[Status quo in lipid diagnosis from the internal medicine viewpoint].
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Apolipoproteins B↗
Biomedical subjects
W Reuter
Publications and source records attributed to W Reuter.
[Serum magnesium and heart arrhythmias in patients with pelvic-leg arteriosclerosis].
In 122 male patients with arteriosclerosis of pelvis and legs up to 5 resting electrocardiograms were registered in the course of 4 years. 5.2% of these electrocardiograms showed disturbances of rhythm. In these cases no significant differences in the serum magnesium level could be ascertained between patients with and without disturbances of rhythm.
Arrhythmias, Cardiac↗
[Modification of vasoprotective omega-3-fatty acids--a previously unknown side effect of propranolol therapy?].
Under influence of a 6-month treatment with 75-100 mg/d propranolol (Obsidan) a significant decrease of the proportions of eicosapentaenoic acid (C20:5) in the serum was observed in 18 patients with primary hypertension stage I. The eicosapentaenoic acid belongs to the omega-3-fatty acids known as vasoprotectively effective. The results indicate an up to now unknown side effect of the propranolol therapy which is to be seen in the connection with other unfavourable effects in the lipid metabolism. The possible influence on the omega-3-fatty acid metabolism by propranolol should continue to be investigated.
Adult↗
[Status quo of lipid diagnosis from the internal medicine viewpoint].
For the prevention and therapy of metabolic and cardiovascular diseases every internal specialist needs basic knowledge of a rational diagnostics of lipids. The basic analytics of lipids must take into consideration (as to computation) total cholesterol, HDL cholesterol, triglycerides and LDL cholesterol. According to the newest publications of the European Society for Atherosclerosis is orientated to a total cholesterol of 5.2 mmol/l and to triglycerides of 2.3 mmol/l, in order to keep the character of the atherogenic risk as insignificant as possible.
Humans↗
[Initial experiences with the effect of chronic intermittent electromyostimulation in patients with hyperlipoproteinemias and arterial circulatory disorders].
Metabolic and clinical effects of an original electromyostimulation are explained which induces muscle contractions by changes of the field intensity in the region of microseconds in forms of delivered impulse groups. On account of the good local compatibility due to optimal irritation parameters the muscle stimulator was suitable for a long-term application. Examinations on 23 patients with hyperlipoproteinaemia and mixed HLP (n = 15) and primary hypercholesterolaemia (n = 8) after a 2 times 2 hours/day mutual stimulation of the femoral musculature in a frequency of 2 s-1 lasting four weeks yielded a significant decrease of the triglyceride and cholesterol concentrations as well as an increase of the HDL-cholesterol in mixed HLP-forms. Examinations not yet finished refer to an increase of the extrahepatic activity of the postheparin-lipoprotein lipase and to the concentration of the HDL2-cholesterol. An influence of the hypercholesterolaemia IIa could not be made evident. An electrostimulation performed for 3 months in 8 patients with obliterating arteriosclerosis resulted in a more sufficient collateral blood supply of the legs. The long-term use of the device was unobjectionable also under ambulatory conditions. On the basis of additionally gathered experiences further indications of an electrostimulation were cited. Possible variations of the electrostimulation irritation parameters might make accessible further fields for the preventive and curative medicine.
Adult↗
[Indications for the determination of blood lipids].
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Arteriosclerosis↗
[Behavior of cholinesterase activity in lipid metabolism disorders].
In the serum of 127 patients with hypercholesterolaemia, hypertriglyceridaemia and mixed HLP the cholinesterase activities were determined. In hypercholesterolaemia they did not differ from persons with healthy metabolism, however, in hypertriglyceridaemia and mixed HLP were significantly increased. As the cause of increased cholinesterase activities an increased secretion of VLDL in the liver is discussed.
Cholinesterases↗
[Adipocyte volume and count in obesity during weight reduction].
