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Biomedical subjects

W Mohr

Publications and source records attributed to W Mohr.

At least 91 records · Page 5Linked to original sources
PubMed1987

[Sonographic findings in 133 malignant breast tumors in relation to their connective tissue content].

The sonographic results of 133 histologically proven breast malignancies are reviewed retrospectively and compared with the physical, mammographic and histopathologic findings. All tumours are classified in three groups according to their cell-fibrous tissue relation. The ultrasound features that are typical of each category are demonstrated and discussed. A close relationship is found between the sonographic findings and the amount of connective tissue in breast carcinomas. Tumours with a predominance of fibrous tissue show sonographic characteristics regarded as typical of malignancy, such as irregular form, hazy contours, heterogeneous internal echos, and dorsal acoustic middle shadow. In contrast, ultrasound findings suggestive of benign lesions--regular form, smooth contours, increased dorsal echos--prevail in carcinomas with little connective tissue. Because of its superior accuracy in detection of carcinoma in radiodense breasts, sonography is a useful complementary method to mammography. On the other hand, echography cannot replace mammography as a screening method, since its sensitivity in detecting non-invasive and small carcinomas is distinctly lower.

Adult↗
PubMed1987

The combined anterior cruciate and medial collateral ligament replacement by various materials: a comparative animal study.

On 30 sheep, a combined replacement of the anterior cruciate and medial collateral ligament of the right knee was performed with four different materials. Dacron prostheses and glutaraldehyde-preserved bovine tendon prostheses as well as braided ligament prostheses made of carbon fibers and braided resorbable polydioxanone fibers surrounded by lyophilized dura in their intra-articular part were used. Ten unoperated sheep served as a control group. After 1 year the animals were sacrificed and the knee joints were explanted and biomechanically as well as histomorphologically investigated. The gross inspection of the joints showed no ruptured medial collateral ligament replacement but did show partially and totally ruptured anterior cruciate ligament replacements. The Dacron prosthesis was broken in 50% of the cases, whereas for the other materials one ruptured ligament replacement each (12.5%) could be observed. The anterior drawer test and the determination of the tensile stiffness of the remaining ligament replacements revealed that none of the operated knees achieved the properties of the normal control knees. However, the carbon fiber implants had the best result of all prostheses tested. For all materials except the resorbable polydioxanone, abrasion particles could be found in the anterior cruciate ligament and in the synovial membrane. The tissue reaction to these particles was a mild synovitis for carbon fragments, a strong synovitis for Dacron particles, and a chronic inflammatory response to bovine tendon fragments with macrophage granulomas and fibrosis.

Animals↗
PubMed1986

Proliferation of pannus tissue cells in rheumatoid arthritis.

Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poor in lymphocytes and plasma cells, and perhaps in those areas of destroying pannus tissue that exhibited polymorphonuclear granulocytes (PMNs) at the pannus-cartilage junction. These results are in contrast to the idea that pannus tissue is a tumor-like lesion, for the present observations, even within the limits of autoradiographic investigations on a heterogeneous tissue, and indicate that pannus tissue has to be regarded as an inflammatory granulation tissue.

Arthritis, Rheumatoid↗
PubMed1986

[Pathomorphologic aspects of the conservative therapy of arthroses].

The paper reviews the different ways in which osteoarthrosis can occur. Structural alterations that take place in the subchondral bone or in the collagenous network of the superficial or mid-zone cartilage can be regarded as the initial events leading to injuries of the chondrocytes. Loss of cartilage either due to increased enzymatic degradation and/or reduced synthesis of proteoglycans may follow. The hypothetical influence of pharmacotherapy on several pathogenetic steps is discussed. However, from the viewpoint of a pathologist, it is concluded that there is no pharmacotherapeutic regimen that can significantly influence the natural course of the disease.

Bone Diseases↗
PubMed1986

[Subcutaneous leiomyosarcoma of the hand].

Leiomyosarcoma of the hand is a rare tumor. A case report of a leiomyosarcoma lying in the superficial tissues of the dorsal aspect of the right hand in a 64-year-old woman is given. Nine months after initial excision a local recurrence appeared and was treated by radical local excision and free skin grafting. The follow-up is now seven years. The patient is free of tumor and metastases. A review of the literature is given. The problems in therapy of leiomyosarcoma of skin and superficial tissues are discussed.

Female↗
PubMed1985

S-100 protein in normal, osteoarthrotic, and arthritic cartilage.

The occurrence of the S-100 protein was studied in normal and pathological cartilage from patients with osteoarthrosis and rheumatoid arthritis. In normal cartilage all cells of the different zones exhibit immunoreactivity for this protein. An identical distribution is observed in cases of osteoarthrosis and rheumatoid arthritis. Cellular pannus tissue usually is devoid of the S-100 protein. However, if chondroid metaplasia occurs in this tissue the cells become positive for the S-100 protein. From these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes.

Adult↗
PubMed1985

Desmoplastic fibroma of the rib.

We present a 17-year-old male patient who had a desmoplastic fibroma. The diagnosis is histologically verified and differentiated from other tumors. The rare localization of this benign lesion in the rib is of particular interest.

Adolescent↗
PubMed1985

Proteoglycans from human articular cartilage: the effect of joint location on the structure.

Proteoglycan monomers from the articular cartilages of the knee, hip and shoulder of 3 subjects (21, 26 and 45 years old) were isolated and analysed. The proteoglycan monomers from the high weight-bearing knee and hip joints were smaller than those from the low weight-bearing shoulder joints and both had a lower chondroitin sulphate content. The proteoglycan monomers from knee joint cartilage had the lowest intra-individual chondroitin-4-sulphate content in each case. Hyaluronate binding capacity was not found to be dependent on joint location.

