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Biomedical subjects

W Mohr

Publications and source records attributed to W Mohr.

At least 73 records · Page 4Linked to original sources
PubMed1991

Deposition of amyloid of unknown origin in articular cartilage.

Articular cartilage, obtained from the large toe during hallux valgus operations in 37 patients, was investigated for the presence of amyloid by using the Congo red staining method. Amyloid deposits were demonstrated, particularly in the superficial layer of the cartilage, in 30 cases. This amyloid did not react immunohistochemically with any of the antibodies against the known five major amyloid types (AA, A lambda, A kappa, AF, AB). From these data it is concluded that hyaline cartilage in older individuals is prone to infiltration by an amyloid of a hitherto unidentified class. From the morphological observations there seems to be no correlation between amyloid deposits and the development of osteoarthrosis.

Aging↗
PubMed1991

Unilateral extended amyloidosis of the renal pelvis and ureter: a case report.

Localized amyloidosis of the genitourinary tract is a rare phenomenon. The differential diagnosis between amyloidosis and malignancy is difficult. We report the case of an 81-year-old man with extensive unilateral localized amyloidosis of the renal pelvis, ureter and ureteral orifice. Diagnosis of amyloidosis was confirmed only postoperatively.

Aged↗
PubMed1991

[Digital roentgen analysis as a tool for kinematic studies of the shoulder--a study of radiation dosage].

The radiation exposure during biomechanical investigation of the shoulder joint done with a digital radiography system (Polytron 1000 VR - Siemens) was measured experimentally. Total radiation dose and surface dose were determined by phantom measurements. The radiation exposure per image is about 1/6 to 1/7 of that of a conventional study. The digital radiography system used is thus suitable for kinesiologic studies of large joints in healthy volunteers.

Humans↗
PubMed1991

[Paragangliomas of the carotid body--clinical problems and therapy].

24 carotid body tumors in 21 patients (1970-1990) have been analysed retrospectively. These well vascularized tumors are growing slowly in the carotid bifurcation and often cause failures in diagnostic and therapeutical approach. 66% (14) have been operated on partially 2-3 times with wrong diagnosis (cervical gland, lateral cervical cyst and others) in other hospitals. It is important to come to an early diagnosis by the typical trias according to Fontaine and Kocher by CT-scan and arteriography. The best method of operation is the so-called technique of transsection, which is also applicable in advanced tumor state (type II-III according to Linder). In tumors, which are beyond radical operability, good cosmetic and functional results can be achieved by partial resection.

Adult↗
PubMed1991

[Changes in the form of perigraft reaction].

Perigraft-reaction is characterized by a late fluid accumulation around a graft. As a rule bacterial contamination is missed. The fluid has the same characteristics as blood serum. An aggressive surgical approach is necessary. The cyst wall must be excized and the prosthesis has to be replaced by a different synthetic material. In these cases a healing can be expected in more than 90%. By using the same material after resection of the cyst wall is followed by a recurrence rate of 79%.

Blood Vessel Prosthesis↗
PubMed1990

[Morphologic changes in the early stages of arthrosis].

"Joint failure" may be the result of different pathological conditions. While in some arthropathies initial changes prior to secondary cartilage destruction may be observed morphologically, the early changes in "mechanically induced" osteoarthrosis are not well known. In the present paper the ultrastructural events, eventually leading to osteoarthrotic cartilage destruction are presented. From the morphological changes it is assumed that the primary lesion leading to cartilage destruction may be seen in the loss of the granular surface microstructures of cartilage that may be followed by an increased hydration and thereafter chondrocytic death with destruction of cartilaginous matrix.

Cartilage, Articular↗
PubMed1990

[ Topography of carpal bone - An experimental model for carpal tunnel syndrome ].

By preparing a new experimental model for the carpal tunnel syndrome, the authors evaluated the differences of the human and rabbit carpal tunnels using a comparative anatomical study. A nearly identical situation-regarding the osseous and connective tissue formations in the carpal channel--was found. Therefore, the carpal tunnel of the rabbit is recommended for a model of chronic nerve compression, which is now planned by the authors.

Animals↗
PubMed1989

New techniques of analyzing the healing process of artificial vascular grafts, transmural vascularization, and endothelialization.

Beside traditional techniques (light, immunofluorescence, transmission electron (TEM)- and scanning electron microscopy (SEM), a new more sensitive method for producing microcorrosion casts using a polyester-based resin has been developed. The SEM analyses of the microcorrosion casts of alloplastic vascular grafts was realized in an absolutely stable stage of polymerization. For the first time, a transprosthetic vascularization could be shown in great three-dimensional detail. The importance of a complete and rapid endothelialization of artificial vascular grafts is discussed.

Animals↗
PubMed1989

New observations on the healing process in prosthetic substitution of large veins by microporous grafts--animal experiments.

Based on the experimental experiences in more than 180 implantations of different materials as venous substitutes segments of the inferior vena cava have been replaced in 34 dogs by Polyurethane (low microporosity) and modified e-PTFE prostheses (increased microporosity of 60 microns and 90 microns fibril length). The 12 months patency rate didn't differ between both tested optimized materials and ranged from 43 to 50%. After a follow-up of 12 months the grafts were taken out and analysed by light, immunofluorescence microscopy, scanning and transmission electron microscopy. In addition a new technique of microcorrosion casts was used for SEM-analyses. As a result a transmural microvessel system in the microporous meshwork of the prostheses with multiple orifices at the inner surface of the grafts could be demonstrated. Complete endothelialization was only observed in e-PTFE prostheses of high microporosity (greater than 60 microns fiber length). There is strong evidence that a full tissue incorporation of microporous artificial grafts mainly depends on a sufficient primary intramural deposit of blood components (fibrin, platelets, leucocytes), which initiates cell invasion from the surrounding tissue, accompanied by a highly developed microvessel network. A multifocal endothelialization takes place from the numerous microvascular orifices on the inner surface of the prostheses. Other sources such as pannus invasion or adhesion of multipotent cells from the blood stream play probably a very limited role.

Animals↗
PubMed1988

[Mesenteric fibromatosis in childhood].

A case of omento-mesenterial fibromatosis in a 6-year-old boy revealing through acute intestinal obstruction is reported. Mesenterial fibromatosis, also known as aggressive fibromatosis or desmoid tumor is generally associated with Gardner's syndrome but otherwise an extremely rare disease. Fibromatoses do not metastasize but are characterized by a high incidence of local recurrence. Primary treatment is operative. After multiple recurrence irradiation, cytostatics and antiestrogens have been used additionally to control the disease.

Child↗
PubMed1987

[Surgical interventions in psoriatic arthritis].

As a general disease, psoriatic arthritis (which besides the skin and the joint can also affect internal organs) takes a special place amongst chronic polyarthritis conditions. It is characterized by combination of psoriasis with a seronegative polyarthritis affecting the spine and above all the joints in the hands and feet (frequently asymmetrically). The form and extent of the often painful joint and spinal involvement not uncommonly lead to an appreciable impairment of various functions and thus to a handicap for the patient. A series of different operations extending from synovectomy to arthrodesis and joint replacement improve the pain as well as functional restrictions. However, they also lead to new knowledge on the nature, etiology and development of this disease via photographic documentation of findings and investigation of the tissue obtained intraoperatively. In the years 1967 to 1984, 457 single operations were carried out in 80 patients with psoriatic arthritis. The results allow the conclusion that patients with psoriatic arthritis should be admitted to special hospitals for surgical treatment more frequently than was the practice up to now.

Adolescent↗