appeared to be partial rotation of the flap, narrowing the reconstructed lumen. Among the causes of failure were the use of a too flexible, thin septal cartilage and wound infection. Detailed acoustic recordings of postoperative voices are presented as examples of successful surgery.

Adult↗
PubMed1994

[Surgical management of pituitary adenomas by transsphenoidal approach].

In the years 1976-1993 we have performed 90 transsphenoidal approaches for pituitary adenomas. This paper presents a detail report concerning 23 cases, operated in the last 2 years, with CT and NMR documentation. A preoperative visual deficit was very common in this group of patients. In the postoperative period the dramatic improvement of the vision was observed in 86% of cases. In our opinion the transphenoidal approach is very useful for the operation of the tumors with suprasellar expansion.

Adenoma↗
PubMed1994

[Unasyn in perioperative prophylaxis in patients with laryngeal cancer].

In comparative examination of patients with larynx cancer, the authors evaluated the effectiveness of postoperative prophylactic treatment with Unasyn, which was administered to 25 patients who underwent total laryngectomy. Despite the very varied bacterial spectrum the usefulness and effectiveness of this preparation in preventing inflammatory complications of general and local character.

Ampicillin↗