Adult↗
PubMed1985

[Testicular and epididymal metastasis of prostate cancer].

Metastatic testicular carcinoma is unusual. A case of carcinoma of the prostate with metastases to the testis and epididymis is reported. Routes of metastatic spread of neoplasm to the testis are discussed. Easily removable cancer may remain in the scrotum when using the socalled subcapsular orchiectomy without complete removal of the scrotal contents.

Adenocarcinoma↗
PubMed1984

The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint diseases. II. The localization of mononuclear cells as detected by monoclonal antibodies directed against T-lymphocyte subsets and natural killer cells.

Tissue specimens of synovial membranes from patients with rheumatoid arthritis (RA) and non-inflammatory joint diseases were analyzed with a panel of monoclonal antibodies directed towards T-lymphocyte subsets and natural killer (NK) cells. In the RA group, mononuclear cell infiltrations in the synovium presented a distinguished pattern as compared to the non-RA group. Inflammatory synovial membranes displayed an increased level of cells recognized by the monoclonal antibodies OKT4 and OKT8, especially attributable to the broadened layer of synoviocytes and to the fibrous synovial tissue. No significant difference in the RA patients was observed with regard to the percentage of OKT4 and OKT8 positive cells in different investigated compartments of the synovium, e.g., diffuse inflamed synovial tissue, fibrous synovial tissue, and perivascular infiltrations. OKT4 and OKT8 positive staining was additionally observed on spindle-shaped cells present in the fibrous and diffuse inflamed synovium. OKT10 binding cells were located in the deeper layers of synoviocytes, in the inflamed synovial tissue, and in one case in perivascular areas, whereas HNK 1 positive cells were scattered in the fibrous synovial and perivascular cells, as well as in lymphocyte clusters of synovium in RA patients.

Antibodies, Monoclonal↗
PubMed1984

Polymorphonuclear granulocytes in rheumatic tissue destruction. VI. The occurrence of PMNs in menisci of patients with rheumatoid arthritis.

The meniscal surfaces from patients with and without inflammatory joint diseases were investigated for the presence of superficially located polymorphonuclear granulocytes (PMNs). In histochemically stained tissue sections as well as in electron microscopic investigations on previously paraffin-embedded menisci, PMNs were observed in cases with inflammatory rheumatoid joint diseases. The inflammatory cells were located in fibrin adhering to the meniscal surface and in the fibrous meniscal tissue just beneath the fibrin. From these observations it is concluded that PMNs in the inflammatory synovial fluid may gain access to the fibrous structures of the joint, thus participating in tissue destruction, as has been assumed from in vitro investigations by other authors.

Arthritis, Rheumatoid↗
PubMed1984

Effect of piroxicam on structure and function of joint cartilage.

In vitro experiments were performed on isolated articular chondrocytes under the influence of piroxicam. It was demonstrated that this non-steroidal anti-inflammatory agent affected neither cell proliferation nor the incorporation of 35SO4 into matrix macromolecules. Dogs were treated with piroxicam for 8 weeks. Morphological studies were performed on the tissues of the knee joints. Macroscopic and light microscopic investigations revealed no structural differences between the tissues (synovial membrane and articular cartilage) of control and treated dogs. Even at the ultrastructural level no alterations in the cartilage were observed. The capacity of chondrocytes to incorporate 35SO4 under in vitro conditions was identical in control and experimental animals. It is concluded that piroxicam has no adverse effect on chondrocytes under in vitro conditions or on articular cartilage structure in the in vivo model.

Animals↗
PubMed1984

[Synovial sarcoma of the larynx. Case report and brief review of the literature].

Synovial sarcomas are connective tissue tumours. In most instances they are located at the extremities; a rare variant is known as orofacial synovial sarcoma. In the case under report, a synovial sarcoma of the larynx in a 19-year old man is described. 11 months after surgical removal of the tumour neither recurrence nor lymph node metastasis had occurred. The literature on this rare tumour is briefly reviewed.

Adult↗
PubMed1984

Experimental studies on the pathogenesis of ochronotic arthropathy. The effects of homogentisic acid on adult and fetal articular chondrocyte morphology, proliferative capacity and synthesis of proteoglycans in vitro.

Lapine adult and fetal articular chondrocytes in monolayer culture were employed as an experimental model for studying the effects of homogentisic acid on chondrocyte morphology, proliferation and synthesis of proteoglycans. Concentrations of homogentisic acid in the range from 0.1 to 100 micrograms/ml were investigated and a cytotoxic effect was detected with concentrations of 5 micrograms/ml and above. Thus, with adult articular chondrocytes this effect was seen between 36 and 48 h of subculture with 5 micrograms/ml or more of homogentisic acid present from the beginning of subculture. In fetal articular chondrocyte cultures a concentration of 1 microgram/ml elicited a statistically significant reduction (13%) in cell proliferation without altering sulphated macromolecular synthesis. Experiments with 3H-thymidine autoradiography to measure the pulse labeling index (LI) in fetal chondrocytes in vitro showed that the 5 micrograms/ml concentration of homogentisic acid present for 21 h from the beginning of subculture gave a LI of 2%, compared with 25% for controls. Thus, homogentisic acid can reduce chondrocyte proliferative capacity before morphological alterations can be detected by light microscopy. No significant alterations in the synthesis of proteoglycans were detected at concentrations below the cytotoxic level. The homogentisic acid-induced cytotoxicity and reduction of proliferation in chondrocytes represents a possible pathway by which cartilage is damaged in ochronotic arthropathy.

Animals↗