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Biomedical subjects

W Szyfter

Publications and source records attributed to W Szyfter.

At least 55 records · Page 3Linked to original sources
PubMed1999

[Sarcoidosis presenting as isolated nodules of the parotid and submandibular glands].

The authors documented the case of healthy, 50 year old women with a sarcoid lesions of the parotid and submandibular gland without any other manifestations of the disease. The presence of noncaseating granulomas in salivary tissue is a specific feature of sarcoidosis. Primary involvement of the intraglandular lymph nodes with a secondary involvement of the salivary gland parenchyma was detected. Etiopathogenesis, diagnostics and clinical features of sarcoidosis were presented.

Diagnosis, Differential↗
PubMed1998

[Voice acoustic analysis in patients with a hearing aid or cochlear implant].

The subject of our study was two groups of patients with hearing disorders: 23 cases implanted with multi-channel cochlear device (Nucleus Mini System 22) and 10 patients with perceptive hypoacusis who used hearing aids. The voice acoustic analysis was performed before cochlear implantation or application of a hearing aid and after a 6-month rehabilitation period. The acoustic analysis was carried out by means of a laryngophone connected to KAY 4300 instrument. The estimation of acoustic parameters of a laryngeal tone during rehabilitation process as well as parameters of spectrographic analysis was presented with the use of MDVP and CSL. Voice acoustic analysis can be an objective evaluation of progress in voice and speech rehabilitation process of patients with hearing disorders, particularly small children.

Adolescent↗
PubMed1998

[Sex-dependence of larynx susceptibility to tobacco smoke carcinogens. The role of androgen hormones].

According to epidemiological data concerning laryngeal cancer there is almost ninefold higher morbidity in male population than in females. The aim of this study was to analyse on molecular level the genotoxic effects arising under the same exposure to tobacco smoke in males and females. In biopsies received from laryngectomy material we determined levels of aromatic and alkylated DNA adducts in tumours and in adjacent non-tumour tissue. It was established that levels of DNA adducts found in male DNA samples exceeded those in female DNA samples 1.5-3.8 times, which was recognised as a molecular evidence for epidemiological differences. Next, testosterone and sex hormones binding globulin (SHBG) were determined in male subjects blood serum. The levels of testosterone and SHBG very weakly correlated with DNA adduct levels even when subjects were separated into age groups. It is concluded that levels of testosterone and SHBG are not the proper markers of individual susceptibility to genotoxicity of tobacco smoke carcinogens.

Adult↗
PubMed1998

[Neurofibroma of the parapharyngeal space: a case report].

Neurofibroma is rarely found arising in the head and neck region. Parapharyngeal space neurofibroma is one of the rare complications of neurofibromatosis type I, occurring in less than 5% of all parapharyngeal space neoplasms. Solitary neurofibroma type II in this location has not been reported so far in literature. In this paper we describe a case of a huge neurofibroma of parapharyngeal space, indicating the main diagnostic procedures (especially CT scan), and report the surgical treatment.

Female↗
PubMed1998

[Liposarcoma of the neck].

Liposarcoma is a malignant neoplasm of soft tissue. Its occurrence in the head and neck region is extremely rare. The case of a 26-year-old woman with neck liposarcoma is presented. The clinical manifestation, histopathology, possibility and results of the tumor treatment are described according to the literature.

Adult↗
PubMed1998

[Chromosome sensitivity to bleomycin-induced damage in patients with laryngeal cancer as a marker of genetic risk].

An inter-individual variability in sensitivity to mutagen-induced genotoxicity was studied in respect to an estimation of larynx cancer risk. Bleomycin induced chromosome breaks were analysed in blood lymphocytes proliferating in vitro in a group of 35 larynx cancer subjects and in 18 healthy controls. A significantly higher index of chromosome breaks was found in larynx cancer subjects as compared with the controls. The distribution of individual results indicates that subjects oversensitive to bleomycine were identified only among laryngeal tumour patients. A potential usage of bleomycin test in tumour prognosis is discussed.

Adult↗
PubMed1998

[Therapeutic effectiveness of Cedax in the treatment of selected acute upper respiratory diseases].

A group of 66 patients with acute inflammatory upper respiratory tract diseases were examined in the ENT Department of Poznań Medical Academy between November 1996 and November 1997. Specimens for bacteriological cultures were collected from the ear, nose and throat. The subjects were treated with ceftibuten. Clinical improvement was reported in all cases. In 44 patients, ceftibuten treatment eliminated pathogenic bacteria (as evidenced by microbiological analysis).

Acute Disease↗
PubMed1997

Alteration of p53 gene structure and function in laryngeal squamous cell cancer.