In the subcutaneous fatty tissue of 27 adipose patients the number and volume of adipocytes were determined before and after a stationary weight reduction. 47 normal test persons served as comparison. Under stationary weight reduction the volume of adipocytes significantly decreased, whereas the number of adipocytes remained constant. The subdivision of the obesity according to the cellularity of the fatty tissue into a hypertrophic and a hypertrophic hypercellular form is proposed. A possible indication for the determination of the volume of fat cells in adipose patients is given.
Adipose Tissue↗
[An eicosapentaenoic acid-rich diet in relation to a reducing diet and physical training].
The effect of a mackerel diet alone or in connection with reducing diet and physical training has been tested during 4 weeks in 49 male patients with cardiovascular diseases undergoing a cure and in 45 males with healthy metabolism. 1st group: 15 persons with healthy metabolism, 240 g/die supplementary mackerel diet, no physical training; 2nd group: 16 cure patients with reducing diet (5,000 kJ/d), no mackerel diet, no physical training; 3rd group: 14 cure patients with reducing diet and a proportion of mackerels of 125 g/d, no physical training; 4th group: 19 cure patients with reducing diet and mackerel diet 125 g/d as well as daily swimming training (20 to 30 min). The decrease of beta-C and Apo B was most distinct in groups 3 and 4 and lay between 21 and 35%. The combination reducing diet with proportion of mackerels proved to be most effectively for the decrease of the atherogenic LDL and was superior to the monotherapies. A significant increase of the HDL (measured in alpha-C and Apo A) took place only in group 4 with simultaneous performance of physical training, alpha-C increased by 31 and Apo A by 8%.
Adult↗
[Cystosarcoma phyllodes of the breast: clinical and morphological study of 17 cases].
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Adult↗
[Postprandial hyperlipemia, circadian rhythm and the stress test in lipid metabolism].
Functional tests and daily profiles allow more exact insights for the diagnostics and management of the therapy in disturbances of fat metabolism than the momentary establishment of the fasting lipids. Circadian rhythms are reported particularly for lipoproteins rich in triglycerides, triglycerides, HDL fractions, lipolytic and lipogenic enzymes. The postalimentary hypertriglyceridaemia depends upon the distribution and the composition of food as well as upon individual differences (e.g. sex). The connection to the HDL metabolism is of particular importance. The interaction of the lipoprotein fractions in the circadian course has still many open questions. Results with an oil tolerance test are presented and discussed.
Adipose Tissue↗
[Relation between obesity and atherogenic risk factors in a longitudinal study].
Since 1980 clinical, biochemical and anthropometric examinations have been performed annually on 46 adipose patients (25 males, 18 females) and 53 test persons (35 males, 18 females) at the age of 25 to 40 years. Several of the established parameters (e. g. cholesterol, triglycerides, uric acid, blood pressure among others) in the course of the 5 years within the known normal regions drew towards the adequate limiting value to the pathological. The results of the study clearly show the central role of the overweight for the formation of risk factors. Despite the partly only in a certain tendency recognizable behaviour of individual signs after 5 years from our point of view the longitudinal technique represents itself as a very well suitable method to realize dynamic processes and risk factors of ageing.
Adult↗
[Nutrition and aging].
Proceeding from experiences with animal-experimental studies is tried to show all those mechanisms which have influence on the ageing process of man. In these cases in the experimental part of the study is particularly investigated the influence of the restriction of food in obese patients on the cardiovascular system, the lipid metabolism and the biological age. In obese patients of middle age by isocaloric reduction diet a normalisation of the at present changed non-invasive cardiodynamic parameters could be achieved. Apart from a normalisation of cholesterol and LDL-cholesterol, however, a decrease of the HDL-cholesterol of the same intensity was found. The biological age could be influenced under restriction of food. To what extent overweight and food restriction in man closely correlate with the life expectancy remains the subject of further investigations.
Adult↗
[Treatment of disorders of lipid metabolism with the new lipid regulator X50].
