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Biomedical subjects

W Szyfter

Publications and source records attributed to W Szyfter.

At least 91 records · Page 5Linked to original sources
PubMed1993

[Analysis of the DNA adducts in patients with laryngeal cancer].

There is known a strong association between induction of cancer of respiratory tracts and tobacco smoking. Exposure to polycyclic aromatic hydrocarbons (PAH) present in tobacco smoke can induce DNA lesions including bulky DNA adducts. The studied group consisted of 6 men, aged 46-71 years, all intensive cigarette smokers, without reported occupational exposition to PAH. Treatment did not include radio- and chemotherapy. DNA isolated from surgically removed tumors, surrounding tissue histologically characterized as non-malignant and peripheral blood white cells was analyzed by 32P-postlabelling assay with P1 nuclease enhancement. Both, P1 nuclease digestion and the chromatographic systems used for separation of DNA adducts were established for PAH: DNA analysis. The main adduct was identified as diol-epoxide metabolite of B (a) P. The mean number of adducts in tumor samples, surrounding tissue and white blood cells was calculated, respectively, to 82.3, 59.9 and 41.7 PAH: DNA adducts per 10(8) nucleotides. The only accessible reference was for DNA from white blood cells. The amount of PAH: DNA adducts in white blood cells of larynx cancer patients exceeded that found in healthy blood donors (both: smokers and non-smokers) as well as in workers exposed occupationally to high concentration of PAHs in the ambient air. Hence, it is concluded that carcinogen: DNA adducts as pre-mutagenic lesions can provide a diagnostic information. It concerns the target cells as well as a surrogate tissue. In any case the study has only a preliminary character because of limited number of subjects studied.

Aged↗
PubMed1993

[The usefulness of ultrasound examination in the diagnosis of neck tumors].

Ultrasound examination is a fast, easy to carry out and relatively easily accessible one. This examination allows in the first stage to define the character of the change--cyst-like change, solid change, enlarged lymph nodes, and to establish topographic data, especially the relation to main blood vessels of the neck. The examination of 150 patients with neck changes of tumour type was carried out, the characteristic features of changes in case of solid tumours, benign and malignant ones, cyst-like changes, enlarged lymph nodes were presented. The comparison of the results of the ultrasound examination and the results of histopathological tests shows their substantial compliance.

Actinomycosis↗
PubMed1992

[Supracricoid reconstructive laryngectomy with cricohyoidopexy and cricohyoidoepiglottopexy].

On the base of the personal material, comprising 19 patients with glotto-supraglottic cancer, an operative technique on supracricoid reconstructive laryngectomy with CHP and CHEP has been presented. The data achieved within 3 years allowed to evaluation of preliminary oncological and functional results. In the group of 19 operated patients, one case of local recurrence was found. Cervical recurrence was observed in 2 persons in the first year after the operative treatment. No remote metastases and secondary neoplastic++ focus were found in the digestive and respiratory tract. One patient died of massive pneumonia in the course of disturbances in deglutition. The most difficult problem of the postoperative period in the cases of CHP were the disturbances in deglutition. For that reason pneumonia was observed in 4 patients. Nasogastric tube was left in place for a mean time of 20 to 60 days. All CHEP patients were decannulated and 5 ones out of 14 persons group after the operation of CHP remain with tracheotomy tube.

Anastomosis, Surgical↗
PubMed1991

[Otogenic brain abscesses in children].

In the years 1953-1989 in the Department of Otolaryngology, Medical Academy in Poznań 75 patients were treated for otogenic brain abscesses, among them 19 were children. In the last ten years the number of cases of this complication was not increased significantly in children and adults. In 3 cases abscess was diagnosed in acute otitis media, in the remaining cases it was a complication of chronic otitis media with cholesteatoma. Brain abscesses were situated more frequently in the temporal lobe. In children they developed more frequently on the right side. The survival in temporal lobe abscesses in children was 90%, and in cerebellar abscesses 75%. In adults the survival rate was about 80% for both localizations. In the treatment of these otogenic complications wide radical operation on the middle ear or ++antro-mastoidectomy with exposure of the dura and simultaneous approach to the abscess from the postoperative ear cavity, with puncture of the abscess and replacement of its contents with normal saline with antibiotic is the routine method in the Department.

Adolescent↗
PubMed1991

[Malignant or necrotizing otitis externa].

The authors report one case of the malignant external otitis treated with Ciprobay in 72-year-old diabetic female. They are calling attention to the diagnostic difficulties in the initial period of the disease due to similar clinical manifestations in the chronic otitis. The control examination after 7 months found no recurrence of the Pseudomonas aeruginosa infection.

Aged↗
PubMed1991

[Late results of the treatment of laryngeal cancer by extended fronto-lateral laryngectomy and reconstruction with a muco- cartilaginous transplant from the nasal septum].

The late results of the larynx reconstruction by means of the ++muco-septal nasal graft after an enlarged fronto-lateral laryngectomy were described. The analysis of 118 patients shower a satisfying larynx lumen in almost all cases, there were 9 patients with a partial rotation of the graft. A 5-year survival rate was found in 82% of cases.

Follow-Up Studies↗
PubMed1991

[Malignant neoplasms of the maxilla treated at the Otolaryngological Clinic, Medical Academy, in Poznań 1974-1987].

In years 1974-1987 100 patients with malignant neoplasms of the maxilla were treated in the Otolaryngological Department of the Medical Academy in Poznań. Eleven patients carried on a profession concerned with wood dust. The most frequent complaint was unilateral obstruction of the nose. Short history and at the same time a considerable progression of the neoplasm were conspicuous in those cases. The physical examination was completed by tomograms of the paranasal sinuses and in the last four years scanner examination. Unfortunately in majority of patients extensive neoplastic infiltration was found in stage T3 and T4. In spite of such a large infiltrate, changes in the lymph nodes of the neck were observed only in 14% of patients. The treatment included first of all an extensive operational procedure completed by radiotherapy.

Adult↗
PubMed1987

[Cartilage-mucous membrane transplant from the nasal septum in laryngeal reconstruction following extended frontolateral laryngectomy].

The authors present in detail the method of reconstructing the larynx after extended fronto-lateral laryngectomy using a mucochondrial nasoseptal graft. The method has been used in 61 cases of laryngeal cancer arising not only from the glottis but also from the laryngeal ventricle, the vestibular fold and part of the epiglottis. After describing other reconstruction techniques after vertical laryngectomy the authors point out the advantages of mucochondrial nasoseptal graft.

Cartilage↗