The p53 gene is known as an anti-oncogene that manifests its function by controlling the cell cycle and is responsible for apoptosis of cells with unrepaired DNA. An accelerated p53 protein synthesis is the first response of a cell following DNA damage. However, mutations of the p53 gene can disturb protein synthesis or may be responsible for synthesis of a changed protein unable to control the cell cycle. Laryngeal tissue specimens from 120 patients were tested by immunohistopathological staining to detect mutated wild-type p53 protein. It was found that p53-positive specimens correlated with TNM staging and histopathological grading. Another indication of entering the cell cycle and undertaking an active proliferation by laryngeal cells was shown by detection of proliferating cell nuclear antigen (PCNA) and Ki67 nuclear antigen, which appeared in proliferating cells (late G1, S-G2 and M phase), but was absent in resting cells. Scoring of the staining for p53 protein, PCNA and Ki67 correlated with each other. DNA from 40 specimens was then isolated, amplified by polymerase chain reaction and analysed by single-strand conformation polymorphism and DNA sequencing for mutation in the p53 gene. Fifteen DNA samples were found to be positive, while mutations were detected in exons 5-8 in 13 samples. The majority of mutations were found in tissue specimens from T3 and T4 tumors. A possible explanation is almost half was attributable to genotoxic effects of tobacco smoking. Changes in the p53 gene and its products may also reflect early changes in laryngeal carcinogenesis and be of prognostic value.

Adult↗
PubMed1997

[The evaluation of ceftibuten (Cedax) effectiveness in the prevention of perioperative infections].

Cedax is the antibiotic drug of the third generation cephalosporin type. In the Department of Otolaryngology of the University Medical School in Poznań tests were carried out on the effectiveness of this drug in the prevention of perioperative infections (tonsillectomy, adenotomy, septoplastics, nasal polypectomy, mucotomy). The experiment comprised 50 patients who were administered Cedax once a day of the period of five consecutive days, beginning on the day of the surgery. Control group compare 50 patients who did not receive the antibiotic cover. For the comparison of both groups the following symptoms were taken into account: general condition of the patient, body temperature in the first few days after the surgery, the healing of the operative wound (the condition of mucosa, healing "per primam" or "per secundam"), the presence and type of nasal discharge. A high degree of efficiency of ceftibuten has observed.

Adult↗
PubMed1997

[The possibility of tinnitus suppression by electrical stimulation].

The authors described the treatment of 36 patients with persistent tinnitus. In the past the patients were treated with other methods without positive results. After audiological examinations Promontory Stimulator (Cochlear Co.) for electrical stimulation was used. During the electrical stimulation one electrode was inserted in external auditory meatus and the other on planum mastoideum. Bursts of biphasic pulses of 0.1 ms duration were used during electrical stimulation. Electrical stimulation was applied 10 min. during 10 days. The patients estimated effects of treatment and results are presented in table. The authors obtained satisfactory results in 48% of the patients.

Adolescent↗
PubMed1996

Tobacco smoke-associated N7-alkylguanine in DNA of larynx tissue and leucocytes.

The presence of N7-alkylguanine adducts in DNA was analysed in a group of 46 patients with larynx tumours. All patients were subjected to laryngectomy and the tissues accessible for analysis by (32)P-post-labelling assay were larynx tumour, larynx non-tumour and peripheral blood leucocytes. N7-Alkylguanine adducts were detected in all the studied DNA samples. The average level of N7-alkylguanines was 26.2/10(7) nucleotides in tumour cells, 22.7/10(7) in non-tumour cells and 13.1/10(7) in blood leucocytes. There was significantly higher level of N7-alkylguanines in the larynx tissues in males than in females. The effect of tobacco smoking on DNA adduct levels was shown by an increase in the average levels of N7-alkylguanines in the subject groups classified according to their smoking habits. A moderate age-related increase in levels of N7-alkylguanine was demonstrated in larynx tumour tissue. The levels of N7-alkylguanine adducts in larynx cells were compared with that of aromatic DNA adducts. Pearson correlation coefficients (0.28 for tumour tissue and 0.30 for non-tumour tissue) indicate independent formation and removal of N7-alkylguanine and aromatic DNA adducts resulting from tobacco smoke exposure.

Adult↗
PubMed1996

[Correlation between the clinical stage of larynx cancer in male and female and levels of steroid hormones in serum].