With the newly developed lipid regulant X 50 = 1-benzyl-3-(1-carboxyl-methylethoxy)-4-methylpyrazol 15 patient with primary hypercholesterolaemia and hypertriglyceridaemia were treated for 3 months. A significant decrease of the serum triglycerides by 47% in all patients and of the total cholesterol by 32% in half the patients (LDL cholesterol decrease 25%) was the result. Altogether an increase of the linoleic acid of 14% and a decrease of the uric acid of 16% were furthermore the result. There were practically no side effects.
Apolipoproteins↗
[Results of a long-term study of arteriosclerotic circulatory disorders with polyene fatty acid therapy].
The antiatherogenic oil diet as one factor of therapy causes the hope of favourable effects in the complex primary prophylaxis. By means of this alone, however, a regression of a clinically significant arteriosclerosis cannot be achieved within 3 years, through biochemically unequivocal "antiatherogenic" effects are to be proved. Linseed-oil, fish and fish oil seem to be particularly suited to cause these effects desired.
Arteriosclerosis Obliterans↗
[Lipids and apolipoproteins in relation to the degree of coronary sclerosis].
86 male patients with 0-, 1-, 2- or 3 vascular disease who underwent coronary angiography as well as a control group were examined with regard to their lipoprotein constellation: total (TC-), LDL-, HDL-, beta- and alpha-cholesterol (C); triglycerides; apolipoproteins A, AI and B. Significant differences between the mean values of the control group and the patients with coronary disease were found for the groups with 2- and 3-vascular disease for the following parameters: TC, HDLC, TC/HDLC, LDLC/HDLC, alpha-C, TC/alpha-C, beta-C, alpha-C. The quotients TC/HDLC and TC/alpha-C most closely correlate with the degree of the coronary sclerosis. In the apolipoproteins A, B and the index Apo B/A the patients with coronary disease of the groups 0-3 possess equally lowered or increased serum levels and number values, respectively, in comparison to the control group. The apolipoproteins do not show any relationship to the degree of severity of the coronary sclerosis. By means of the parameters combination (Apo A + TC/alpha-C) with a diagnostic sensitiveness of 0.83 and a specificity of 0.87 a coordination coronary disease--healthy could be performed. The classification according to risks should then be performed by means of a cholesterol quotient (TC/alpha-C or TC/HDLC).
Apolipoproteins↗
Synthesis and antimicrobial activity of 7 alpha-methoxypyrimidinyl-ureidocephalosporins.
The synthesis of a series of 7 alpha-methoxy-7-[(R)-2-[3-[5-pyrimidinyl]ureido]-2-(4-hydroxyphenyl) acetamido]-3-cephem-4-carboxylates 2 is described. 7-[(R)-2-[3-[2-(p-Aminosulfonyl)-anilino-4-hydroxy-5-pyrimidinyl]ureido- 2-(4-hydroxyphenyl)acetamido]-7 alpha-methoxy-3-[(1-methyl-1H-tetrazol-5 -yl)thio]methyl-3-cephem-4-carboxylic acid, sodium salt (2k, UG-FA 132), has exhibited a broad range of antimicrobial activity. UG-FA 132 is highly active against Gram-positive and Gram-negative organisms, including Pseudomonas and lactamase producers, and shows potent activity against anaerobes. The high efficacy of UG-FA 132 was confirmed by in vivo experiments in mice.
Animals↗
[Changes in noninvasive cardiovascular parameters by inpatient weight reduction].
36 normotensive obese and 23 hypertensive obese were treated with an isokaloric reduction diet of 800 kcal/a day under clinical conditions over a 4-week span. Blood pressure and cardiac performance were investigated by means of non-invasive techniques such as systolic time intervals (STI) and calculated indices. A significant decrease was established in systolic time intervals such as left ventricular ejection time and total electromechanical systole, systolic and diastolic blood pressure, myocardial oxygen consumption and cardiac output. Heart rate, preejection index and stroke volume were not diminished under dietary treatment. No decrease of all parameters was found in obese normotensives with a weight reduction greater than 5% after dietary treatment.
Adult↗