264 patients with cancer of larynx, 21 female and 234 male, had a testosterone and sex hormone binding globulin (SHBG) before the treatment in serum estimated. Because of dependence of levels of hormones the group of patients was divided into three following groups: "lower than standard", "standard", "higher than standard". The correlation between these groups and sex, age, localization of tumor, organs' advances, stage of morphological malignancy and type of cancer was reported. Anomalous values of testosterone were in male group more frequently reported. Anomalous values of SHBG were similar in male and female groups, but in the female group there was a significant majority of "lower than standard" values reported. The majority of abnormal values of testosterone and SHBG was described in groups of age higher than 50 years. There were no differences in testosterone and SHBG levels in different localization of tumors in larynx. In advanced stage T3 and T4 there were more frequent lower mean values of testosterone levels and higher values of SHBG levels in comparison to T2 stages. In tumors in G1 and G2 stages of histological malignancy higher levels of SHBG and higher mean levels of testosterone. The tumors in stage G3 the hormone levels were lowers were observed. The levels of SHBG in groups of carcinoma planoepitheliale keratodes were in 66% higher than in a group of carcinoma planoepitheliale akeratodes but in both groups the levels of testosterone were nearing the same. In group of patients with larynx cancer the negative correlation between the levels of testosterone and SHBG was not observed. Higher SHBG levels were not always accompanied by lower testosterone levels.

Adult↗
PubMed1996

[The use of mucosolvan in ENT diseases. Part I].

The paper presents an evaluation attempt af Mucosolvan in the upper respiratory tract diseases. A group of 50 patients underwent observation. They were hospitalized in our Department due to acute and chronic inflammations of respiratory tract, malignant tumours and larynx, and trachea stenosis. In cases of larynx and trachea stenosis there occur disturbances in the cleaning of surface of mucosa. Normally, it is done by means of mucociliary system. In the modern postoperative therapy mucolitic preparations are very useful.

Adult↗
PubMed1996

[On classification of changes in necrotizing lesions of the midface].

Lethal midline granuloma syndrome (LMG) describes lesions of the midface and is characterized by a progressive and often fatal ulceration and destruction of the upper air way involving the nose, the paranasal sinuses, the palate and the soft tissues of the face. Under the term LMG we distinguish four entities: idiopathic midline destructive disease (IMDD), polymorphic reticulosis (PR), non Hodkin's lymphoma and Wegener's granulomatosis (WG). Review of the literature allows to present the differential diagnosis making use of latest technological achievements in clinical immunology and immunohistochemistry. First of all the LMG must be discriminated from localized WG occurring in the midface. The clinical, serological and histopathological findings in WG are described. Literature review is carried out and recent concepts of it's etiology and pathogenesis are presented. Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA) with specificity for proteinase 3 (PR 3) are valuable marker for differential diagnosis and specificity are discussed. We make a comparison between the "limited" or "non renal" WG and "classical" or "renal" form of the disease.

Adolescent↗
PubMed1996

The acoustic analysis of voice in patients with multi-channel cochlear implant.

The acoustic analysis of the voice was performed in 5 implanted patients (2 children and 3 adults). This analysis was made twice in each patient one week before the implantation and the second time at least three months later. The examination was carried out using the KAY Electronics 4300 instruments and the MDVP program. The comparison of the results showed: decreased F0 value of phonation tone after the surgery in all patients; mean values of jitter and shimmer were increased in relation to norm before and after the surgery in adults and children; the gap between harmonic signal and noise (NHR) was within norm in 2 adults, and in 1 child with prelingual deafness significantly decreased after the surgery. The acoustic analysis of voice of cochlear implant patients, especially children, may be the objective evaluation of progress in speech and hearing rehabilitation. In the process of rehabilitation tendencies pointing out to the normalization of voice especially in patients with prelingual deafness was observed.

Adult↗
PubMed1996

[The use of mucolytic preparations (Mucosolvan) in nasal and paranasal sinuses in children].

In recent years there has been observed an increase in the infections of nose cavity and paranasal sinuses. This phenomenon is connected with a multidirectional alergization of the environment also with the insufficiency of conservative and surgical treatment. Messerklinger's research concerning cilial movements of mucosa in nasal and paranasal sinuses together with his endoscopic experiments are the basic for modern therapy of nasal and paranasal sinuses. In this paper 40 cases of acute and chronic inflammation of paranasal sinuses in children between 3 and 16 years of age were presented. In all cases regardless of the used method of conservative or surgical treatment children were given mucolytic preparations in the form of Mucosolvan by Boehringer Ingelheim. In all observed cases we noticed the shortening of the normal period of the antiinflammatory antibiotic treatment. A part from that, mucolitic preparations due to the decrease of mucous adhesiveness to the walls of paranasal sinuses allow for its evacuation largely decreasing the pain. After FESS treatment, the administration mucolytic preparations causes a factor regeneration of cilial epithelium, proper functioning of cilia and the speeding of mucocilial trnasport, which makes the recovery of an ill child much quicker.

Acute Disease↗